Testning av de biologiska egenskaperna hos biokeramer i realtid och med högre tillförlitlighet med hjälp av biomaterial-på-chip

Tidsperiod: 2018-01-01 till 2021-12-31

Projektledare: Gemma Mestres, Gemma Mestres Beà

Finansiär: Vetenskapsrådet

Bidragstyp: Bidrag för anställning eller stipendier

Budget: 3 600 000 SEK

Bioceramics hold a great promise to promote bone regeneration leaving no traces behind. Before a newly designed bioceramic can be released to the market, its biological properties must be evaluated both in the lab using cells (in vitro) and in animal models (in vivo). However, in vitro tests have shown a poor correlation with in vivo studies. There is therefore a need of a more reliable methodology to evaluate the biological properties of biomaterials in vitro.This project aims to develop a microfluidic device that can be used to evaluate the biological properties of biomaterials both under mechanical cues (shear-stress and mechanical load) and inflammatory cues, therefore providing a more realistic picture of the biological performance of biomaterials. These systems will be used to study at real-time how cells respond to bioceramics with different chemistry and roughness. In particular, the differentiation of pre-osteoblasts, the activation of inflammatory cells, and how inflammatory cues may direct multipotent cells towards the osteogenic lineage will be studied in real-time.This microfluidic device will represent a reliable and efficient screening platform of the biological properties of bioceramics, making the path from the lab to the society shorter and safer. On top of that, it will enlighten the design of new "smart" bioceramics, which can turn inflammatory cues into a benefit to stimulate the new bone formation.