Pediatric oncological and neurological research
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By increasing our understanding of the clinical, biological, and psychosocial aspects of childhood neurological diseases and childhood cancer, the research group Pediatric oncological and neurological research works to improve the quality of life for children and adolescents with these diseases and their families.
The research performed within our research group spans from experimental studies using molecular biological techniques to behavioral research aiming to help children and their families better cope with demanding treatments. We collaborate nationally and internationally, both leading and participating in different research projects. We work especially tightly together with research group Pediatric oncology research with a special focus on side effects with whom we have several collaborative projects.
Special resources at UU
Protein beam therapy
The Skandion Clinic in Uppsala started in 2015 and is a national, and even Nordic, resource and entails a significant expansion of the therapeutic arsenal for children with cancer. Protein beam therapy enables the irradiation field to be precisely controlled, thereby limiting damage to nearby healthy tissues. The establishment of Skandion Clinic provides increased possibilities for radiation therapy for younger patients, where treatment is otherwise restrictive due to the risks for serious late complications, particularly in the brain.
Biobanks
There are two biobanks connected to Uppsala with a particular focus on childhood cancer and neuropediatrics: The Nordic biobank for childhood leukemia (Frost main responsible, Palle et al.) and the Swedish childhood tumour biobank (Ljungman clinical leader and chairman of the board). Learn more about both biobanks on the Swedish Childhood Cancer Fund's website (in Swedish only).
Research funders
We would like to warmly thank our funders, collaborators, and all patients and their parents who enable our research work, including for example the Swedish Childhood Cancer Fund, Gillbergska Stiftelsen, Lions Cancerforskningsfond Mellansverige Uppsala-Örebro, Mary Bevés Stiftelse, Insamlingsstiftelsen för Prader-Willi forskning, and Region Uppsala.
Publications
Comparison of high-throughput single-cell RNA-seq methods for ex vivo drug screening
Part of NAR Genomics and Bioinformatics, 2024
- DOI for Comparison of high-throughput single-cell RNA-seq methods for ex vivo drug screening
- Download full text (pdf) of Comparison of high-throughput single-cell RNA-seq methods for ex vivo drug screening
Refining risk prediction in pediatric acute lymphoblastic leukemia through DNA methylation profiling
Part of Clinical Epigenetics, 2024
- DOI for Refining risk prediction in pediatric acute lymphoblastic leukemia through DNA methylation profiling
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Part of JBMR Plus, 2024
- DOI for Demographic and disease-related factors impact bone turnover and vitamin D in children with hemato-oncological diseases
- Download full text (pdf) of Demographic and disease-related factors impact bone turnover and vitamin D in children with hemato-oncological diseases
Part of Pediatric Blood & Cancer, 2024
- DOI for Educational and occupational outcomes in Swedish children treated for sarcomas: A nationwide registry-based study
- Download full text (pdf) of Educational and occupational outcomes in Swedish children treated for sarcomas: A nationwide registry-based study
Part of Children & society, p. 228-244, 2024
- DOI for Exploring young people's experiences of race, gender and socioeconomic status in relation to everyday challenges: A focus group study
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Part of Vaccines, 2023
- DOI for Barriers in the School-Based Pan-Gender HPV Vaccination Program in Sweden: Healthcare Providers' Perspective
- Download full text (pdf) of Barriers in the School-Based Pan-Gender HPV Vaccination Program in Sweden: Healthcare Providers' Perspective
Part of Acta Paediatrica, p. 742-752, 2023
- DOI for Predictive value of Bayley-III Motor Index for later motor difficulties in children born extremely preterm
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Perceptions of health among school-aged children living in socially vulnerable areas in Sweden
Part of Frontiers In Public Health, 2023
- DOI for Perceptions of health among school-aged children living in socially vulnerable areas in Sweden
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Childhood lymphoma treatment impacts educational outcomes: a registry study from Sweden
Part of Journal of cancer survivorship, p. 1072-1081, 2023
- DOI for Childhood lymphoma treatment impacts educational outcomes: a registry study from Sweden
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Part of British Journal of Haematology, p. 384-392, 2023
- DOI for The prognostic impact of IKZF1 deletions and UKALL genetic classifiers in paediatric B-cell precursor acute lymphoblastic leukaemia treated according to NOPHO 2008 protocols
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Characteristics and outcome of primary resistant disease in paediatric acute myeloid leukaemia
Part of British Journal of Haematology, p. 757-765, 2023
- DOI for Characteristics and outcome of primary resistant disease in paediatric acute myeloid leukaemia
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Part of European Journal of Pediatrics, 2023
Part of Journal of Lipid Research, 2023
- DOI for The atypical sphingolipid SPB 18:1(14Z);O2 is a biomarker for DEGS1 related hypomyelinating leukodystrophy
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Part of Nursing Open, p. 630-640, 2023
- DOI for Factors associated with posttraumatic growth among spouses of women diagnosed with gynaecological cancer: A cross-sectional study
- Download full text (pdf) of Factors associated with posttraumatic growth among spouses of women diagnosed with gynaecological cancer: A cross-sectional study
Part of The Pharmacogenomics Journal, p. 105-111, 2023
- DOI for DNA polymerase gamma variants and hepatotoxicity during maintenance therapy of childhood acute lymphoblastic leukemia: is there a causal relationship?
- Download full text (pdf) of DNA polymerase gamma variants and hepatotoxicity during maintenance therapy of childhood acute lymphoblastic leukemia: is there a causal relationship?
Part of Cancers, 2023
- DOI for Simultaneous Ultra-Sensitive Detection of Structural and Single Nucleotide Variants Using Multiplex Droplet Digital PCR in Liquid Biopsies from Children with Medulloblastoma
- Download full text (pdf) of Simultaneous Ultra-Sensitive Detection of Structural and Single Nucleotide Variants Using Multiplex Droplet Digital PCR in Liquid Biopsies from Children with Medulloblastoma
Multimodal classification of molecular subtypes in pediatric acute lymphoblastic leukemia
Part of npj Precision Oncology, 2023
- DOI for Multimodal classification of molecular subtypes in pediatric acute lymphoblastic leukemia
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Part of Cancer Medicine, p. 7459-7469, 2023
- DOI for Occupational outcomes after high-grade or low-grade brain tumors in childhood: A Swedish, nationwide, registry-based study
- Download full text (pdf) of Occupational outcomes after high-grade or low-grade brain tumors in childhood: A Swedish, nationwide, registry-based study
Patterns of smartphone usage associated with depressive symptoms in nursing students
Part of Frontiers in Psychiatry, 2023
- DOI for Patterns of smartphone usage associated with depressive symptoms in nursing students
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Increased MYB alternative promoter usage is associated with relapse in acute lymphoblastic leukemia
Part of Genes, Chromosomes and Cancer, p. 597-606, 2023
- DOI for Increased MYB alternative promoter usage is associated with relapse in acute lymphoblastic leukemia
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Part of Acta Oncologica, p. 1723-1731, 2023
- DOI for Impact of body mass index on outcome and treatment-related toxicity in young adults with acute lymphoblastic leukemia
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Part of HemaSphere, 2023
- DOI for Genetic Subtypes and Outcome of Patients Aged 1 to 45 Years Old With Acute Lymphoblastic Leukemia in the NOPHO ALL2008 Trial
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Early disc degeneration in radiotherapy-treated childhood brain tumor survivors
Part of BMC Musculoskeletal Disorders, 2023
- DOI for Early disc degeneration in radiotherapy-treated childhood brain tumor survivors
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Parental experiences of the informed consent process in randomized clinical trials-A Nordic study
Part of Pediatric Blood & Cancer, 2023
- DOI for Parental experiences of the informed consent process in randomized clinical trials-A Nordic study
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Part of Pediatric Transplantation, 2023
- DOI for A retrospective case-control study of gastrostomy use in children undergoing hematopoietic cell transplantation
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Part of Child's Nervous System, p. 1479-1485, 2022
Part of Supportive Care in Cancer, p. 1901-1902, 2022
Part of Pediatric Blood & Cancer, 2022
- DOI for Does minimal central nervous system involvement in childhood acute lymphoblastic leukemia increase the risk for central nervous system toxicity?
- Download full text (pdf) of Does minimal central nervous system involvement in childhood acute lymphoblastic leukemia increase the risk for central nervous system toxicity?
COVID-19 seroprevalence and clinical picture in Swedish pediatric oncology and hematology patients
Part of Pediatric Blood & Cancer, 2022
- DOI for COVID-19 seroprevalence and clinical picture in Swedish pediatric oncology and hematology patients
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Part of Leukemia and Lymphoma, p. 2311-2320, 2022
- DOI for Familial platelet disorder due to germline exonic deletions in RUNX1: a diagnostic challenge with distinct alterations of the transcript isoform equilibrium
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High need for intensive care in paediatric acute myeloid leukaemia: A population-based study
Part of Acta Paediatrica, p. 2235-2241, 2022
- DOI for High need for intensive care in paediatric acute myeloid leukaemia: A population-based study
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Part of Pediatric Blood & Cancer, 2022
- DOI for Prospective registration of symptoms and times to diagnosis in children and adolescents with central nervous system tumors: A study of the Swedish Childhood Cancer Registry
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Part of Expert Review of Anticancer Therapy, p. 1183-1196, 2022
Part of PLOS ONE, 2022
- DOI for Pre- and postdiagnosis growth failure, adult short stature, and untreated growth hormone deficiency in radiotherapy-treated long-term survivors of childhood brain tumor
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Part of British Journal of Haematology, p. 1032-1040, 2022
- DOI for Quality of life in mothers and fathers of children treated for acute lymphoblastic leukaemia in Sweden, Finland and Denmark
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Part of Belitung Nursing Journal, p. 213-221, 2022
- DOI for Effectiveness of art-based distraction in reducing pain and anxiety of hospitalized children during cannulation procedure: A randomized controlled trial
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Part of Complementary Therapies in Clinical Practice, 2022
Obesity as a predictor of treatment-related toxicity in children with acute lymphoblastic leukaemia
Part of British Journal of Haematology, p. 1239-1247, 2022
- DOI for Obesity as a predictor of treatment-related toxicity in children with acute lymphoblastic leukaemia
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The human cathelicidin hCAP-18 in serum of children with haemato-oncological diseases
Part of British Journal of Haematology, p. 1023-1031, 2022
- DOI for The human cathelicidin hCAP-18 in serum of children with haemato-oncological diseases
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Part of International Journal of Cancer, p. 406-419, 2022
A somatic UBA2 variant preceded ETV6-RUNX1 in the concordant BCP-ALL of monozygotic twins
Part of Blood Advances, p. 2275-2289, 2022
Part of Blood, p. 3159-3165, 2022
Part of Supportive Care in Cancer, p. 127-133, 2022
- DOI for Reduced dose folinic acid rescue after rapid high-dose methotrexate clearance is not associated with increased toxicity in a pediatric cohort
- Download full text (pdf) of Reduced dose folinic acid rescue after rapid high-dose methotrexate clearance is not associated with increased toxicity in a pediatric cohort
Part of Frontiers in Oncology, 2022
- DOI for Patient-Specific Assays Based on Whole-Genome Sequencing Data to Measure Residual Disease in Children With Acute Lymphoblastic Leukemia: A Proof of Concept Study
- Download full text (pdf) of Patient-Specific Assays Based on Whole-Genome Sequencing Data to Measure Residual Disease in Children With Acute Lymphoblastic Leukemia: A Proof of Concept Study
Part of Pediatric Rheumatology, 2022
- DOI for Severe Raynaud's phenomenon from ethosuximide raised concern over possible onset of systemic vasculitis: a case report
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Part of Blood Advances, p. 152-164, 2022
- DOI for Transcriptomic analysis reveals proinflammatory signatures associated with acute myeloid leukemia progression
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Part of Cancer Chemotherapy and Pharmacology, p. 911-917, 2021
Part of Pediatric Critical Care Medicine, p. 1050-1060, 2021
Part of British Journal of Haematology, p. 119-122, 2021
Part of Haematologica, p. 2318-2328, 2020
- DOI for Acute central nervous system toxicity during treatment of pediatric acute lymphoblastic leukemia: phenotypes, risk factors and genotypes
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