Olof Eriksson
Professor at Department of Medicinal Chemistry; Translational PET Imaging
- Telephone:
- +46 18 471 53 05
- E-mail:
- olof.eriksson@ilk.uu.se
- Visiting address:
- Dag Hammarskjöldsv 14C, 3tr
- Postal address:
- Dag Hammarskjöldsv 14C, 3tr
751 83 Uppsala
- ORCID:
- 0000-0002-2515-8790
More information is available to staff who log in.
Short presentation
My lab at Science For Life Laboratory and Uppsala University is applying in vivo molecular imaging techniques, e.g. Positron Emission Tomography (PET), for advancement of our understanding and treatment of different pathologies, in particular metabolic disease.
For more information, please visit my lab's websites at Uppsala University or SciLifeLab.
Keywords
- beta cell imaging
- biomedical image analysis
- diabetes
- immunotherapy
- inflammation
- molecular imaging
- neuroendocrine cancer
- pharmaceuticals
- positron emission tomography
- translational research
Publications
Recent publications
- Introduction of a fatty acid chain modification to prolong circulatory half-life of a radioligand towards glucose-dependent insulinotropic polypeptide receptor (2024)
- In Vivo Visualization and Quantification of Neutrophil Elastase in Lungs of COVID-19 Patients (2023)
- [18F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44 (2023)
- Preclinical evaluation of Affibody molecule for PET imaging of human pancreatic islets derived from stem cells. (2023)
- Radiotracers for Imaging of Fibrosis (2023)
All publications
Articles
- Introduction of a fatty acid chain modification to prolong circulatory half-life of a radioligand towards glucose-dependent insulinotropic polypeptide receptor (2024)
- In Vivo Visualization and Quantification of Neutrophil Elastase in Lungs of COVID-19 Patients (2023)
- [18F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44 (2023)
- Preclinical evaluation of Affibody molecule for PET imaging of human pancreatic islets derived from stem cells. (2023)
- Radiotracers for Imaging of Fibrosis (2023)
- Monitoring beta-Cell Survival After Intrahepatic Islet Transplantation Using Dynamic Exendin PET Imaging (2023)
- PET imaging of neutrophil elastase with 11C-GW457427 in Acute Respiratory Distress Syndrome in pigs (2023)
- Imaging of the Glucose-Dependent Insulinotropic Polypeptide Receptor Using a Novel Radiolabeled Peptide Rationally Designed Based on Endogenous GIP and Synthetic Exendin-4 Sequences (2023)
- Imaging of fibrogenesis in the liver by [18F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β (2023)
- Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist (2022)
- Glucagonlike Peptide-1 Receptor Imaging in Individuals with Type 2 Diabetes (2022)
- PET-CT imaging of pulmonary inflammation using [Ga-68]Ga-DOTA-TATE (2022)
- Heparin-Derived Theranostic Nanoprobes Overcome the Blood-Brain Barrier and Target Glioma in Murine Model (2022)
- The Current State of Beta-Cell-Mass PET Imaging for Diabetes Research and Therapies (2021)
- PET Imaging of GPR44 by Antagonist [C-11]MK-7246 in Pigs (2021)
- News ways of understanding the complex biology of diabetes using PET (2021)
- Drug Occupancy Assessment at the Glucose-Dependent Insulinotropic Polypeptide Receptor by Positron Emission Tomography (2021)
- Imaging of the Glucagon Receptor in Subjects with Type 2 Diabetes (2021)
- Longitudinal Assessment of 11C-5-Hydroxytryptophan Uptake in Pancreas After Debut of Type 1 Diabetes (2021)
- Exploring the GLP-1-GLP-1R axis in porcine pancreas and gastrointestinal tract in vivo by ex vivo autoradiography (2021)
- Discovery, optimization and biodistribution of an Affibody molecule for imaging of CD69 (2021)
- Potential of [C-11]UCB-J as a PET tracer for islets of Langerhans (2021)
- Radiolabelling and positron emission tomography imaging of a high-affinity peptide binder to collagen type 1 (2021)
- Improved Radiolytic Stability of a 68Ga-labelled Collagelin Analogue for the Imaging of Fibrosis (2021)
- Recent Progress in the Molecular Imaging of Nonalcoholic Fatty Liver Disease (2021)
- Receptor occupancy of dual glucagon-like peptide 1/glucagon receptor agonist SAR425899 in individuals with type 2 diabetes (2020)
- [11C]5-Hydroxy-tryptophan model for quantitative assessment of in vivo serotonin biosynthesis, retention and degradation in the endocrine pancreas (2020)
- Advances in GLP-1 receptor targeting radiolabeled agent development and prospective of theranostics (2020)
- Heterogeneity of Metabolic Defects in Type 2 Diabetes and Its Relation to Reactive Oxygen Species and Alterations in Beta-Cell Mass (2019)
- Synthesis and preclinical evaluation of the CRTH2 antagonist [11C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass (2019)
- GPR44 as a Target for Imaging Pancreatic Beta-Cell Mass (2019)
- Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes. (2019)
- Assessment of glucagon receptor occupancy by Positron Emission Tomography in non-human primates (2019)
- Pancreatic perfusion and its response to glucose as measured by simultaneous PET/MRI (2019)
- Tools for Bioimaging Pancreatic beta Cells in Diabetes (2019)
- Overeating saturated fat promotes fatty liver and ceramides compared to polyunsaturated fat (2019)
- First-in-class positron emission tomography tracer for the glucagon receptor (2019)
- Transplantation of macroencapsulated human islets within the bioartificial pancreas βAir to patients with type 1 diabetes mellitus (2018)
- In Vivo Visualization of beta-Cells by Targeting of GPR44 (2018)
- Pancreatic imaging using an antibody fragment targeting the zinc transporter type 8 (2018)
- Detection and quantification of beta cells by PET imaging (2018)
- The development of a GPR44 targeting radioligand [11C]AZ12204657 for in vivo assessment of beta cell mass. (2018)
- Cannabinoid Type 1 Receptors Are Upregulated During Acute Activation of Brown Adipose Tissue (2018)
- Increased Expression of GLP-1R in Proliferating Islets of Men1 Mice is Detectable by [Ga-68]Ga-DO3A-VS-Cys(40)- Exendin-4/PET (2018)
- [(11)C]5-Hydroxy-Tryptophan PET for Assessment of Islet Mass During Progression of Type 2 Diabetes (2017)
- Species differences in pancreatic binding of DO3A-VS-Cys40-Exendin4 (2017)
- Combined PET and microdialysis for in vivo estimation of drug blood-brain barrier transport and brain unbound concentrations (2017)
- Toward molecular imaging of the free fatty acid receptor 1 (2017)
- Metformin treatment significantly enhances intestinal glucose uptake in patients with type 2 diabetes (2017)
- Radiochemistry and Preclinical Evaluation of Two Novel Peptide Analogues Targeting Glucagon Receptor for AntiDiabetic Drug Development (2017)
- Fully automated GMP production of [Ga-68]Ga-DO3A-VS-Cys(40)-Exendin-4 for clinical use (2017)
- Pancreatic perfusion and subsequent response to glucose in healthy individuals and patients with type 1 diabetes (2016)
- In vivo imaging of beta cells with radiotracers (2016)
- Positron Emission Tomography to assess the outcome of intraportal islet transplantation (2016)
- Quantification of Beta-Cell Mass in Intramuscular Islet Grafts using Radiolabeled Exendin-4 (2016)
- Evaluation of a novel type of imaging probe based on a recombinant bivalent mini-antibody construct for detection of CD44v6-expressing squamous cell carcinoma (2016)
- GPR44 is a pancreatic protein restricted to the human beta cell (2016)
- Cannabinoid CB1 receptors in human brown adipose tissue during cold exposure (2016)
- Cardiovascular side-effects and insulin secretion after intravenous administration of radiolabeled Exendin-4 in pigs (2016)
- Molecular imaging of EGFR and CD44v6 for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma model. (2016)
- Feasibility of Multiple Examinations Using Ga-68-Labelled Collagelin Analogues (2016)
- Ga-68/PET imaging and quantification of fibrosis using peptide-based tracers (2016)
- [C-11] Carfentanil Binds Preferentially to mu-Opioid Receptor Subtype 1 Compared to Subtype 2 (2015)
- Synthesis and biological evaluation of [C-11]AZ12504948; a novel tracer for imaging of glucokinase in pancreas and liver (2015)
- Systematic screening of imaging biomarkers for the Islets of Langerhans, among clinically available positron emission tomography tracers (2015)
- Molecular imaging of EGFR and EGFRvIII for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma model (2015)
- Rat organ distribution of [Lu-177]-DO3A-VS-Cys(40)-Exendin-4 for the estimation of human dosimetry (2015)
- Extrapolated dosimetry of two novel Ga-68-labelled imaging agents for fibrosis (2015)
- Dosimetry of [Ga-68]Ga-DO3A-VS-Cys(40)-Exendin-4 in rodents, pigs, non-human primates and human (2015)
- Dosimetry of 68Ga and 177Lu labeled Exendin4-impact on feasibility of repeated PET imaging and radiotherapy (2014)
- 5-Hydroxy-L-[beta-C-11]-tryptophan Deuterium Isotopologue Shows Increased Retention In Neuro-endocrine Cells Due To Secondary Kinetic Isotope Effect (2014)
- Strategy to develop a MAO-A-resistant 5-hydroxy-L-[beta-C-11]tryptophan isotopologue based on deuterium kinetic isotope effects (2014)
- The Positron Emission Tomography ligand [11C]5-Hydroxy-Tryptophan can be used as a surrogate marker for the human endocrine pancreas (2014)
- On the use of [F-18]DOPA as an imaging biomarker for transplanted islet mass (2014)
- Quantitative Imaging of Serotonergic Biosynthesis and Degradation in the Endocrine Pancreas (2014)
- Detection of Metastatic Insulinoma by Positron Emission Tomography with [(68)Ga]Exendin-4 - (2014)
- Positron emission tomography imaging of the glucagon-like peptide-1 receptor in healthy and streptozotocin-induced diabetic pigs (2014)
- Positron Emission Tomography imaging of the glucagon like peptide-1 receptor in healthy and streptozotocin-induced diabetic pigs (2014)
- PET imaging of the GLP-1 receptor in healthy and streptozotocin-induced diabetic pigs (2014)
- Pre-clinical evaluation of [(68)Ga]Ga-DO3A-VS-Cys(40)-Exendin-4 for imaging of insulinoma (2014)
- Dosimetry of [68Ga]Ga-DO3A-VS-Cys40-Exendin-4 in rat, non-human primate and human (2014)
- Gallium-68-labeled affibody molecule for PET imaging of PDGFR beta expression in vivo (2014)
- Gallium-68-Labeled Affibody Molecule for PET Imaging of PDGFRβ Expression in Vivo (2014)
- Development of a I-124-labeled version of the anti-PSMA monoclonal antibody capromab for immunoPET staging of prostate cancer (2014)
- Imaging of platelet-derived growth factor receptor β expression in glioblastoma xenografts using affibody molecule 111In-DOTA-Z09591 (2014)
- Synthesis and preclinical evaluation of Ga-68-labeled collagelin analogs for imaging and quantification of fibrosis (2014)
- 5-Fluoro-[beta-C-11]-L-tryptophan is a functional analogue of 5-hydroxy-[beta-C-11]-L-tryptophan in vitro but not in vivo (2013)
- Imaging the in vivo fate of human T cells following transplantation in immunoincompetent mice - Implications for clinical cell therapy trials (2013)
- beta-Cell Mass Imaging with DTBZ Positron Emission Tomography (2013)
- 5-Fluoro-[beta-C-11]-L-tryptophan is a functional analogue of 5-hydroxy-[beta-C-11]-L-tryptophan in vitro but not in vivo (2013)
- Functional Imaging of the Pancreatic Graft by Positron Emission Tomography (2013)
- In Vivo Imaging of the Glucagonlike Peptide 1 Receptor in the Pancreas with Ga-68-Labeled DO3A-Exendin-4 (2013)
- In vivo imaging of PDGFR beta expression using In-111-DOTA-Z09591 Affibody molecule (2013)
- Imaging of PDGFRbeta expression in vivo using Affibody molecule In-111-DOTA-Z09591 (2013)
- Synthesis and preclinical evaluation of Ga-68-labelled collagelin analogues for imaging and quantification of fibrosis (2013)
- Ga-68-labelling of Exendin-4, preclinical evaluation of the resultant tracer for the imaging and quantification of insulinomas, and case patient examination (2013)
- Imaging the islet graft by positron emission tomography (2012)
- Preclinical evaluation of a 68Ga-labeled biotin analogue for applications in islet transplantation (2012)
- Pancreatic uptake of [68Ga]DO3A-Exendin4 is mediated by the GLP-1 receptor (2012)
- Assessment of receptor occupancy-over-time of two dopamine transporter inhibitors by [C-11]CIT and target controlled infusion (2011)
- Distribution of adoptively transferred porcine T-lymphoblasts tracked by (18)F-2-fluoro-2-deoxy-D-glucose and position emission tomography (2011)
- Striated Muscle as Implantation Site for Transplanted Pancreatic Islets (2011)
- Decreased defluorination using the novel beta-cell imaging agent [18F]FE-DTBZ-d4 in pigs examined by PET (2011)
- In vivo and in vitro characterization of [18F]-FE-(+)-DTBZ as a tracer for beta-cell mass (2010)
- Positron emission tomography in clinical islet transplantation (2009)
- Synthesis and in vitro evaluation of 18F-β-carboline alkaloids as PET ligands (2008)
- Positron emission tomography and target-controlled infusion for precise modulation of brain drug concentration (2008)
- A computerized Infusion Pump for control of tissue tracer concentration during Positron Emission Tomography in vivo Pharmacokinetic/Pharmacodynamic measurements (2008)
- Visualization of early engraftment in clinical islet transplantation by positron-emission tomography (2007)
- Positron emission tomography (2007)
- Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET (2006)
- Lead compound identification from first-in-class high affinity Affibody molecules binders towards DGCR2
- Preclinical evaluation of Affibody molecule 18F-TZ-ZAM106 for PET imaging of DGCR2
- Non-invasive imaging methodologies for assessment of Peptide Receptor Radiotherapy damage to bone marrow and kidney
- Positron Emission Tomography imaging of CD69 in a murine model of rheumatoid arthritis
Books
Conferences
