Oscar Verho
Universitetslektor vid Institutionen för läkemedelskemi; Läkemedelsdesign och läkemedelsutveckling
- E-post:
- oscar.verho@ilk.uu.se
- Besöksadress:
- Biomedicinskt Centrum BMC, Husargatan 3
- Postadress:
- Box 574
751 23 UPPSALA
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Kort presentation
Oscar Verho disputerade 2014 under handledning av Prof. Jan-Erling Bäckvall och blev universitetslektor vid Institutionen för Läkemedelskemi 2022. Hans forskning fokuserar på utformningen av nya syntetiska metoder som kan underlätta syntesen av bioaktiva molekyler och stödja forskning inom kemisk biologi och läkemedelsutveckling. Detta inkluderar forskning både fokuserat på nya elektrokatalyserade C-H funktionaliseringsmetoder och DNA-kodade bibliotek.
Nyckelord
- c-h functionalization
- dna-encoded libraries
- drug discovery
- electrochemistry
- organic synthesis
Forskning
Currently, my group focuses on the design of new synthetic methodologies that can be used for the synthesis of biologically active compounds and small molecule libraries. Here, much of our recent research has been centered on 8-aminoquinoline directed C-H functionalization, as it constitutes a very powerful strategy for rapidly building up molecular complexity. My group is also fascinated by new techniques that can enable expedient synthesis and screening of compound libraries for drug discovery applications. Here, we are currently collaborating with the SciLifeLab in the design of different DNA encoded compound libraries.
Publikationer
Senaste publikationer
- Bifunctional and regenerable molecular electrode for water electrolysis at neutral pH (2023)
- Cobalt Electrocatalyst on Fluorine Doped Carbon Cloth - a Robust and Partially Regenerable Anode for Water Oxidation (2022)
- Electrochemical Palladium-Catalyzed Oxidative Carbonylation-Cyclization of Enallenols (2022)
- The Impact of Ligand Carboxylates on Electrocatalyzed Water Oxidation (2021)
- A Study of an 8-Aminoquinoline-Directed C(sp(2))-H Arylation Reaction on the Route to Chiral Cyclobutane Keto Acids from Myrtenal (2021)
Alla publikationer
Artiklar
- Bifunctional and regenerable molecular electrode for water electrolysis at neutral pH (2023)
- Cobalt Electrocatalyst on Fluorine Doped Carbon Cloth - a Robust and Partially Regenerable Anode for Water Oxidation (2022)
- Electrochemical Palladium-Catalyzed Oxidative Carbonylation-Cyclization of Enallenols (2022)
- The Impact of Ligand Carboxylates on Electrocatalyzed Water Oxidation (2021)
- A Study of an 8-Aminoquinoline-Directed C(sp(2))-H Arylation Reaction on the Route to Chiral Cyclobutane Keto Acids from Myrtenal (2021)
- Investigation of the Deactivation and Reactivation Mechanism of a Heterogeneous Palladium(II) Catalyst in the Cycloisomerization of Acetylenic Acids by In Situ XAS (2021)
- Identification of unique and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries
Kapitel
