Att skapa ett immunologiskt skydd för transplantation av insulinproducerande celler med hjälp av bioteknologiska strategier

Tidsperiod: 2020-01-01 till 2021-12-31

Projektledare: Joey Lau, Joey Lau Börjesson

Medarbetare: Yuji Teramura, Per Ola Carlsson, Per-Ola Carlsson, Natalia Ferraz, Albert Mihranyan

Finansiär: Vetenskapsrådet

Bidragstyp: Stöd till forskningsmiljö

Budget: 700 000 SEK

This joint proposal envisages to develop an islet encapsulated bioengineered construct through an innovative design philosophy for transplantation purposes in type 1 diabetes. Pancreatic islets will firstly be encapsulated in a matrix containing factors that promote survival of islets following sheathing with a nanoporous immunoisolating membrane integrated with a pericapsular fibrotic overgrowth inhibiting nanotextile. Factors promoting vascularization and immune-protection will be bioengineered for sustained release on the construct´s outer periphery, by a combination of electrospinning with weaving technology and hydrogel formation. The technology of the construct, which is established by the Indian side, has not been applied for islets. The Swedish side has extensive experience in islet biology and in the islet transplantation area. Thus, this network grant is excellent for establishing a new collaboration between the Indian and Swedish research group. The Indian side will bioengineer the islet encapsulated construct by utilizing their expertise in biomaterial fabrication (time table: continuous development), while the Swedish side will evaluate the biocompatibility of the different components of the construct with islets (6-12 months) following implementation of the islet encapsulated construct in vivo (12-24 months). The inputs gained through these collaborations will foster development of products with translational value in the future.