Jakob Haglöf
Lecturer at Department of Medicinal Chemistry; Analytical Pharmaceutical Chemistry
- Telephone:
- +46 18 471 43 41
- E-mail:
- jakob.haglof@ilk.uu.se
- Visiting address:
- Uppsala biomedicinska centrum BMC, Husarg. 3
- Postal address:
- Box 574
751 23 UPPSALA
Educational developer (leave of absence) at University Administration; Division for Quality Enhancement; Academic Teaching and Learning
- Telephone:
- +46 18 471 43 41
- Visiting address:
- Dag Hammarskjöldsväg 7
75237 Uppsala - Postal address:
- Box 256
75105 Uppsala - Leave of absence:
- 2024-06-26 - 2025-07-01
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Short presentation
With a background as engineer in Biotechnology and a PhD in Pharmacy I work as alecturer and researcher in analytical pharmaceutical chemistry. As lecturer I teach students within the pharmasist, engineering and dispensing pharmasist programmes in pharmaceutical analysis. My research is aimed at developing analytical methods for metabolomics studies, with a particular focus on generating high data quality within these multidisciplinary studies.
Keywords
- analytical chemistry
- bioanalysis
- chemometrics
- chromatography
- experimental design
- mass spectrometry
- metabolomics
- multivariate data analysis
Biography
2004: MSc in Biotechnology, Chalmers University of Technology
2010: PhD in Pharmacy, Uppsala universitet
Publications
Recent publications
- DNA integrity under alkaline conditions (2023)
- Oceanographic setting influences the prokaryotic community and metabolome in deep-sea sponges (2022)
- A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma (2021)
- Adduct formation in electrospray ionisation-mass spectrometry with hydrophilic interaction liquid chromatography is strongly affected by the inorganic ion concentration of the samples (2019)
- Exploring Radiation Response in Two Head and Neck Squamous Carcinoma Cell Lines Through Metabolic Profiling (2019)
All publications
Articles
- DNA integrity under alkaline conditions (2023)
- Oceanographic setting influences the prokaryotic community and metabolome in deep-sea sponges (2022)
- A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma (2021)
- Adduct formation in electrospray ionisation-mass spectrometry with hydrophilic interaction liquid chromatography is strongly affected by the inorganic ion concentration of the samples (2019)
- Exploring Radiation Response in Two Head and Neck Squamous Carcinoma Cell Lines Through Metabolic Profiling (2019)
- An LCMS-based untargeted metabolomics protocol for cochlear perilymph (2019)
- Method selectivity evaluation using the co-feature ratio in LC/MS metabolomics (2018)
- The co-feature ratio, a novel method for the measurement of chromatographic and signal selectivity in LC-MS-based metabolomics. (2017)
- β-N-Methylamino-L-alanine (BMAA) perturbs alanine, aspartate and glutamate metabolism pathways in human neuroblastoma cells as determined by metabolic profiling (2017)
- Different functions of AKT1 and AKT2 in molecular pathways, cell migration and metabolism in colon cancer cells (2017)
- TAp73 is a marker of glutamine addiction in medulloblastoma (2017)
- Cisplatin-induced metabolome changes in serum (2017)
- LC-MS based global metabolite profiling (2016)
- Matrix effects in nilotinib formulations with pH-responsive polymer produced by carbon dioxide-mediated precipitation (2015)
- NMR-based metabolic profiling in healthy individuals overfed different types of fat (2015)
- Metabolic profiling of epithelial ovarian cancer cell lines (2015)
- NMR spectroscopy based metabolic profiling of drug induced changes in vitro can discriminate between pharmacological classes (2014)
- The cyanobacterial amino acid beta-N-methylamino-L-alanine perturbs the intermediary metabolism in neonatal rats (2013)
- Separation of amino alcohols using divalent dipeptides as counter ions in aqueous CE (2010)
- Effect of alkali metal hydroxides on the enantioseparation of amines using di-O-isopropylidene-keto-L-gulonic acid as the selector in NACE (2006)
- Multivariate data analysis of a chiral separation system using N-derivatized dipeptides as chiral counter-ions on porous graphitic carbon stationary phase
- Enantiomeric separation of amines using divalent dipeptides as chiral counter-ions in non-aqueous CE
- Optimization of In Vitro Microsome Incubations for Improved Drug Metabolite Yield Utilizing Experimental Design
Books
Conferences
- Evaluation of harvesting protocols for metabolic profiling of epithelial ovarian cancer cells (2014)
- Ototoxicity of Cisplatin Correlates with Changes in Blood Antioxidant Status (2014)
- Multivariate analysis of enantiomeric separation of amino alcohols using N-derivatized dipeptides as chiral selectors in HPLC (2010)
- Enantiomeric separation of amines using divalent N-derivatized dipeptides as chiral selectors in non-aqueous capillary electrophoresis (2008)
- Capillary electrophoretic studies of ion pairing in aqueous solution using N-derivatized dipeptides (2008)
