Jon-inducerade nanostrukturerade biokeramer
Tidsperiod: 2014-01-01 till 2017-12-31
Projektledare: Wei Xia
Budget: 3 860 000 SEK
The demand of a drug treatment at specific site increases sharply in musculoskeletal diseases and disorders. Bioceramic material is the natural candidate in this area because of their inherent properties. However, no ceramic drug carriers currently fully meet the requested profile. To fabrication of the hierarchical nanostructures which fit for the application is challengeable. In this project, we intend to develop a novel ion induced mineralization technology to synthesize nanostructure bioceramics as carrier materials. The main aim is to design and prepare new bioceramics with high drug loading capability and slow release to fulfill the high unmet need of drug treatments for the local bone reconstruction. The secondary aim is to figure out how inorganic ions stimulate the self-assembly of ceramic crystals, and to establish fundamental understanding of the mineralization of ceramic materials, which can be further used to synthesize new ceramics with hierarchical structures. The microstructure and crystallinity of materials will be evaluated experimentally by SEM, TEM, XPS, synchrotron X-ray scattering and neutron powder diffraction. DFT calculations on crystalline CaPs are used to investigate its structural modifications. Regular drugs will be loaded via the adsorption and co-precipitation ways. The loading of "ion drugs" will be doped by the co-mineralization and ion-exchange processes. The dose effect of loaded drugs will be tested in vitro with the collaboration.