Utveckling av de novo bio-oorganiska system för oxidativ och reduktiv fotokatalys i välordnade proteinmiljöer.
Tidsperiod: 2018-01-01 till 2021-12-31
Projektledare: Starla Glover
Bidragstyp: Bidrag för anställning eller stipendier
Budget: 3 466 000 SEK
New photocatalysts developed for CO2 reduction, H2 evolution, and H2O oxidation will be based on pyridine, cobaloxime, and tetra-coordinate Co2+ molecular catalysts incorporated into protein scaffolds of well-defined three a-helical bundles (α3). α3X protein scaffolds will be reengineered to host the catalyst in the core and a photosensitizer on the exterior of the protein. This strategy enables catalysts to be water soluble and protected from unwanted chemistry. Protein purity and structural integrity will be verified by standard characterization methods. Protein film voltammetry will be used to determine thermodynamics of catalysis and measure α3X-catalyst activity. Continuous irradiation will be a second measure of catalytic activity and long-term stability. Transient spectroscopic methods will reveal kinetics associated with discrete redox events contributing to catalysis. To provide insight into how α3X scaffold dynamics are involved in catalysis time resolved NMR-based hydrogen/deuterium exchange methods will be used. Taken together, results from these studies will provide a rich understanding of each catalytic process and will ultimately provide important guiding principles for designing more effective catalyst systems that are driven by light. This research will present a significant step forward in biomimetic chemistry, catalysis and solar fuels research through detailed investigations of new these photocatalytic motifs.