PhD position in Developmental Biology
Sort on published: 2017-12-13
Uppsala University is a comprehensive research-intensive university with a strong international standing. Our mission is to pursue top-quality research and education and to interact constructively with society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has 42,000 students, 7,000 employees and a turnover of SEK 6.7 billion.
The Department of Organismal Biology teaches and explores the evolution, development and function on the organismal level. For more information see www.iob.uu.se.
Duties/Project description: The current concept about the mechanism of sexual differentiation of the brain during development includes not only the action of gonadal hormones but also the function of genes encoded by the sex chromosomes. In recent years, attention to Y functions in the brain during development has increased due to its proposed involvement in autism and non-syndromic speech delay. Using microarray analysis, we have shown that several Y encoded genes are expressed in the brain during human development.
To follow up, we now plan to investigate whether one or more genes encoded on the Y chromosome are involved in the determination of sex differences in the brain of mammals during early development. Specifically, the cellular expression of Y chromosome genes early during CNS development, before the primordial sex organs start to produce sex hormones, will be studied. This will be followed by an analysis of the involvement of these genes in critical neurodevelopmental processes as proliferation, cytodifferentiation, motility and regulation of cytoskeleton dynamics of human embryonic stem cells.
The PhD student is also expected to teach in the laboratory parts of the course entitled “Genes, Brain and Behaviour” about 10% of the time.
Requirements: A master degree (or equivalent) in cell and molecular biology, biomedicine or related area is required. We seek a candidate who is ambitious, motivated and with a strong interest in behavioural and neurodevelopmental genetics. Previous experience with neural stem cell cultivation and differentiation, qPCR, immunofluorescence and in situ hybridization are a strong advantage. The ideal candidate should be familiar with microscopy techniques (including confocal microscopy) and should be experienced with image analysis software as Imaris and ImageJ/Fiji macro programming. A good understanding of bioinformatics tools and deep knowledge in human genetics, neurobiology and development are also a merit. Candidates must be fluent in English.
In filling this position, the university aims to recruit the person who, in the combined evaluation of competence, skills and documented qualifications, is judged most suitable to carry out and develop the work-in-hand and to contribute to a positive development of the department.
The PhD-student position is a 4-year appointment, and the candidate will primarily devote the time to his/her own research studies. Other departmental work, such as teaching or administration can be part of the position (maximum 20 %). Salary placement is in accordance with local guidelines at Uppsala University. The applicant must be eligible for PhD studies at Uppsala University. Information about research education can be found at the web site of the Faculty of Science and Technology, http://www.teknat.uu.se/Doktorand/.
Application: Applications should include a brief description of research interests and relevant experience, a CV, copies of diplomas and certificates, thesis as well as other relevant documents that the applicant wishes to refer to.
Rules governing Ph.D. candidates are set out in the Higher Education Ordinance Chapter 5, §§ 1-7 and in Uppsala university's rules and guidelines http://regler.uu.se/search/?hits=30&languageId=1&search-language_en=English
Uppsala University strives to be an inclusive workplace that promotes equal opportunities and attracts qualified candidates who can contribute to the University’s excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.
Salary: According to local agreement for PhD students and teaching assistants.
Starting date: 01-03-2018, temporary position ending 28-02-2022.
Type of position: Full time position.
For further information about the position please contact
Professor Elena Jazin, e-mail firstname.lastname@example.org or Christiane Peuckert, e-mail email@example.com.
Please submit your application by 15 January 2018, UFV-PA 2017/4751.
Are you considering moving to Sweden to work at Uppsala University? If so, you will find a lot of information about working and living in Sweden at www.uu.se/joinus. You are also welcome to contact International Faculty and Staff Services at firstname.lastname@example.org.
We decline offers of recruitment and advertising help. We only accept the application the way described in the advertisement.
Placement: Department of Organismal Biology
Type of employment: Full time , Temporary position longer than 6 months
Pay: Fixed salary
Number of positions: 1
Working hours: 100 %
County: Uppsala län
Ellena Papaioannou, Seko
Per Sundman, Saco-rådet 018-471 1485
Suzanne Borén Andersson, TCO/ST 018-471 6251
Number of reference: UFV-PA 2017/4751
Last application date: 2018-01-15