Screening för bukaortaaneurysm, en populationsbaserad longitudinell kohort studie av äldre män i Uppsala län

Tidsperiod: 2014-01-01 till 2017-12-31

Projektledare: Anders Wanhainen

Finansiär: Vetenskapsrådet

Bidragstyp: Projektbidrag

Budget: 4 940 000 SEK

Ruptured abdominal aortic aneurysm (AAA) causing an estimated 1.000 deaths annually in Sweden. To reduce the mortality screening risk groups has been proposed. The first population-based AAA screening program in Sweden started in Uppsala in 2006, inviting all 65-year old men. The program spread and in 2013 >90% of all Swedish 65 year old men were invited. We now intend to re-screen the cohort "men borne 1941-1945 in the county of Uppsala" at the age of 70 years and every five year thereafter. The overall aim is to study the long-term risk of aneurysm development and events in order to update strategies for AAA-screening in a contemporary Swedish setting. Questions asked are; Should we screen all men, or should we target high-risk individuals only (for examples smokers)? Should we screen 65-year old men once, or is there a need for re-screening later in life? Should individuals with sub-aneurysmal aortas (25-29 mm) be included in a surveillance program, and how should such a program be designed?In addition, a biobank with blood and tissue from individuals with AAA and controls is being created. The aim is to study pathophysiological mechanisms for aneurysm formation and progression of the disease.The project started in 2011, initially supported by The Swedish Heart and Lung Foundation and later by VR (Kunskapsluckor i sjukvården 2011-2014). We now seek additional financing from VRs ?Rambidrag inom klinisk behandlingsforskning? for 2015-2017.