Pharmaceutical Physics
Description
In the research area of pharmaceutical physics, the design, manufacturing and performance of drug-delivery systems are studied. An overall theme for this research is to clarify how raw materials, formulation and manufacturing affect the functional properties and quality of drug-delivery systems. The work is mainly focused on drug-delivery systems intended for oral and pulmonary administration.
The research currently has two main directions: (1) experimental and theoretical studies of the behavior of granular materials (powder mechanics) and (2) experiments and modeling of the delivery, dissolution and release of drugs, mainly to the lung.
A consistent theme for the group's activities in powder mechanics is the development of new methods for simulating the behavior of granular materials, especially when these are exposed to relatively high applied pressures such as during manufacturing of tablets.
The research group leader (Göran Frenning) leads a work package in the competence center SweDeliver dedicated to drug delivery to the lung. A large part of the group's activities therefore takes place within the framework of SweDeliver. More information about this and the included projects can be found here.
Publications
Single-particle fabric tensors for assemblies of spherical particles
Part of Computer Methods in Applied Mechanics and Engineering, 2024
Part of European Journal of Pharmaceutical Sciences, 2024
Part of Powder Technology, 2023
A new modelling approach for dissolution of polydisperse powders
Part of International Journal of Pharmaceutics, 2023
A Voronoi strain-based method for granular materials and continua
Part of Computational particle mechanics, p. 427-443, 2023
Segregation in inhalable powders: Quantification of the effect of vibration on adhesive mixtures
Part of European journal of pharmaceutics and biopharmaceutics, p. 107-119, 2023
Part of International Journal of Pharmaceutics, 2023
Part of Powder Technology, 2023
Effect of fluid velocity and particle size on the hydrodynamic diffusion layer thickness
Part of European journal of pharmaceutics and biopharmaceutics, p. 1-10, 2022
Part of COMPUTATIONAL PARTICLE MECHANICS, p. 1105-1118, 2022
Part of Molecular Pharmaceutics, p. 3114-3124, 2022
- DOI for Characterization of Membrane-Type Dissolution Profiles of Clinically Available Orally Inhaled Products Using a Weibull Fit and a Mechanistic Model
- Download full text (pdf) of Characterization of Membrane-Type Dissolution Profiles of Clinically Available Orally Inhaled Products Using a Weibull Fit and a Mechanistic Model
Part of International Journal of Pharmaceutics, 2022
Part of International Journal of Pharmaceutics, 2021
Part of Powder Technology, p. 230-239, 2021
Part of Powder Technology, p. 299-305, 2021
Hyaluronic Acid Hydrogels for Controlled Pulmonary Drug Delivery-A Particle Engineering Approach
Part of Pharmaceutics, 2021
Part of Pharmaceutics, 2021
Part of Journal of Colloid and Interface Science, p. 92-100, 2020
Part of Chemical Engineering Science: X, 2020
Model for the Analysis of Membrane-Type Dissolution Tests for Inhaled Drugs
Part of Molecular Pharmaceutics, p. 2426-2434, 2020
Part of International Journal of Pharmaceutics, p. 130-137, 2019
Part of Powder Technology, p. 74-81, 2019
Part of International Journal of Pharmaceutics, p. 148-160, 2019
Part of International Journal of Pharmaceutics, p. 143-156, 2018
Part of International Journal of Pharmaceutics, p. 120-131, 2018
Peptide loaded microgels as antimicrobial surface coatings
Part of Abstracts of Papers of the American Chemical Society, 2017
Part of Powder Technology, p. 347-355, 2017
Computational fluid dynamics (CFD) studies of a miniaturized dissolution system
Part of International Journal of Pharmaceutics, p. 274-281, 2017
Part of Chemical engineering research & design, p. 183-191, 2016
Electrostatic Swelling Transitions in Surface-Bound Microgels
Part of ACS Applied Materials and Interfaces, p. 27129-27139, 2016
Part of Powder Technology, p. 79-87, 2016
Part of MethodsX, p. 79-90, 2015
An apparatus for confined triaxial testing of single particles
Part of Powder Technology, p. 121-127, 2015
Towards a mechanistic contact model for elastoplastic particles at high relative densities
Part of Finite elements in analysis and design (Print), p. 56-60, 2015
Part of Powder Technology, p. 257-264, 2015
Chain and Pore-Blocking Effects on Matrix Degradation in Protein-Loaded Microgels
Part of Biomacromolecules, p. 3671-3678, 2014
Factors Affecting Enzymatic Degradation of Microgel-Bound Peptides
Part of Biomacromolecules, p. 2317-2325, 2013
Part of European Journal of Pharmaceutical Sciences, p. 241-250, 2013
- DOI for The influence of rolling friction on the shear behaviour of non-cohesive pharmaceutical granules: An experimental and numerical investigation
- Download full text (pdf) of The influence of rolling friction on the shear behaviour of non-cohesive pharmaceutical granules: An experimental and numerical investigation
Part of International Journal of Pharmaceutics, p. 3-12, 2013
- DOI for The degree of compression of spherical granular solids controls the evolution of microstructure and bond probability during compaction
- Download full text (pdf) of The degree of compression of spherical granular solids controls the evolution of microstructure and bond probability during compaction
Part of Materials letters (General ed.), p. 365-368, 2013
- DOI for Towards a mechanistic model for the interaction between plastically deforming particles under confined conditions: A numerical and analytical analysis
- Download full text (pdf) of Towards a mechanistic model for the interaction between plastically deforming particles under confined conditions: A numerical and analytical analysis
Part of International Journal of Pharmaceutics, p. 295-299, 2013
Part of Powder Technology, p. 249-256, 2012
An experimental evaluation of an effective medium based compaction equation
Part of European Journal of Pharmaceutical Sciences, p. 49-55, 2012
A model describing the internal structure of core/shell hydrogels
Part of Soft Matter, p. 10327-10338, 2011
Part of International Journal of Pharmaceutics, p. 88-99, 2011
The Release of Catanionic Mixtures Embedded in Gels: An Approximate Analytical Analysis
Part of AIChE Journal, p. 1402-1408, 2011
Part of European Journal of Pharmaceutical Sciences, p. 199-209, 2011
Part of Journal of Pharmaceutical Sciences, p. 4338-4348, 2011
Effect of spherical-agglomerate strength on the distribution of force during uniaxial compression
Part of Powder Technology, p. 283-290, 2011
Compression mechanics of granule beds: A combined finite/discrete element study
Part of Chemical Engineering Science, p. 2464-2471, 2010