Långtidsbehandling med opioider vid kroniska smärttillstånd: nytta och arbetsförmåga kontra beroende och missbruk

Tidsperiod: 2017-01-01 till 2019-12-31

Projektledare: Pernilla Åsenlöf

Medarbetare: Lisa Ekselius, Rolf Karlsten, Markus Heilig

Finansiär: Vetenskapsrådet

Bidragstyp: Projektbidrag

Budget: 2 100 000 SEK

This multidisciplinary project targets central gaps of knowledge regarding risks and benefits with chronic opioid treatment (> 3 months) in chronic non-cancer pain.The aim is two-folded:(1) To recruit a cohort and prospectively identify those with chronic painwho either benefit from chronic opioid treatment or is at risk fordeveloping opioid use disorders. (2) In a randomised controlled trial (RCT), evaluate the additive effects of a physical exercise intervention including behavioural skills training in comparison with a workplace intervention for patients with COT.Acohort of 1000 patients referred to a specialised Pain Centre will be recruited. At baseline,they will be classified with respect to current opioid use and severity of opioid use disorder. Groupswill then be characterised by a broad bio-psycho-social testbattery to identify predictors of opioid use disorders and benefits e.g. work ability, after 18 months.For the RCT, 84 patients with chronic pain and COT on sick-leave from ordinary employment will be recruited from the Pain Centre. Participants will be randomised to: (1) work-directed physical exerciseintervention including behavioural skills training and a 4-session workplace intervention. (2) A 4-session workplace intervention only.Primary outcome is return to work and self-reported workability. Outcomes will be measured at baseline and after 6, 12, and 24 months. Main studies will go on from January 2017 to December 2021.