Anammoxosomens ursprung och evolution

Tidsperiod: 2019-01-01 till 2022-12-31

Projektledare: Siv Andersson

Finansiär: Vetenskapsrådet

Bidragstyp: Projektbidrag

Budget: 3 600 000 SEK

Mitochondria and chloroplasts are organelles in eukaryotic cells involved in respiration and photosynthesis, respectively. Until recently, no corresponding type of organelle had been described in bacteria. However, we now know that bacteria involved in anaerobic ammonium oxidation have organelles called anammoxosomes, which serve as their power stations. The aim of this project is to advance our knowledge about the origin and evolution of these remarkable bacterial organelles using bioinformatics, ecological and experimental approaches. Comparative genomics will be used to screen for adaptive traits that are unique to this group of bacteria. In parallel, we will study the mechanisms whereby these traits have emerged. To this end, the frequencies of duplications, horizontal gene transfer, domain fusions, fissions and rearrangements will be estimated. Innovations related to bioenergetic processes, iron metabolism, intracellular protein sorting systems and transenvelope-spanning protein complexes will be selected for further in-depth analyses. The long-term goal of this project is to develop a model that describes the evolutionary origin of the anammoxosome.