Filtration in Biopharmaceutical Industry I
Syllabus, Bachelor's level, 1TM029
- Code
- 1TM029
- Education cycle
- First cycle
- Main field(s) of study and in-depth level
- Technology G1F
- Grading system
- Fail (U), Pass (G)
- Finalised by
- The Faculty Board of Science and Technology, 29 February 2024
- Responsible department
- Department of Materials Science and Engineering
Entry requirements
45 credits in chemistry/chemical engineering/pharmaceutics/biotechnology
Learning outcomes
After the completion of the course, participants will be able to:
- Give examples of filter configurations used in bioprocessing,
- Explain most common routes of membrane manufacturing for biopharmaceutical applications,
- Discuss the fundamental mechanisms of particle retention and filter fouling,
- Choose an appropriate filter characterization technique for a given application.
Content
The course covers both theoretical and practical basis of filter design and characterization. The following topics will be covered.
Materials for filters suitable for bioprocessing; common methods of filter preparation; filter design and filtration modes; mechanisms of particle retention; most penetrating particle size (MPPS); key filter and operation parameters; absolute and nominal filter ratings; mathematical models for filter fouling; physical-chemical, mechanical and microbiological characterisation of filters, including but not limited to, e.g., displacement (intrusion) techniques, thermo- and cryoporometry, tracer retention techniques; non-destructive and destructive integrity testing.
Instruction
Lectures, seminars, and laboratory praxis.
Assessment
Mandatory active participation in laboratory praxis and seminars (1 credit). Oral exam (2 credits).
Reading list
No reading list found.