Rasel Al-Amin
Gästforskare vid Institutionen för immunologi, genetik och patologi; Forskningsprogram: Molekylära verktyg och funktionsgenomik; Forskargrupp Ulf Landegren
- E-post:
- rasel.al-amin@igp.uu.se
- Besöksadress:
- BMC, Husargatan 3
751 22 Uppsala - Postadress:
- Box 815
751 08 Uppsala
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Forskning
Rasel Al-Amin has a diverse and accomplished academic and professional background. Growing up in Bangladesh, he earned a Bachelor's Degree in Pharmacy from the University of Rajshahi. In 2007, he moved to Sweden to pursue a Master’s in Chemistry and Chemical Engineering at the Royal Institute of Technology (KTH) in Stockholm. After a research stint at the Karolinska Institute, he joined Uppsala University’s molecular tools research unit in 2011 for his PhD studies in Molecular Medicine under Professor Ulf Landegren, completing his PhD in March 2019.
Post-PhD, he co-founded PharmaPrecision AB, a biotech start-up focusing on spatial in situ target-engagement technology. His research expertise includes developing molecular assays for drug discovery and precision proteomics, with a strong background in oligonucleotide-based molecular assays, biochemical and cellular drug discovery, oligonucleotide chemistry, and affinity-based proteomics.
His work has been published in prestigious journals like Nature Methods, Nucleic Acids Research, Diabetologia, Analytical Chemistry, and Communication Biology, and he has presented at notable conferences worldwide. He also held a Thunberg Fellowship at the Swedish Collegium for Advanced Study (SCAS).
In February 2023, he joined the Department of Chemistry at the University of Oxford as a Genomics Medicine Scientist, focusing on therapeutic oligonucleotides targeting mRNA in genomics medicine. He leads research projects in drug discovery, proteomics, bio-conjugation, and molecular assays development, and has significant experience in supervising PhD students and technical personnel.
His passion for research, innovation, and entrepreneurship is evident through his collaborations with academic groups, leadership roles at PharmaPrecision AB, and numerous high-impact publications. He has also taken career breaks to support his family and has completed various courses for commercialization of life science and health care research, business startup and development, intellectual property rights, executive leadership, and project management. In his current position with the Oxford University, he is committed to advancing the genomics medicine field.
Publikationer
Senaste publikationer
- Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ (2022)
- Sensitive protein detection using site-specifically oligonucleotide-conjugated nanobody reagents (2022)
- Sensitive Measurement of Drug-Target Engagement by a Cellular Thermal Shift Assay with Multiplex Proximity Extension Readout (2021)
- Image-based high-throughput mapping of TGF-beta-induced phosphocomplexes at a single-cell level (2021)
- Molecular Approaches to Explore Drug-Target Interactions (2019)
Alla publikationer
Artiklar
- Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ (2022)
- Sensitive protein detection using site-specifically oligonucleotide-conjugated nanobody reagents (2022)
- Sensitive Measurement of Drug-Target Engagement by a Cellular Thermal Shift Assay with Multiplex Proximity Extension Readout (2021)
- Image-based high-throughput mapping of TGF-beta-induced phosphocomplexes at a single-cell level (2021)
- A myopic perspective on the future of protein diagnostics (2018)
- Spatial control of membrane receptor function using ligand nanocalipers (2014)
- Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells (2013)
- Sensitive Measurement of Cellular Drug-Target Engagement Using Multiplex Proximity Extension Assays
- Target Engagement-Mediated Amplification for Monitoring Drug-Target Interactions in Situ
- High-throughput in situ mapping of phosphorylated protein complexes across the cell cycle and in response to drugs