Filtration in Biopharmaceutical Industry I

3 credits

Syllabus, Bachelor's level, 1TM029

Code
1TM029
Education cycle
First cycle
Main field(s) of study and in-depth level
Technology G1F
Grading system
Fail (U), Pass (G)
Finalised by
The Faculty Board of Science and Technology, 29 February 2024
Responsible department
Department of Materials Science and Engineering

Entry requirements

45 credits in chemistry/chemical engineering/pharmaceutics/biotechnology

Learning outcomes

After the completion of the course, participants will be able to:

  • Give examples of filter configurations used in bioprocessing,
  • Explain most common routes of membrane manufacturing for biopharmaceutical applications,
  • Discuss the fundamental mechanisms of particle retention and filter fouling,
  • Choose an appropriate filter characterization technique for a given application.

Content

The course covers both theoretical and practical basis of filter design and characterization. The following topics will be covered.

Materials for filters suitable for bioprocessing; common methods of filter preparation; filter design and filtration modes; mechanisms of particle retention; most penetrating particle size (MPPS); key filter and operation parameters; absolute and nominal filter ratings; mathematical models for filter fouling; physical-chemical, mechanical and microbiological characterisation of filters, including but not limited to, e.g., displacement (intrusion) techniques, thermo- and cryoporometry, tracer retention techniques; non-destructive and destructive integrity testing.

Instruction

Lectures, seminars, and laboratory praxis. 

Assessment

Mandatory active participation in laboratory praxis and seminars (1 credit). Oral exam (2 credits). 

No reading list found.

FOLLOW UPPSALA UNIVERSITY ON

facebook
instagram
twitter
youtube
linkedin