Entry requirements

45 credits in chemistry/chemical engineering/pharmaceutics/biotechnology

Learning outcomes

After the completion of the course, participants will be able to:

• Give examples of filter configurations used in bioprocessing,
• Explain most common routes of membrane manufacturing for biopharmaceutical applications,
• Discuss the fundamental mechanisms of particle retention and filter fouling,
• Choose an appropriate filter characterization technique for a given application.

Content

The course covers both theoretical and practical basis of filter design and characterization. The following topics will be covered.

Materials for filters suitable for bioprocessing; common methods of filter preparation; filter design and filtration modes; mechanisms of particle retention; most penetrating particle size (MPPS); key filter and operation parameters; absolute and nominal filter ratings; mathematical models for filter fouling; physical-chemical, mechanical and microbiological characterisation of filters, including but not limited to, e.g., displacement (intrusion) techniques, thermo- and cryoporometry, tracer retention techniques; non-destructive and destructive integrity testing.

Instruction

Lectures, seminars, and laboratory praxis. 

Assessment

Mandatory active participation in laboratory praxis and seminars (1 credit). Oral exam (2 credits).