Entry requirements

For students in the Master of Science Programme in Pharmacy: At least 150 credits within the programme including Organic Chemistry with a specialisation in Drugs, Pharmaceutical Chemistry and Drug Synthesis.

For students taking the course as a single-subject course: At least 150 credits of which at least 90 credits including at least 15 credits in second-cycle courses in Pharmaceutical Chemistry, or the equivalent.

Proficiency in Swedish and English equivalent to that required for Swedish first-cycle programmes.

Admitted to the Master Programme in Drug Discovery and Development.

Learning outcomes

After completing the course, the student should be able to:

• propose and critically evaluate synthetic methods for the most important organic-chemical transformations and explain their mechanisms.
• predict and understand how structural properties influence reaction mechanisms and reactivity of organic molecules
• describe and apply methods for investigating reaction mechanisms.
• discuss the three-dimensional structure of advanced organic molecules and explain their stereochemical relations
• describe and apply basic organometallic chemistry of importance for organic synthesis
• perform advanced retrosynthetic analyzes and plan complex multistep syntheses
• plan and evaluate syntheses of advanced drug substances
• search, analyze and orally present and discuss advanced scientific literature in organic and drug synthesis

Content

The course deals with chemical bonding, molecular orbital theory, stereochemical, structural and stereoelectronic principles, thermodynamic, kinetic, stereochemical and isotope-based studies, description of a large number of reaction mechanisms including nucleophilic substitutions, electrophilic substitutions, polar additions and eliminations, oxidations and reductions, radical-mediated, metal-catalyzed and metal-mediated reactions and aromaticity. The subject of drug synthesis deals with synthetic and retrosynthetic methods, catalysis for organic synthesis and synthesis planning with a focus on drug chemical applications.

Emphasis is placed on the student's ability to independently obtain, process and communicate scientific information about organic and drug synthesis.

Instruction

The course is given in the form of self-study and seminars. The course may be given in English.

Compulsory elements: Seminars

Assessment

Written exam takes place at the end of the course. For a passed course, a passed exam (10 credits), active participation in compulsory parts (3.5 credits) and a scientific presentation in English (1.5 credits) are required. Re-taking failed compulsory parts of the course can occur, at the earliest, at next course and then only if the course is not full.

If there are special reasons for doing so, an examiner may make an exception from the method of assessment indicated and allow a student to be assessed by another method. An example of special reasons might be a certificate regarding special pedagogical support from the University's disability coordinator.

If there are special reasons, the examiner may make exceptions from the specified examination method and allow a student to be examined in another way. Special reasons can e.g. be informed of special pedagogical support from the university's coordinator.

Other directives

The course cannot be included in the degree together with Advanced Organic Chemistry with a focus on drug synthesis or molecular modeling 3FK179 due to partially overlapping content.

Replaces and corresponds to Advanced Organic Chemistry and Drug Synthesis 3FK180.