Påverkan av genetik och livsstil för osteoporos och osteoporosfrakturer

Tidsperiod: 2012-01-01 till 2015-12-31

Projektledare: Karl Michaëlsson

Medarbetare: Alicja Wolk, Nancy Pedersen, Håkan Melhus

Finansiär: Vetenskapsrådet

Bidragstyp: Projektbidrag

Budget: 4 880 000 SEK

Osteoporotic fractures are common in Sweden. We don?t know why. The significance of lifestyle, comorbidity and genetic constitution on the risk of osteoporotic fractures is going to be examined in a cohort of 2300 men followed with six repeat examinations during 40 years and within the large Swedish twin registry. One modifiable but still uncertain risk factor for osteoporosis is the diet. Dietary habits of 65,000 women were examined 20 years ago. Two re-examinations have been done. The longitudinal dietary data will improve the precision of the nutrient and fracture risk calculations. In addition, we have established a subcohort of 5000 women within the larger cohort. These women have again been interviewed regarding dietary habits but also investigated by bone scans, gene and serum analyses. Reexaminations will yet again be done on average 10 years after the first bone scans to retrieve changes that can be linked to dietary habits. We are also going to compare genes, cardiovascular function and bone density in an attempt to discover common pathogenetic mechanisms for the linkage between cardiovascular diseases and osteoporosis. In three nested case-control studies we will use proteomics to discover novel proteins associated with osteoporosis. By interviews, we will try to identify fall circumstances that preceded hip fracture events. Finally, in a nation-wide cohort analysis we will analyze the relation between bisphosphonate use and risk of different fractures.