Entry requirements

120 credits inclusive Genomics – experimental methods and Methods in bioinformatics, or equivalent.

Learning outcomes

The course treats genome organisation, variation, evolution and function in different groups of organisms.

After the course, the student shall be able to

• Describe the genome architecture in selected organism groups
• Explain how different reproductive systems affect genome
• size and composition
• Sketchan explanatory model for the difference (in architecture and gene content) between genomes
• Explainhow genetic and transcriptional networks are regulated (on different levels)
• Explain how complex traits are controlled genetically and how genes involvedare identified
• Discuss the practical consequences of the genome's biologyon bioinformatics applications

Content

Genome organisation, variation and expression

Genome content and architecture in different organismgroups, variation in the genome and its significance for the organism, mechanisms controlling gene expression.

Genome evolution

Forces and mechanisms controlling the genome's architecture; gene and genome duplications, organelles and plasmids, proliferation of repetitive and selfish elements, horizontal gene transfer. Comparative genomics, sexual reproduction and other recombination processes, sex and sex determination, genomic aspects on speciation.

Genome function

Genetic and transcriptional networks, their regulation, epigenetics, genetics underlying complex traits, identification of genes affecting important properties (QTL analysis, genome-wide association mapping). Interactions between metabolic networks in natural settings; symbiosis and metagenomics.

Instruction

Instruction will be given as lectures, seminars and computer assignments.

Assessment

The theory part of the course is examined by a written theoretical examination and participation in seminars, equivalent to a total of 3 credits. Active participation in at least 80% of the seminars is required to pass. To pass the practical part, it is required that all computer exercises equivalent to 2 credits has been presented in writing and is passed.