En ny lågbrusig Si nanosensor för snabba antibiotikaresistenstester

Tidsperiod: 2020-01-01 till 2023-12-31

Projektledare: Zhen Zhang

Finansiär: Vetenskapsrådet

Bidragstyp: Projektbidrag

Budget: 4 400 000 SEK

The proposed project aims at developing a novel low-noise Silicon nanowire ion sensor for rapid antibiotic susceptibility tests. The extremely low sensor noise will be achieved by completely replacing the noisy oxide/Si interface in the device channel with low-noise Schottky junction. This novel sensor is expected to be capable of determining the susceptibility of antibiotics within one hour, by monitoring bacterial growth in the presence of different antibiotics in real-time. To do this we will base on the fact that the metabolic products of bacterial growth changes the pH of the growth media; and the pH change can be accurately measured using our new low noise sensor. The success of this project will enable quick selection of right drugs to treat infections in early but critical stage. It can also accelerate and facilitate the development of new effective antibiotics. This project will pave the way to use advanced semiconductor technology in novel biomedical applications of significant societal importance. The project will be supported by a research group in bacteria biology and external partners from industry. The project is divided into 3 well defined and interrelated work packages. There will be a new PhD student and a part time researcher in this project.