Oscar Verho
Senior Lecturer/Associate Professor at Department of Medicinal Chemistry; Drug Design and Discovery
- E-mail:
- oscar.verho@ilk.uu.se
- Visiting address:
- Biomedicinskt Centrum BMC, Husargatan 3
- Postal address:
- Box 574
751 23 UPPSALA
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Short presentation
Oscar Verho obtained his PhD in 2014 from the group of Prof. Jan-Erling Bäckvall, and became Assocatie Professor and Senior Lecturer at the Department of Medicinal Chemistry in 2022. His research focuses on the design of new synthetic methodologies that can facilitate the synthesis of bioactive molecules and aid research in chemical biology and drug discovery. This involves research in both novel electrocatalyzed C-H functionalization metholodogies as well as DNA-encoded libraries.
Keywords
- c-h functionalization
- dna-encoded libraries
- drug discovery
- electrochemistry
- organic synthesis
Research
This text is not available in English, therefore the Swedish version is shown.
Currently, my group focuses on the design of new synthetic methodologies that can be used for the synthesis of biologically active compounds and small molecule libraries. Here, much of our recent research has been centered on 8-aminoquinoline directed C-H functionalization, as it constitutes a very powerful strategy for rapidly building up molecular complexity. My group is also fascinated by new techniques that can enable expedient synthesis and screening of compound libraries for drug discovery applications. Here, we are currently collaborating with the SciLifeLab in the design of different DNA encoded compound libraries.
Publications
Recent publications
- Bifunctional and regenerable molecular electrode for water electrolysis at neutral pH (2023)
- Cobalt Electrocatalyst on Fluorine Doped Carbon Cloth - a Robust and Partially Regenerable Anode for Water Oxidation (2022)
- Electrochemical Palladium-Catalyzed Oxidative Carbonylation-Cyclization of Enallenols (2022)
- The Impact of Ligand Carboxylates on Electrocatalyzed Water Oxidation (2021)
- A Study of an 8-Aminoquinoline-Directed C(sp(2))-H Arylation Reaction on the Route to Chiral Cyclobutane Keto Acids from Myrtenal (2021)
All publications
Articles
- Bifunctional and regenerable molecular electrode for water electrolysis at neutral pH (2023)
- Cobalt Electrocatalyst on Fluorine Doped Carbon Cloth - a Robust and Partially Regenerable Anode for Water Oxidation (2022)
- Electrochemical Palladium-Catalyzed Oxidative Carbonylation-Cyclization of Enallenols (2022)
- The Impact of Ligand Carboxylates on Electrocatalyzed Water Oxidation (2021)
- A Study of an 8-Aminoquinoline-Directed C(sp(2))-H Arylation Reaction on the Route to Chiral Cyclobutane Keto Acids from Myrtenal (2021)
- Investigation of the Deactivation and Reactivation Mechanism of a Heterogeneous Palladium(II) Catalyst in the Cycloisomerization of Acetylenic Acids by In Situ XAS (2021)
- Identification of unique and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries
Chapters
