Doctoral thesis and Research articles

A stargazer's guide to neurodegeneration: Astrocytes' role in the propagation of pathological proteins

Mothes, Tobias

2024

Doctoral thesis, comprehensive summary

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Harnessing the molecular Trojan horse: Evaluating properties of preclinical Aβ immunoPET radioligands for optimized brain delivery via the transferrin receptor

Bonvicini, Gillian

2023

Doctoral thesis, comprehensive summary

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One-click away from higher contrast: Improvements to peripheral clearance for same-day immunoPET in Alzheimer’s disease

Schlein, Eva

2023

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Visualising neurodegeneration in the living brain: Preclinical evaluation of PET radioligands

Xiong, Mengfei

2023

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Factors influencing transferrin receptor-mediated brain delivery: Evaluating preclinical antibody-based proteins for PET imaging in Alzheimer’s disease

Faresjö Melander, Rebecca

2023

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Pathophysiological effects of alpha-synuclein on SNARE complex proteins in models of alpha-synucleinopathies

Brolin, Emma

2022

Doctoral thesis, comprehensive summary

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Ex‘PLA’ining the progression of pathological proteins in Alzheimer’s and Parkinson’s diseases: see(d)ing is believing

Behere, Anish

2022

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CRISPR/Cas9-based therapies and the role of astrocytes in Alzheimer’s disease and Parkinson’s disease

Konstantinidis, Evangelos

2022

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Brain distribution of a bispecific antibody targeting Aβ

Tobias, Gustavsson

2022

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Characterization of the novel “Uppsala mutation” causing a familial form of early onset Alzheimer’s disease

Pagnon de la Vega, María

2021

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Preclinical PET imaging and therapy of Alzheimer's disease

Meier, Silvio R.

2021

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The role of glial cells in alpha-synuclein pathology: Focus on degradation, cell-to-cell propagation and inflammation

Rostami, Jinar

2020

Doctoral thesis, comprehensive summary

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Characterization of Physiological and Pathological Alpha-Synuclein: Implications for Parkinson’s Disease and Related Disorders

Almandoz Gil, Leire

2018

Doctoral thesis, comprehensive summary

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Cellular responses to amyloid-beta protofibrils: Focus on astrocytes, extracellular vesicles and antibody treatment

Nikitidou, Elisabeth

2018

Doctoral thesis, comprehensive summary

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Preclinical PET imaging of Alzheimer's disease progression

Fang, Xiaotian T.

2017

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Alpha-Synuclein Oligomers: Cellular Mechanisms and Aspects of Antibody Treatment

Gustafsson, Gabriel

2017

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Amyloid-β Protofibrils in Alzheimer´s Disease: Focus on Antibodies, Inflammation and Astrocytes

Söllvander, Sofia

2015

Doctoral thesis, comprehensive summary

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Therapeutic and functional studies in animal models of Alzheimer's disease

Gumucio, Astrid

2014

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Studies of α-synuclein Oligomers-with Relevance to Lewy Body Disorders

Fagerqvist, Therese

2013

Doctoral thesis, comprehensive summary

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Characterization of α-synuclein oligomers: Implications for Lewy Body Disorders

Näsström, Thomas

2011

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Heparan Sulfate in the Amyloidosis and Inflammation of Alzheimer’s Disease

O'Callaghan, Paul

2011

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Aβ Conformation Dependent Antibodies and Alzheimer's Disease

Sehlin, Dag

2010

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Modeling Amyloid-β Pathology in Alzheimer’s Disease Using the Arctic Mutation

Philipson, Ola

2010

Doctoral thesis, comprehensive summary

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Soluble amyloid-β aggregates in Alzheimer’s disease

Englund, Hillevi

2009

Doctoral thesis, comprehensive summary

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Targeting Early Stages of Alzheimer’s Disease in a Transgenic Model

Lord, Anna

2009

Doctoral thesis, comprehensive summary

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Molecular Mechanisms of Frontotemporal Lobar Degeneration

Skoglund, Lena

2009

Doctoral thesis, comprehensive summary

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Genetic Studies of Alzheimer's Disease

Blom, Elin

2008

Doctoral thesis, comprehensive summary

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Amyloid-β Protofibril Formation and Neurotoxicity: Implications for Alzheimer’s Disease

Johansson, Ann-Sofi

2007

Doctoral thesis, comprehensive summary

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Pathogenic Mechanisms of the Arctic Alzheimer Mutation

Sahlin, Charlotte

2007

Doctoral thesis, comprehensive summary

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Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms

Beretta, Chiara; Svensson, Elina; Dakhel, Abdulkhalek; Zyśk, Marlena et al.

Part of Molecular and Cellular Neuroscience, 2024

Article in journal

• DOI for Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms
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Comparing in vitro affinity measurements of antibodies to TfR1: Surface plasmon resonance versus on-cell affinity

Bonvicini, Gillian; Singh, Sunitha; Nygren, Patrik; Xiong, Mengfei et al.

Part of Analytical Biochemistry, 2024

Article in journal

• DOI for Comparing in vitro affinity measurements of antibodies to TfR1: Surface plasmon resonance versus on-cell affinity
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Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment

Eltom, Khalid; Mothes, Tobias; Libard, Sylwia; Ingelsson, Martin et al.

Part of Acta neuropathologica communications, 2024

Article in journal

• DOI for Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment
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Association of MGMT and BIN1 genes with Alzheimer's disease risk across sex and APOE ε4 status

Le Borgne, Julie; Amouyel, Philippe; Andreassen, Ole; Frikke-Schmidt, Ruth et al.

Part of Alzheimer's & Dementia, p. 2282-2284, 2024

Article in journal

• DOI for Association of MGMT and BIN1 genes with Alzheimer's disease risk across sex and APOE ε4 status
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Spatial Neurolipidomics at the Single Amyloid-β Plaque Level in Postmortem Human Alzheimer's Disease Brain

Michno, Wojciech; Bowman, Andrew; Jha, Durga; Minta, Karolina et al.

Part of ACS Chemical Neuroscience, p. 877-888, 2024

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• DOI for Spatial Neurolipidomics at the Single Amyloid-β Plaque Level in Postmortem Human Alzheimer's Disease Brain
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Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion

Pagnon de la Vega, María; Syvänen, Stina; Giedraitis, Vilmantas; Hooley, Monique et al.

Part of Acta neuropathologica communications, 2024

Article in journal

• DOI for Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
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Validation of a web-based self-administered test for cognitive assessment in a Swedish geriatric setting

Rystedt, Einar; Moren, Jakob; Lindbäck, Johan; Tedim Cruz, Vitor et al.

Part of PLOS ONE, 2024

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• DOI for Validation of a web-based self-administered test for cognitive assessment in a Swedish geriatric setting
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Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody

Schlein, Eva; Andersson, Ken G.; Dallas, Tiffany; Syvänen, Stina et al.

Part of mAbs, 2024

Article in journal

• DOI for Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody
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Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET

Schlein, Eva; Rokka, Johanna; Odell, Luke R.; Lopes van den Broek, Sara et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2024

Article in journal

• DOI for Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET
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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Suzuki, Ken; Giedraitis, Vilmantas; Ingelsson, Martin; Lind, Lars et al.

Part of Nature, p. 347-357, 2024

Article in journal

• DOI for Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
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Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities

Söderberg, Linda; Johannesson, Malin; Gkanatsiou, Eleni; Nygren, Patrik et al.

Part of Scientific Reports, 2024

Article in journal

• DOI for Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities
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Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau

Banka, Vinay; Kelleher, Andrew; Sehlin, Dag; Hultqvist, Greta et al.

Part of Frontiers in nuclear medicine, 2023

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• DOI for Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau
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Levels of inflammatory cytokines MCP-1, CCL4, and PD-L1 in CSF differentiate idiopathic normal pressure hydrocephalus from neurodegenerative diseases

Braun, Madelen; Boström, Gustaf; Ingelsson, Martin; Kilander, Lena et al.

Part of Fluids and Barriers of the CNS, 2023

Article in journal

• DOI for Levels of inflammatory cytokines MCP-1, CCL4, and PD-L1 in CSF differentiate idiopathic normal pressure hydrocephalus from neurodegenerative diseases
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Altered Distribution of SNARE Proteins in Primary Neurons Exposed to Different Alpha-Synuclein Proteoforms

Brolin, Emma; Ingelsson, Martin; Bergström, Joakim; Erlandsson, Anna

Part of Cellular and molecular neurobiology, p. 3023-3035, 2023

Article in journal

• DOI for Altered Distribution of SNARE Proteins in Primary Neurons Exposed to Different Alpha-Synuclein Proteoforms
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Phosphorylated α-synuclein in skin Schwann cells: a new biomarker for multiple system atrophy

Donadio, Vincenzo; Incensi, Alex; Rizzo, Giovanni; Westermark, Gunilla T. et al.

Part of Brain, p. 1065-1074, 2023

Article in journal

• DOI for Phosphorylated α-synuclein in skin Schwann cells: a new biomarker for multiple system atrophy

Reduction of brain stem pathology and transient amelioration of early cognitive symptoms in transgenic mice treated with a monoclonal antibody against α-synuclein oligomers/protofibrils

Ekmark-Lewén, Sara; Aniszewska, Agata; Molisak, Agnieszka; Gumucio, Astrid et al.

Part of AGING BRAIN, 2023

Article in journal

• DOI for Reduction of brain stem pathology and transient amelioration of early cognitive symptoms in transgenic mice treated with a monoclonal antibody against α-synuclein oligomers/protofibrils
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Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody

Faresjö, Rebecca; Sehlin, Dag; Syvänen, Stina

Part of Fluids and Barriers of the CNS, 2023

Article in journal

• DOI for Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody
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Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease

Gustavsson, Tobias; Metzendorf, Nicole G.; Wik, Elin; Roshanbin, Sahar et al.

Part of Alzheimer's Research & Therapy, 2023

Article in journal

• DOI for Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease
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The amyloid-beta pathway in Alzheimer's disease: a plain language summary

Hampel, Harald; Hu, Yan; Hardy, John; Blennow, Kaj et al.

Part of Neurodegenerative Disease Management, p. 141-149, 2023

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• DOI for The amyloid-beta pathway in Alzheimer's disease: a plain language summary
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Long-term effects of amyloid-beta deposits in human iPSC-derived astrocytes

Konstantinidis, Evangelos; Dakhel, Abdulkhalek; Beretta, Chiara; Erlandsson, Anna

Part of Molecular and Cellular Neuroscience, 2023

Article in journal

• DOI for Long-term effects of amyloid-beta deposits in human iPSC-derived astrocytes
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Intracellular deposits of amyloid-beta influence the ability of human iPSC-derived astrocytes to support neuronal function

Konstantinidis, Evangelos; Portal, Benjamin; Mothes, Tobias J.; Beretta, Chiara et al.

Part of Journal of Neuroinflammation, 2023

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• DOI for Intracellular deposits of amyloid-beta influence the ability of human iPSC-derived astrocytes to support neuronal function
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The G51D SNCA mutation generates a slowly progressive alpha-synuclein strain in early-onset Parkinson's disease

Lau, Heather H. C.; Martinez-Valbuena, Ivan; So, Raphaella W. L.; Mehra, Surabhi et al.

Part of Acta neuropathologica communications, 2023

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• DOI for The G51D SNCA mutation generates a slowly progressive alpha-synuclein strain in early-onset Parkinson's disease
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Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Le Guen, Yann; Luo, Guo; Ambati, Aditya; Damotte, Vincent et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2023

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• DOI for Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
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Plasma Protein Profiling of Incident Cardiovascular Diseases: A Multisample Evaluation

Lind, Lars; Titova, Olga; Zeng, Rui; Zanetti, Daniela et al.

Part of CIRCULATION-GENOMIC AND PRECISION MEDICINE, 2023

Article in journal

• DOI for Plasma Protein Profiling of Incident Cardiovascular Diseases: A Multisample Evaluation
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Size matters: the impact of nucleus size on results from spatial transcriptomics

Mohammadi, Elyas; Chojnowska, Katarzyna; Bienkowski, Michal; Kostecka, Anna et al.

Part of Journal of Translational Medicine, 2023

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• DOI for Size matters: the impact of nucleus size on results from spatial transcriptomics
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Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology

Mothes, Tobias; Portal, Benjamin; Konstantinidis, Evangelos; Eltom, Khalid et al.

Part of Acta neuropathologica communications, 2023

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• DOI for Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology
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Genetic insights into resting heart rate and its role in cardiovascular disease

van de Vegte, Yordi; Eppinga, Ruben P.; van der Ende, M. Yldau; Hagemeijer, Yanick et al.

Part of Nature Communications, 2023

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• DOI for Genetic insights into resting heart rate and its role in cardiovascular disease
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Studies on alpha-synuclein and islet amyloid polypeptide interaction

Wang, Ye; Bergström, Joakim; Ingelsson, Martin; Westermark, Gunilla

Part of Frontiers in Molecular Biosciences, 2023

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• DOI for Studies on alpha-synuclein and islet amyloid polypeptide interaction
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Synaptic density in aging mice measured by [18F]SynVesT-1 PET

Xiong, Mengfei; Roshanbin, Sahar; Sehlin, Dag; Hansen, Hanne D. et al.

Part of NeuroImage, 2023

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• DOI for Synaptic density in aging mice measured by [18F]SynVesT-1 PET
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Cryo-EM of Aβ fibrils from mouse models find tg-APP_ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease

Zielinski, Mara; Peralta Reyes, Fernanda S; Gremer, Lothar; Schemmert, Sarah et al.

Part of Nature Neuroscience, p. 2073-2080, 2023

Article in journal

• DOI for Cryo-EM of Aβ fibrils from mouse models find tg-APP_ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease
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Amyloid-beta accumulation in human astrocytes induces mitochondrial disruption and changed energy metabolism

Zyśk, Marlena; Beretta, Chiara; Naia, Luana; Dakhel, Abdulkhalek et al.

Part of Journal of Neuroinflammation, 2023

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• DOI for Amyloid-beta accumulation in human astrocytes induces mitochondrial disruption and changed energy metabolism
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Modeling Parkinson's disease-related symptoms in alpha-synuclein overexpressing mice

Aniszewska, Agata; Bergström, Joakim; Ingelsson, Martin; Ekmark-Lewén, Sara

Part of Brain and Behavior, 2022

Article, review/survey

• DOI for Modeling Parkinson's disease-related symptoms in alpha-synuclein overexpressing mice
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New insights into the genetic etiology of Alzheimer's disease and related dementias

Bellenguez, Celine; Giedraitis, Vilmantas; Ingelsson, Martin; Lambert, Jean-Charles

Part of Nature Genetics, p. 412-436, 2022

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• DOI for New insights into the genetic etiology of Alzheimer's disease and related dementias
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Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping

Belloy, Michael E.; Eger, Sarah J.; Le Guen, Yann; Damotte, Vincent et al.

Part of Alzheimer's Research & Therapy, 2022

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• DOI for Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping
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ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer's disease with a bispecific, brain-penetrating fusion protein

Bonvicini, Gillian; Syvänen, Stina; Andersson, Ken G. G.; Haaparanta-Solin, Merja et al.

Part of Translational Neurodegeneration, 2022

Article in journal

• DOI for ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer's disease with a bispecific, brain-penetrating fusion protein
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A beta and tau prions feature in the neuropathogenesis of Down syndrome

Condello, Carlo; Maxwell, Alison M.; Castillo, Erika; Aoyagi, Atsushi et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2022

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• DOI for A beta and tau prions feature in the neuropathogenesis of Down syndrome

Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3

de la Rosa, Andres; Metzendorf, Nicole G.; Morrison, Jamie; Faresjö, Rebecca et al.

Part of Scientific Reports, 2022

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• DOI for Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3
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Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-A beta-Affibodies

Faresjö, Rebecca; Lindberg, Hanna; Stahl, Stefan; Lofblom, John et al.

Part of Pharmaceutical research, p. 1509-1521, 2022

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• DOI for Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-A beta-Affibodies
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Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers

Jansen, Ris E.; van der Lee, Sven J.; Gomez-Fonseca, Duber; de Rojas, Itziar et al.

Part of Acta Neuropathologica, p. 821-842, 2022

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• DOI for Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers
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Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's A beta amyloidosis

Jiang, Richeng; Smailovic, Una; Haytural, Hazal; Tijms, Betty M. et al.

Part of Acta neuropathologica communications, 2022

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• DOI for Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's A beta amyloidosis
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Brain pharmacokinetics of mono- and bispecific amyloid-beta antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis

Julku, Ulrika; Xiong, Mengfei; Wik, Elin; Roshanbin, Sahar et al.

Part of Fluids and Barriers of the CNS, 2022

Article in journal

• DOI for Brain pharmacokinetics of mono- and bispecific amyloid-beta antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis
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Advances in the development of new biomarkers for Alzheimer's disease

Klyucherev, Timofey O.; Olszewski, Pawel K.; Shalimova, Alena; Chubarev, Vladimir N. et al.

Part of Translational Neurodegeneration, 2022

Article, review/survey

• DOI for Advances in the development of new biomarkers for Alzheimer's disease
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CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease PSEN1 M146L mutation

Konstantinidis, Evangelos; Molisak, Agnieszka; Perrin, Florian; Streubel-Gallasch, Linn et al.

Part of Molecular Therapy Nucleic Acids, p. 450-461, 2022

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• DOI for CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease PSEN1 M146L mutation
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Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease

Le Guen, Yann; Belloy, Michael E.; Grenier-Boley, Benjamin; de Rojas, Itziar et al.

Part of JAMA Neurology, p. 652-663, 2022

Article in journal

• DOI for Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease

Mixed Pathologies in a Subject with a Novel PSEN1 G206R Mutation

Libard, Sylwia; Giedraitis, Vilmantas; Kilander, Lena; Ingelsson, Martin et al.

Part of Journal of Alzheimer's Disease, p. 1601-1614, 2022

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• DOI for Mixed Pathologies in a Subject with a Novel PSEN1 G206R Mutation
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Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Mahajan, Anubha; Spracklen, Cassandra N.; Zhang, Weihua; Ng, Maggie C. Y. et al.

Part of Nature Genetics, p. 560-572, 2022

Article in journal

• DOI for Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention

Meier, Silvio R.; Sehlin, Dag; Roshanbin, Sahar; Lim Falk, Victoria et al.

Part of Journal of Nuclear Medicine, p. 302-309, 2022

Article in journal

• DOI for ¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention
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Passive and receptor mediated brain delivery of an anti-GFAP nanobody

Meier, Silvio R.; Sehlin, Dag; Syvänen, Stina

Part of Nuclear Medicine and Biology, p. 128-134, 2022

Article in journal

• DOI for Passive and receptor mediated brain delivery of an anti-GFAP nanobody
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Mutation analysis of disease causing genes in patients with early onset or familial forms of Alzheimer’s disease and frontotemporal dementia

Pagnon de la Vega, María; Näslund, Carl; Brundin, RoseMarie; Lannfelt, Lars et al.

Part of BMC Genomics, 2022

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• DOI for Mutation analysis of disease causing genes in patients with early onset or familial forms of Alzheimer’s disease and frontotemporal dementia
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A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice

Rofo, Fadi; Meier, Silvio R.; Metzendorf, Nicole G.; Morrison, Jamie et al.

Part of NEUROTHERAPEUTICS, p. 1588-1602, 2022

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• DOI for A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice
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