Immuncellernas roll vid hälsa och sjukdom
Tidsperiod: 2015-01-01 till 2018-12-31
Projektledare: Mia Phillipson
Budget: 4 000 000 SEK
Immune cells (leukocytes) have essential roles in many situations in the body and are vital for survival. However, they are also driving detrimental inflammation, contributing to the majority of diseases. Thus, increased knowledge of the mechanisms regulating leukocyte recruitment and activation is central to limit this inflammatory response. I have previously established a new step in the leukocyte recruitment cascade, intravascular crawling, and identified a pro-angiogenic neutrophil subset essential for blood vessel growth. The overall aim of the research conducted in my laboratory is to uncover new roles of leukocytes and to find means to regulate their specific functions in settings spanning from organ development to tissue healing, angiogenesis and inflammation. By employing state of the art techniques for studies of leukocyte trafficking and interactions in vivo (e.g. high speed confocal microscopy), we are delineating how different leukocytes are recruited to sites of inflammation or hypoxia as well as their effector functions in tissue. I will also target the microenvironment to induce specific recruitment and leukocyte phenotype shifts. Translation of our findings into the clinic is facilitated by close collaboration within the Nordic Network for Clinical Islet Transplantation and Uppsala University Hospital. Increased understanding of leukocyte contribution to diverse situations would reveal novel strategies to prevent, control and treat diseases.