Osteodiagnosis - En ny modalitet för övervakning av Osteogenesis i ben relaterade defekter

Tidsperiod: 2018-01-01 till 2021-12-31

Projektledare: Robin Augustine

Finansiär: Vetenskapsrådet

Bidragstyp: Projektbidrag

Budget: 3 200 000 SEK

Microwaves for medical diagnosis is a highly innovative technique. This project aims at making a significant step towardsits implementation by1. In vivo dielectric characterization of human bone and other tissues in the microwave frequency range of 1-10GHz.2. Designing and fabricating sensors and3. Measurements on a range of phantoms having realistic permittivity profile derived from 1.4. Pilot clinical study to understand the interaction mechanism of microwaves and human tissues.The feasibility of differentiating bone defects based on their dielectric profile, such as post craniotomy ossification atdifferent mineralization levels will be demonstrated in this project. In this work we will use clinical examples to study theinfluence on microwave signals by newly formed bone layers. Craniosynostosis patients who have undergone craniotomywill participate in the pilot clinical trial since they have larger defect sizes, faster bone regeneration and the defect issituated next to skin layer.Craniotomy is a surgical intervention adopted as part of craniosynostosis treatment. Defects(created by removal of bone flaps or opening of skull using spacers) of various size and shapes are made in the skull andthese defects gets healed gradually. Microwave sensors will be developed to analyze bone development in these skulldefect models. These sensors will be optimized for very low power (approval :Dnr 2016/086, Landstiget i Uppsala Län.