Medical Epidemiology
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Photo: Mikael Wallerstedt
Our main research concern diseases and conditions in the ageing population, including fragility fractures, cardiovascular diseases and cancer, but we are involved in other areas of epidemiological research as well.
The Medical Epidemiology research group is based at the EpiHub (map), an office and network for epidemiological research within the the Disciplinary domain of Medicine and Pharmacy at Uppsala University. This facilitates fruitful interaction with different research groups aiming to jointly build a long term foundation for advanced epidemiological research.
Our main research concern diseases and conditions in the ageing population, including fragility fractures, cardiovascular diseases and cancer, but we are involved in other areas of epidemiological research as well. We combine traditional epidemiological methods with modern causal inference methods in observational studies and perform randomised intervention studies. Find out more about our research by browsing through our publication list.
SIMPLER
Karl Michaëlsson, head of Medical Epidemiology, is also director for the national research infrastructure SIMPLER, Swedish Infrastructure for Medical Population-Based Life-Course and Environmental Research (simpler4health.se) and much of our research is based on the cohorts included in SIMPLER. Since the end of 2018 the infrastructure is managed by a consortium consisting of Uppsala University, Karolinska Institutet, Chalmers University of Technology and Örebro University in collaboration with the County Councils in Uppsala, Västmanland and Örebro County.
The infrastructure's mission is to provide national and international researchers with data for studies on how dietary and lifestyle factors and genetics affect our health, especially during the latter part of life. The knowledge can for example be used to develop recommendations on diet and lifestyle, develop new markers fore easier and more accurate diagnosis of chronic diseases and their precursors and to develop new individualized treatments.
Funding
The research group has received funding from the Swedish Research Council (VR), the Swedish Research Council for Health, Working Life and Welfare (FORTE), the Swedish Heart-Lung Foundation, the Swedish Cancer Society, Hjärnfonden, and ALF.
Publications
Part of Environmental Science and Technology, p. 1036-1047, 2024
- DOI for OMICs Signatures Linking Persistent Organic Pollutants to Cardiovascular Disease in the Swedish Mammography Cohort
- Download full text (pdf) of OMICs Signatures Linking Persistent Organic Pollutants to Cardiovascular Disease in the Swedish Mammography Cohort
Markers of imminent myocardial infarction
Part of Nature Cardiovascular Research, 2024
- DOI for Markers of imminent myocardial infarction
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Part of Cell Death Discovery, 2024
- DOI for Role of PATJ in stroke prognosis by modulating endothelial to mesenchymal transition through the Hippo/Notch/PI3K axis
- Download full text (pdf) of Role of PATJ in stroke prognosis by modulating endothelial to mesenchymal transition through the Hippo/Notch/PI3K axis
Part of Journal of Autoimmunity, 2024
- DOI for Older age of celiac disease diagnosis and risk of autoimmune disease: A nationwide matched case-control study
- Download full text (pdf) of Older age of celiac disease diagnosis and risk of autoimmune disease: A nationwide matched case-control study
Part of Cancer Causes and Control, p. 367-376, 2024
- DOI for Combined associations of a healthy lifestyle and body mass index with colorectal cancer recurrence and survival: a cohort study
- Download full text (pdf) of Combined associations of a healthy lifestyle and body mass index with colorectal cancer recurrence and survival: a cohort study
Part of The Journal of Nutrition, Health & Aging, p. 100247-100247, 2024
Part of European Journal of Nutrition, 2024
Digestive System Diseases, Genetic Risk, and Incident Dementia: A Prospective Cohort Study
Part of American Journal of Preventive Medicine, p. 516-525, 2024
Part of BMC Medicine, 2024
- DOI for Genetic investigation into the broad health implications of caffeine: evidence from phenome-wide, proteome-wide and metabolome-wide Mendelian randomization
- Download full text (pdf) of Genetic investigation into the broad health implications of caffeine: evidence from phenome-wide, proteome-wide and metabolome-wide Mendelian randomization
Part of EBioMedicine, 2024
- DOI for Phenome-wide Mendelian randomization analysis reveals multiple health comorbidities of coeliac disease
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Part of American Journal of Epidemiology, p. 96-106, 2024
- DOI for Hypothetical 22-Year Intervention With the Dietary Approaches to Stop Hypertension and Risk of Heart Failure in a General Population
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Part of EBioMedicine, 2024
- DOI for Sedentary lifestyle, physical activity, and gastrointestinal diseases: evidence from mendelian randomization analysis
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Proteomic insights into modifiable risk of venous thromboembolism and cardiovascular comorbidities
Part of Journal of Thrombosis and Haemostasis, p. 738-748, 2024
- DOI for Proteomic insights into modifiable risk of venous thromboembolism and cardiovascular comorbidities
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Part of The journals of gerontology. Series A, Biological sciences and medical sciences, 2024
Healthy lifestyle and cancer survival: A multinational cohort study
Part of International Journal of Cancer, p. 1709-1718, 2024
- DOI for Healthy lifestyle and cancer survival: A multinational cohort study
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Design, Methods, and Participation in Riksmaten Young Children—A Swedish National Dietary Survey
Part of Current Developments in Nutrition, 2024
Part of Diabetologia, 2024
DNA methylation and stroke prognosis: an epigenome-wide association study
Part of Clinical Epigenetics, 2024
- DOI for DNA methylation and stroke prognosis: an epigenome-wide association study
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Part of Nutrition (Burbank, Los Angeles County, Calif.), 2023
- DOI for Plasma phospholipid arachidonic acid in relation to non-alcoholic fatty liver disease: Mendelian randomization study
- Download full text (pdf) of Plasma phospholipid arachidonic acid in relation to non-alcoholic fatty liver disease: Mendelian randomization study
Inverse Association Between Serum 25-Hydroxyvitamin D and Nonalcoholic Fatty Liver Disease
Part of Clinical Gastroenterology and Hepatology, p. 398-4050000, 2023
- DOI for Inverse Association Between Serum 25-Hydroxyvitamin D and Nonalcoholic Fatty Liver Disease
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Part of EBioMedicine, 2023
- DOI for Mendelian randomization and clinical trial evidence supports TYK2 inhibition as a therapeutic target for autoimmune diseases
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Part of EBioMedicine, 2023
- DOI for Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses
- Download full text (pdf) of Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses
Part of Clinical Physiology and Functional Imaging, p. 120-127, 2023
- DOI for A detailed investigation of multiple resting cardiovascular parameters in relation to physical fitness
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Part of Alimentary Pharmacology and Therapeutics, p. 399-408, 2023
- DOI for Antioxidants, minerals and vitamins in relation to Crohn's disease and ulcerative colitis: A Mendelian randomization study
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Federated analyses of multiple data sources in drug safety studies
Part of Pharmacoepidemiology and Drug Safety, p. 279-286, 2023
- DOI for Federated analyses of multiple data sources in drug safety studies
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Part of Acta Paediatrica, p. 1011-1018, 2023
- DOI for Effects of prolonged sitting and physical activity breaks on measures of arterial stiffness and cortisol in adolescents
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Part of Alimentary Pharmacology and Therapeutics, p. 475-485, 2023
Part of Diabetologia, p. 800-812, 2023
- DOI for Causal factors underlying diabetes risk informed by Mendelian randomisation analysis: evidence, opportunities and challenges
- Download full text (pdf) of Causal factors underlying diabetes risk informed by Mendelian randomisation analysis: evidence, opportunities and challenges
Part of American Journal of Gastroenterology, p. 511-522, 2023
- DOI for The Contribution of Genetic Risk and Lifestyle Factors in the Development of Adult-Onset Inflammatory Bowel Disease: A Prospective Cohort Study
- Download full text (pdf) of The Contribution of Genetic Risk and Lifestyle Factors in the Development of Adult-Onset Inflammatory Bowel Disease: A Prospective Cohort Study
Part of Cancer Epidemiology, Biomarkers and Prevention, p. 809-817, 2023
- DOI for Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis
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Physical Activity, Sedentary Behavior, and Type 2 Diabetes: Mendelian Randomization Analysis
Part of Journal of the Endocrine Society, 2023
- DOI for Physical Activity, Sedentary Behavior, and Type 2 Diabetes: Mendelian Randomization Analysis
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Atopic dermatitis and chronic kidney disease: a bidirectional Mendelian randomization study
Part of Frontiers in Medicine, 2023
- DOI for Atopic dermatitis and chronic kidney disease: a bidirectional Mendelian randomization study
- Download full text (pdf) of Atopic dermatitis and chronic kidney disease: a bidirectional Mendelian randomization study
Ultra-processed food intake and incident venous thromboembolism risk: Prospective cohort study
Part of Clinical Nutrition, p. 1268-1275, 2023
- DOI for Ultra-processed food intake and incident venous thromboembolism risk: Prospective cohort study
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Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
Part of Clinical Proteomics, 2023
- DOI for Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
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Part of BMC Medicine, 2023
- DOI for Appraising the causal relationship between plasma caffeine levels and neuropsychiatric disorders through Mendelian randomization
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Part of Cancer Epidemiology, Biomarkers and Prevention, p. 1048-1060, 2023
Part of Diabetes Care, p. 828-835, 2023
Part of British Journal of Obstetrics and Gynecology, p. 891-901, 2023
- DOI for Pre-pregnancy participation and performance in world's largest cross-country ski race as a proxy for physical exercise and fitness, and perinatal outcomes: Prospective registry-based cohort study
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Part of PLOS ONE, 2023
- DOI for Acute effects of nitrate and breakfast on working memory, cerebral blood flow, arterial stiffness, and psychological factors in adolescents: Study protocol for a randomised crossover trial
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Epidemiology of sarcopenia: Prevalence, risk factors, and consequences
Part of Metabolism, 2023
- DOI for Epidemiology of sarcopenia: Prevalence, risk factors, and consequences
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Diet Quality and Risk of Older-onset Crohn's Disease and Ulcerative Colitis
Part of Journal of Crohn's & Colitis, p. 746-753, 2023
Part of Metabolism, 2023
- DOI for Renoprotective effects of genetically proxied fibroblast growth factor 21: Mendelian randomization, proteome-wide and metabolome-wide association study
- Download full text (pdf) of Renoprotective effects of genetically proxied fibroblast growth factor 21: Mendelian randomization, proteome-wide and metabolome-wide association study
Part of Journal of Crohn's & Colitis, p. 777-785, 2023
- DOI for Bidirectional Mendelian Randomisation Analysis Provides Evidence for the Causal Involvement of Dysregulation of CXCL9, CCL11 and CASP8 in the Pathogenesis of Ulcerative Colitis
- Download full text (pdf) of Bidirectional Mendelian Randomisation Analysis Provides Evidence for the Causal Involvement of Dysregulation of CXCL9, CCL11 and CASP8 in the Pathogenesis of Ulcerative Colitis
Intra‐individual stability of longitudinal urinary steroid profiles in Swedish athletes
Part of Drug Testing and Analysis, p. 769-778, 2023
- DOI for Intra‐individual stability of longitudinal urinary steroid profiles in Swedish athletes
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Part of The journals of gerontology. Series A, Biological sciences and medical sciences, 2023
Swedish Snuff (Snus), Cigarette Smoking, and Risk of Type 2 Diabetes
Part of American Journal of Preventive Medicine, p. 60-66, 2023
- DOI for Swedish Snuff (Snus), Cigarette Smoking, and Risk of Type 2 Diabetes
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Part of CELL REPORTS MEDICINE, 2023
- DOI for Plasma proteins and onset of type 2 diabetes and diabetic complications: Proteome-wide Mendelian randomization and colocalization analyses
- Download full text (pdf) of Plasma proteins and onset of type 2 diabetes and diabetic complications: Proteome-wide Mendelian randomization and colocalization analyses
The metabolomic profiling of total fat and fat distribution in a multi-cohort study of women and men
Part of Scientific Reports, 2023
- DOI for The metabolomic profiling of total fat and fat distribution in a multi-cohort study of women and men
- Download full text (pdf) of The metabolomic profiling of total fat and fat distribution in a multi-cohort study of women and men
Part of European Heart Journal - Quality of Care and Clinical Outcomes, 2023
Part of American Journal of Hematology, 2023