Entry requirements

120 credits. Alt 1) 60 credits biology and 30 credits chemistry alt 2) chemistry 60 credits including Biochemistry 15 credits and biology 30 credits including molecular genetics 15 credits.

Learning outcomes

The course shall give the student increased knowledge on the biological functions of the RNA molecule and how cell processes are regulated by RNA, RNA-binding proteins, and the ribonucleoprotein complex. After passing the course, the student shall be able to

<ul>

<li>explain the biology, chemistry, structure, and function of the RNA molecule</li>

<li>explain how the RNA molecule participates in the control of living cells</li>

<li>explain how the function of the RNA molecule is regulated by proteins and small ligands</li>

<li>evaluate and explain practical applications of the RNA molecule within medicine and biotechnology</li>

<li>apply a scientific approach in the planning, execution, explanation, and interpretation of advanced experiments on current RNA problems within its biology, chemistry, structure, and function, and also to critically assess the results and generate testable hypotheses from these experiments</li>

<li>critically evaluate scientific literature in the area</li>

<li>present and defend summaries of published literature in the area.</li>

</ul>

Content

The student achieves these goals by acquiring knowledge of:

<ul>

<li>The biology, chemistry, structure and function of the RNA molecule in prokaryotic and eukaryotic systems including their viruses. </li>

<li>Use of RNA-based methodology in medical and biotechnical applications.</li>

<li>The role and function of RNA in the regulation of gene expression. </li>

<li>Interaction between RNA molecules. </li>

<li>Interaction between RNA and proteins. </li>

<li>Interaction between RNA and small ligands. </li>

<li>The role of RNA in an evolutionary perspective. </li>

<li>The characteristics of metal ions and their importance/ function for the function of RNA. </li>

<li>Biochemical, genetic and physiological methods in the role and characteristics of RNA. </li>

<li>Practical experiments illustrating the functional role of RNA. </li>

</ul>

Instruction

Teaching is given in the form of lectures, web-based assignments, seminars, a literature symposium, and laboratory exercises.

Assessment

Modules: Laboratory exercises (2 credits); Seminars and symposium (3 credits); Theory (10 credits). The laboratory exercises must be approved and presented according to the guidelines. Active participation and approved presentations are required for the seminars and symposium. The theory module has a written examination

Other directives

The course can not at the same time be included with 1BG330 Microbial and chemical genetics.