UDOPP
The Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP) is a pharmaceutical and ADME platform, physically located in the laboratories of Prof. Per Artursson at Department of Pharmacy at Uppsala University and offer ADME related services to researchers in academia and biotech.
UDOPP
Our vision
Our vision is to add value to all stages of pharmaceutical and ADMET related research and thereby increase the number of drug candidates which can be successfully developed to marketed drugs.
The team
We are a group of scientists with expertise in preclinical drug discovery and development. The unit has experience in working with small molecules, therapeutics proteins and peptides, and most recently, oligonucleotides. UDOPP uses a state-of-the-art laboratory and cutting-edge research to help Swedish academic drug discovery projects in the optimization of hit compound series and deliver lead compounds and candidate drugs of the highest possible quality. We add scientific value to all stages of the preclinical drug discovery and development process.
The projects
UDOPP is a part of the Drug Discovery and Development platformen (DDD) at SciLifeLab, in the form of ADME of Therapeutics (ADMEoT). The ADMEoT unit is contributing to two antibacterial drug discovery platforms: 1) ENABLE2 aiming for proof-of-concept in animal models of new antibacterial hits, and 2) JPIAMR/MURYXIN, which aims to improve the therapeutic window of clinically used cyclic peptide antibiotics. UDOPP is also affiliated with the Innovative Medicines Initiative (IMI) project - ConcePTION – as a team responsible for bioanalysis of human samples and population PK (popPK) modelling.
Our services and assays
We offer a large number of analyses of small molecules, proteins and oligonucleotides.
Collaborations
We collaborate with both researchers within academia and biotech. When time permits, we sometimes also offer protects to students.
Equipment
We have a well-equipted lab for ADME related analsyses:
Mass spektrometers:
Acquity UPLC - Xevo TQ-S micro (Waters 2017)
Acquity UPLC - Xevo TQ-S micro (Waters 2023)
Acquity UPLC- QToF Synapt G2-Si (Waters 2020)
Acquity Premier UPLC - QToF Synapt XS (ETD) (Waters 2022)
nanoLC- Q-Exactive HF Orbitrap (Thermo 2017)
Robots:
Liquid handling robot Hamilton Star (Hamilton 2014)
Liquid handling robot TECAN Evo (Tecan 2004)
Other equipment
Access to a cell culture lab
Plate washer HydroSpeed (Tecan)
