Samarbete för utveckling av robust och exakt bildanalys för kostnadseffektiv och pålitligt detektion av cancer vid gynekologisk hälsokontroll
Tidsperiod: 2015-01-01 till 2017-12-31
Projektledare: Ewert Bengtsson
Medarbetare: Ewert Bengtsson, Natasa Sladoje, Joakim Lindblad
Budget: 633 000 SEK
Cervical cancer is killing a quarter of a million women worldwide every year. Screening based on analysis of so called PAP-smears has proven very effective in reducing cancer mortality. Systematic screening is still not offered in most parts of the world due to cost and lack of cytotechnologists, leading to many unnecessary early deaths.This project aims at establishing a long lasting collaboration between research groups at Uppsala University and at University of Novi Sad, Serbia, with a primary goal to improve image analysis methods for cervical cancer diagnostics. By increasing reliability of automatic analysis, and allowing usage of less expensive microscopes and staining protocols, we will significantly contribute to the implementation of cost effective screening programs in developing countries.Advances in cytopathology have put focus on the analysis of very subtle changes in the chromatin structure of cell nuclei. Prof. Bengtsson´s group is among world leaders in this field. The objects of interest, chromatin particles in the cell nuclei, are close to the resolution limit of light microscopy and maximal usage of information in acquired images is paramount. Methods for robust and precise image analysis, developed by the group of Dr Sladoje, are most suitable for this task and initial tests have shown great potential. Adjustment of those methods to the analysis of chromatin distributions in cell nuclei is a challenging, but also very promising and rewarding task.