Elham Rostami
Forskare vid Institutionen för medicinska vetenskaper; Förvärvade hjärnskador
- E-post:
- elham.rostami@uu.se
- Besöksadress:
- Akademiska sjukhuset, ingång 40, 5 tr
751 85 UPPSALA - Postadress:
- Akademiska sjukhuset, ingång 40, 5 tr
751 85 UPPSALA
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Kort presentation
I’m a neurosurgeon and associate professor in neurosurgery since 2017. My main research area is traumatic brain injury (TBI) and subarachnoid hemorrhage.
Our group has also focus on the pathology of craniopharyngioma and treatment possibilities with targeted therapy.
Nyckelord
- traumatic brain injury
Forskning
Our team is aiming to understand the underlying pathology in different types of TBI as well as improve prediction in outcome. We use multimodal monitoring including microdialysis in the management of TBI patients and use data generated from these monitoring to identify important predictors in outcome. Our preclinical studies include different experimental TBI models, patients specific iPSC and genetic analysis. My main goal is to identify important prognostic markers to understand why some people recover better than others and what role our genetic background plays.
Other research interests are subarachnoid hemorrhage, Craniopharyngima, Cerebrospinal fluid dynamic disturbances.
Publikationer
Senaste publikationer
- Increased Incidence and Mortality of Civilian Penetrating Traumatic Brain Injury in Sweden (2024)
- Early management of adult traumatic spinal cord injury in patients with polytrauma (2024)
- Extracellular vesicles in plasma and cerebrospinal fluid in patients with COVID-19 and neurological symptoms (2024)
- Prognostic performance of blood neurofilament light chain protein in hospitalized COVID-19 patients without major central nervous system manifestations (2023)
- Central nervous system biomarkers GFAp and NfL associate with post-acute cognitive impairment and fatigue following critical COVID-19 (2023)
Alla publikationer
Artiklar
- Increased Incidence and Mortality of Civilian Penetrating Traumatic Brain Injury in Sweden (2024)
- Early management of adult traumatic spinal cord injury in patients with polytrauma (2024)
- Extracellular vesicles in plasma and cerebrospinal fluid in patients with COVID-19 and neurological symptoms (2024)
- Prognostic performance of blood neurofilament light chain protein in hospitalized COVID-19 patients without major central nervous system manifestations (2023)
- Central nervous system biomarkers GFAp and NfL associate with post-acute cognitive impairment and fatigue following critical COVID-19 (2023)
- The management of severe traumatic brain injury in the initial postinjury hours (2023)
- Huge variability in restrictions of mobilization for patients with aneurysmal subarachnoid hemorrhage - A European survey of practice (2023)
- Evaluation of Miethke M.scio Device Implantation for Intracranial Pressure Monitoring in Patients with Cerebrospinal Fluid Disorders (2023)
- Access to Rehabilitation After Hospitalization for Traumatic Brain Injury (2023)
- Interleukin-1 Receptor Antagonist as Therapy for Traumatic Brain Injury (2023)
- Myoclonus in patients with COVID-19 (2023)
- Prehospital transportation of severe penetrating trauma victims in Sweden during the past decade (2023)
- Prehospital and emergency department airway management of severe penetrating trauma in Sweden during the past decade (2023)
- Higher Intracranial Pressure Variability is Associated with Lower Cerebrovascular Resistance in Aneurysmal Subarachnoid Hemorrhage (2023)
- Cerebral Microdialysis Monitoring of Energy Metabolism: Relation to Cerebral Blood Flow and Oxygen Delivery in Aneurysmal Subarachnoid Hemorrhage (2023)
- Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in the Serum and Cerebrospinal Fluid of Patients With Coronavirus Disease 2019 and Neurological Symptoms (2022)
- The extent of neuroradiological findings in COVID-19 shows correlation with blood biomarkers, Glasgow coma scale score and days in intensive care (2022)
- Protein Expression Profile of ACE2 in the Normal and COVID-19-Affected Human Brain. (2022)
- Prognosis in moderate-severe traumatic brain injury in a Swedish cohort and external validation of the IMPACT models (2022)
- Cerebral Blood Flow and Oxygen Delivery in Aneurysmal Subarachnoid Hemorrhage (2022)
- Hyperglycolysis as a common cause for elevated lactate in subarachnoid hemorrhage (2021)
- CBF changes and cerebral energy metabolism during hypervolemia, hemodilution, and hypertension therapy in patients with poor-grade subarachnoid hemorrhage (2021)
- Critical illness polyneuropathy, myopathy and neuronal biomarkers in COVID-19 patients (2021)
- The Role of BDNF in Experimental and Clinical Traumatic Brain Injury (2021)
- Incidence, Demographics, and Outcomes of Penetrating Trauma in Sweden During the Past Decade (2021)
- Acute disseminated encephalomyelitis with delayed onset and feasibility of the Miethke shunt and sensor reservoir system (2021)
- Cystoventricular Drainage of Intracranial Arachnoid Cysts in Adults (2021)
- Autoimmune Encephalitis Presenting With Malignant Catatonia in a 40-Year-Old Male Patient With COVID-19 (2021)
- Indirect immunofluorescence for detecting anti-neuronal autoimmunity in CSF after COVID-19-Possibilities and pitfalls (2021)
- Editorial (2021)
- Arterial Oxygenation in Traumatic Brain Injury (2021)
- Systemic Hyperthermia in Traumatic Brain Injury—Relation to Intracranial Pressure Dynamics, Cerebral Energy Metabolism, and Clinical Outcome (2021)
- Autoregulatory or Fixed Cerebral Perfusion Pressure Targets in Traumatic Brain Injury (2021)
- Biomarkers for central nervous system injury in cerebrospinal fluid are elevated in COVID-19 and associated with neurological symptoms and disease severity (2021)
- How Can a Punch Knock You Out? (2020)
- Histopathology of Parasellar Neoplasms (2020)
- Cerebral Blood Flow Measurement in Healthy Children and Children Suffering Severe Traumatic Brain Injury (2020)
- Arterial lactate in traumatic brain injury (2020)
- Mild hyperventilation in traumatic brain injury (2020)
- Intracranial Pressure Dynamics and Cerebral Vasomotor Reactivity in Coronavirus Disease 2019 Patient With Acute Encephalitis (2020)
- Association of the bleeding time test with aspects of traumatic brain injury in patients with alcohol use disorder (2020)
- Acute necrotizing encephalopathy with SARS-CoV-2 RNA confirmed in cerebrospinal fluid (2020)
- Continuous EEG monitoring after brain tumor surgery (2019)
- Temporal Dynamics of Cerebral Blood Flow During the Acute Course of Severe Subarachnoid Hemorrhage Studied by Bedside Xenon-Enhanced CT (2019)
- Targeted treatment of papillary craniopharyngiomas harboring BRAF V600E mutations (2019)
- High Arterial Glucose is Associated with Poor Pressure Autoregulation, High Cerebral Lactate/Pyruvate Ratio and Poor Outcome Following Traumatic Brain Injury (2019)
- Hemodynamic Disturbances in the Early Phase After Subarachnoid Hemorrhage (2018)
- Effect of HHH-Therapy on Regional CBF after Severe Subarachnoid Hemorrhage Studied by Bedside Xenon-Enhanced CT (2018)
- Early low cerebral blood flow and high cerebral lactate (2018)
- Increased risk of critical CBF levels in SAH patients with actual CPP below calculated optimal CPP (2017)
- The Correlation between Cerebral Blood Flow Measured by Bedside Xenon-CT and Brain Chemistry Monitored by Microdialysis in the Acute Phase following Subarachnoid Hemorrhage (2017)
- Recurrent papillary craniopharyngioma with BRAFV600E mutation treated with neoadjuvant-targeted therapy. (2017)
- Bedside Xenon-CT Shows Lower CBF in SAH Patients with Impaired CBF Pressure Autoregulation as Defined by Pressure Reactivity Index (PRx) (2016)
- Traumatic Brain Injury Models in Animals. (2016)
- Consensus statement from the 2014 International Microdialysis Forum (2015)
- Time-Dependent Changes in Serum Level of Protein Biomarkers after Focal Traumatic Brain Injury (2015)
- Glucose and the injured brain-monitored in the neurointensive care unit (2014)
- Imaging of cerebral blood flow in patients with severe traumatic brain injury in the neurointensive care (2014)
- Monitoring of Cerebral Blood Flow and Metabolism Bedside in Patients with Subarachnoid Hemorrhage - A Xenon-CT and Microdialysis Study (2014)
- Alteration in BDNF and its receptors, full-length and truncated TrkB and p75NTR following penetrating traumatic brain injury (2014)
- The terminal pathway of the complement system is activated in focal penetrating but not in mild diffuse traumatic brain injury (2013)
- Brain metabolism and oxygenation in healthy pigs receiving hypoventilation and hyperoxia (2013)
- A Model for Mild Traumatic Brain Injury that Induces Limited Transient Memory Impairment and Increased Levels of Axon Related Serum Biomarkers (2012)
- Mechanisms of blast induced brain injuries, experimental studies in rats (2011)
- On acute gene expression changes after ventral root replantation. (2011)
- Monitoring of glucose in brain, adipose tissue, and peripheral blood in patients with traumatic brain injury (2011)
- BDNF polymorphism predicts general intelligence after penetrating traumatic brain injury (2011)
- Evidence of an inferior total-order planning strategy in patients with frontotemporal dementia. (2007)
- Microdialysis in neurointensive care. (2004)
Böcker
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