Entry requirements

Basic Chemistry, 10 credits and Organic Chemistry, 5 credits or equivalent.

Learning outcomes

On completion of the course, the student should be able to:

• use rules for description of the structure and stereochemistry of bioorganic compounds
• relate the chemical structure of biomolecules to properties such as solubility, binding ability (hydrogen bond ability, lipophilicity, hydrophilicity), chirality
• correlate the chemical structure of biomolecules to reactivity
• discuss similarities and differences between transformations of biomolecules in living systems (aquatic environment) and in vitro, e.g. industrial synthesis
• describe how some course concepts are applied within the biomolecular - and pharmaceutical sciences
• give examples of how chemical properties and reactivity can influence environmental and economical decisions
• discuss appropriate chromatographic methods for determination of organic compounds
• plan and carry out laboratory work in a correct and safe manner and carry out simpler risk and security assessments

Content

Organic Chemistry of biologically relevant compound classes: Carbohydrates, lipids, amino acids and peptides, nucleic acids. Reaction mechanisms to build and degrade carbon compounds. Examples of catalytic reactions: Acid -base catalysis, enzymatic catalysis, metal catalysis (in biological systems). Organic-chemical reactions in water. Comparison between synthesis in biological systems and industrial synthesis. The fundamentals of chromatographic separation. Analysis of biomolecules, e g, peptides, nucleic acids by chemical and spectroscopic methods.

Instruction

Lectures, problem solving sessions and laboratory work. Laboratory work and related presentations are mandatory.

Assessment

Written examinations are organised at the end of the course and/or during the course and corresponds to 3 credits. The laboratory sessions correspond to 2 credits. To pass final grades it is required that all parts have been assessed passed. The final grade is the weighted grade of both theoretical and experimentel work.

If there are special reasons for doing so, an examiner may make an exception from the method of assessment indicated and allow a student to be assessed by another method. An example of special reasons might be a certificate regarding special pedagogical support from the disability coordinator of the university.

Other directives

The course can not be included in higher education qualification together with 1KB472 Introductory Organic Chemistry.