Molekyär avbildning och medicinsk fysik

Gruppens forskning täcker hela perspektivet från substansscreening, via radiokemi och preklinisk validering, till klinisk implementering.

Forskning inom nuklearmedicin och PET är främst inriktad på utveckling av nya PET-tracers och kliniska PET-metoder, för att möta kliniska krav och underlätta klinisk forskning, samt på diagnos och behandling av neuroendokrina tumörer.

Gruppens forskning täcker hela perspektivet från substansscreening, via radiokemi och preklinisk validering, till klinisk implementering ("bench to bedside"). Deras kliniska forskning fokuserar på användningen av PET för att skapa förutsättningar för individanpassad medicin, till exempel i samband med molekylär strålbehandling och andra kostsamma cancerterapier. Dessutom syftar deras forskning till att öka förståelsen för molekylära processer i samband med olika sjukdomar, t.ex. utvecklingen av multimodal avbildning med PET-MRI i samband med metaboliska sjukdomar och cancer. För att kunna erbjuda en komplett plattform för användning av PET och PET-MRI inom klinisk forskning och läkemedelsutveckling, har PET-gruppen vid Uppsala universitet och Akademiska sjukhuset en hög kompetens inom alla aspekter av PET-metodik: kemi, fysik, dataanalys, etc.

Samarbete

Forskningen inom gruppen för nuklearmedicin och PET vid institutionen för kirurgiska vetenskaper utförs i nära samarbete med PET-MRI-gruppen, den prekliniska PET-plattformen vid institutionen för läkemedelskemi, sektionen för biomedicinsk strålningsvetenskap vid institutionen för genetik och patologi, PET-centrum vid Akademiska sjukhuset i Uppsala samt ett antal kliniska forskargrupper vid Uppsala universitet och Akademiska sjukhuset i Uppsala.

Porträttfoto av Mark Lubberink

Mark Lubberink

Gruppmedlemmar

Forskningsledare: Jens Sörensen, Mark Lubberink

Se enhetens sida i personal- och organisationskatalogen.

Publikationer

Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications

Engström, G.; Lampa, Erik; Dekkers, Koen; Lin, Yi-Ting et al.

Ingår i Eur J Epidemiol, 2024
- DOI för Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications
Comparison of quantitative [11C]PE2I brain PET studies between an integrated PET/MR and a stand-alone PET system

Sousa, Joao M.; Appel, Lieuwe; Engstrom, Mathias; Nyholm, Dag et al.

Ingår i Physica medica (Testo stampato), 2024
- DOI för Comparison of quantitative [11C]PE2I brain PET studies between an integrated PET/MR and a stand-alone PET system
- Ladda ner fulltext (pdf) av Comparison of quantitative [11C]PE2I brain PET studies between an integrated PET/MR and a stand-alone PET system
Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes.

Vyakaranam, Achyut Ram; Mahamed, Maryama M; Hellman, Per; Eriksson, Olof et al.

Ingår i Diabetologia, s. 199-208, 2024
- DOI för Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes.
Use and perceived utility of [¹⁸ F]FDG PET/CT in neuroendocrine neoplasms: A consensus report from the European Neuroendocrine Tumor Society (ENETS) Advisory Board Meeting 2022.

Ambrosini, Valentina; Caplin, Martyn; Castaño, Justo P; Christ, Emanuel et al.

Ingår i Journal of neuroendocrinology, 2024
- DOI för Use and perceived utility of [¹⁸ F]FDG PET/CT in neuroendocrine neoplasms: A consensus report from the European Neuroendocrine Tumor Society (ENETS) Advisory Board Meeting 2022.
A systematic review for the evidence of recommendations and guidelines in hybrid nuclear cardiovascular imaging.

Besson, Florent L; Treglia, Giorgio; Bucerius, Jan; Anagnostopoulos, Constantinos et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2024
- DOI för A systematic review for the evidence of recommendations and guidelines in hybrid nuclear cardiovascular imaging.
Outcome prediction by myocardial external efficiency from ¹¹C-acetate positron emission tomography in cardiac amyloidosis

Rosengren, Sara; Skibsted Clemmensen, Tor; Hvitfeldt Poulsen, Steen; Tolbod, Lars et al.

Ingår i ESC Heart Failure, s. 44-53, 2024
- DOI för Outcome prediction by myocardial external efficiency from ¹¹C-acetate positron emission tomography in cardiac amyloidosis
- Ladda ner fulltext (pdf) av Outcome prediction by myocardial external efficiency from ¹¹C-acetate positron emission tomography in cardiac amyloidosis
Massive Chylous Ascites in a 9-Year-Old Girl with Malrotation-A Case Report

Winberg, Hans; Gerwins, Pär; Hagelsteen, Kristine

Ingår i EUROPEAN JOURNAL OF PEDIATRIC SURGERY REPORTS, 2024
- DOI för Massive Chylous Ascites in a 9-Year-Old Girl with Malrotation-A Case Report
- Ladda ner fulltext (pdf) av Massive Chylous Ascites in a 9-Year-Old Girl with Malrotation-A Case Report
Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells

Kopsida, Maria; Clavero, Ada Lerma; Khaled, Jaafar; Balgoma, David et al.

Ingår i Molecular Metabolism, 2024
- DOI för Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells
- Ladda ner fulltext (pdf) av Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells
Dual-Layer computed tomography of the brain: May virtually monoenergetic images provide better diagnosis?

Ghalamkari, Odett

2024
Acute and long-term renal effects after iodine contrast media-enhanced computerised tomography in the critically ill-a retrospective bi-centre cohort study.

Berglund, Felix; Eilertz, Ebba; Nimmersjö, Fredrik; Wolf, Adam et al.

Ingår i European Radiology, s. 1736-1745, 2024
- DOI för Acute and long-term renal effects after iodine contrast media-enhanced computerised tomography in the critically ill-a retrospective bi-centre cohort study.
Rationale and design of the RAPID-WATER-FLOW trial: Radiolabeled perfusion to identify coronary artery disease using water to evaluate responses of myocardial FLOW.

Di Carli, Marcelo F; Gormsen, Lars C; Chareonthaitawee, Panithaya; Johnson, Geoffrey B et al.

Ingår i Journal of Nuclear Cardiology, s. 101779, 2024
- DOI för Rationale and design of the RAPID-WATER-FLOW trial: Radiolabeled perfusion to identify coronary artery disease using water to evaluate responses of myocardial FLOW.
Changes in tumor-to-blood ratio as a prognostic marker for progression-free survival and overall survival in neuroendocrine tumor patients undergoing PRRT.

Weber, Manuel; Pettersson, Olof; Seifert, Robert; Schaarschmidt, Benedikt M et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 841-851, 2024
- DOI för Changes in tumor-to-blood ratio as a prognostic marker for progression-free survival and overall survival in neuroendocrine tumor patients undergoing PRRT.
Impact of simulated reduced injected dose on the assessment of amyloid PET scans.

Young, Peter; Heeman, Fiona; Axelsson, Jan; Collij, Lyduine E et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 734-748, 2024
- DOI för Impact of simulated reduced injected dose on the assessment of amyloid PET scans.
Evaluation of Diffusion Tensor Imaging Analysis Along the Perivascular Space as a Marker of the Glymphatic System.

Haller, Sven; Moy, Linda; Anzai, Yoshimi

Ingår i Radiology, 2024
- DOI för Evaluation of Diffusion Tensor Imaging Analysis Along the Perivascular Space as a Marker of the Glymphatic System.
Functional MRI Neurofeedback Outperforms Cognitive Behavioral Therapy for Reducing Tinnitus Distress: A Prospective Randomized Clinical Trial.

Gninenko, Nicolas; Trznadel, Stéphanie; Daskalou, Dimitrios; Gramatica, Luca et al.

Ingår i Radiology, 2024
- DOI för Functional MRI Neurofeedback Outperforms Cognitive Behavioral Therapy for Reducing Tinnitus Distress: A Prospective Randomized Clinical Trial.
Quantitative and qualitative comparison of Rubidium-82 and Oxygen-15 water cardiac PET.

Hoff, Camilla Molich; Sørensen, Jens; Kero, Tanja; Bouchelouche, Kirsten et al.

Ingår i Journal of Nuclear Cardiology, s. 101796, 2024
- DOI för Quantitative and qualitative comparison of Rubidium-82 and Oxygen-15 water cardiac PET.
The Evolutionary History of Metastatic Pancreatic Neuroendocrine Tumours Reveals a Therapy Driven Route to High-Grade Transformation.

Backman, Samuel; Botling, Johan; Nord, Helena; Ghosal, Suman et al.

Ingår i medRxiv : the preprint server for health sciences, 2024
- DOI för The Evolutionary History of Metastatic Pancreatic Neuroendocrine Tumours Reveals a Therapy Driven Route to High-Grade Transformation.
Multi-level Residual Dual Attention Network for Major Cerebral Arteries Segmentation in MRA towards Diagnosis of Cerebrovascular Disorders

Pal, Subhash Chandra; Toumpanakis, Dimitrios; Wikström, Johan; Ahuja, Chirag Kamal et al.

Ingår i IEEE Transactions on Nanobioscience, s. 167-175, 2024
- DOI för Multi-level Residual Dual Attention Network for Major Cerebral Arteries Segmentation in MRA towards Diagnosis of Cerebrovascular Disorders
ASE-Net for Segmentation of Post-operative Glioblastoma and Patient-specific Fine-tuning for Segmentation Refinement of Follow-up MRI Scans

Kundu, Swagata; Banerjee, Subhashis; Breznik, Eva; Toumpanakis, Dimitrios et al.

Ingår i SN computer science, 2024
- DOI för ASE-Net for Segmentation of Post-operative Glioblastoma and Patient-specific Fine-tuning for Segmentation Refinement of Follow-up MRI Scans
Time-Activity data fitting in molecular Radiotherapy: Methodology and pitfalls

Ivashchenko, Oleksandra V.; O'Doherty, Jim; Hardiansyah, Deni; Cremonesi, Marta et al.

Ingår i Physica medica (Testo stampato), 2024
- DOI för Time-Activity data fitting in molecular Radiotherapy: Methodology and pitfalls
- Ladda ner fulltext (pdf) av Time-Activity data fitting in molecular Radiotherapy: Methodology and pitfalls
Hypoalbuminemia, but not derived neutrophil to lymphocyte ratio (dNLR), predicts overall survival in neuroendocrine tumours undergoing peptide receptor radionuclide therapy: A retrospective, cohort study of 557 patients

Papantoniou, Dimitrios; Fröss-Baron, Katarzyna; Garske Roman, Ulrike; Sundin, Anders et al.

Ingår i Journal of neuroendocrinology, 2024
- DOI för Hypoalbuminemia, but not derived neutrophil to lymphocyte ratio (dNLR), predicts overall survival in neuroendocrine tumours undergoing peptide receptor radionuclide therapy: A retrospective, cohort study of 557 patients
- Ladda ner fulltext (pdf) av Hypoalbuminemia, but not derived neutrophil to lymphocyte ratio (dNLR), predicts overall survival in neuroendocrine tumours undergoing peptide receptor radionuclide therapy: A retrospective, cohort study of 557 patients
Effect of MRI acquisition parameters on accuracy and precision of phase-contrast measurements in a small-lumen vessel phantom

Correia de Verdier, Maria; Berglund, Johan; Wikström, Johan

Ingår i European radiology experimental, 2024
- DOI för Effect of MRI acquisition parameters on accuracy and precision of phase-contrast measurements in a small-lumen vessel phantom
- Ladda ner fulltext (pdf) av Effect of MRI acquisition parameters on accuracy and precision of phase-contrast measurements in a small-lumen vessel phantom
Microwave ablation of 105 T1 renal tumors: technique efficacy with a mean follow-up of two years

Acosta Ruiz, Vanessa; Dahlman, Pär; Brekkan, Einar; Lönnemark, Maria et al.

Ingår i Acta Radiologica, s. 294-301, 2024
- DOI för Microwave ablation of 105 T1 renal tumors: technique efficacy with a mean follow-up of two years
- Ladda ner fulltext (pdf) av Microwave ablation of 105 T1 renal tumors: technique efficacy with a mean follow-up of two years
Introduction of a fatty acid chain modification to prolong circulatory half-life of a radioligand towards glucose-dependent insulinotropic polypeptide receptor

Khalil, Amina; Hakhverdyan, Sona; Cheung, Pierre; Bossart, Martin et al.

Ingår i Nuclear Medicine and Biology, 2024
- DOI för Introduction of a fatty acid chain modification to prolong circulatory half-life of a radioligand towards glucose-dependent insulinotropic polypeptide receptor
- Ladda ner fulltext (pdf) av Introduction of a fatty acid chain modification to prolong circulatory half-life of a radioligand towards glucose-dependent insulinotropic polypeptide receptor
Gadoliniumretention, dess inverkan på människokroppen samt vilka förebyggande åtgärder röntgensjuksköterskan kan behöva implementera: En litteraturstudie

Ahlkvist, Malin; Lidell, Tilda

2024
- Ladda ner fulltext (pdf) av Gadoliniumretention, dess inverkan på människokroppen samt vilka förebyggande åtgärder röntgensjuksköterskan kan behöva implementera: En litteraturstudie
Deep learning segmentation of low-resolution images for prostate magnetic resonance-guided radiotherpy

Fransson, Samuel; Tilly, David; Strand, Robin

2024
Absolute and relative GFR and contrast medium dose/GFR ratio: cornerstones when predicting the risk of acute kidney injury.

Nyman, Ulf; Leander, Peter; Liss, Per; Sterner, Gunnar et al.

Ingår i European Radiology, s. 612-621, 2024
- DOI för Absolute and relative GFR and contrast medium dose/GFR ratio: cornerstones when predicting the risk of acute kidney injury.
Patienters upplevelse av information i samband med en ¹⁸F-FDG PET/DT-undersökning: En kvantitativ enkätstudie

Arcos Qvarnström, Ronja; Bonde Kalén, Matilda

2024
- Ladda ner fulltext (pdf) av Patienters upplevelse av information i samband med en ¹⁸F-FDG PET/DT-undersökning: En kvantitativ enkätstudie
Overfeeding polyunsaturated fat compared to saturated fat does not differentially influence lean tissue accumulation in overweight individuals: a randomized controlled trial.

Rosqvist, Fredrik; Cedernaes, Jonathan; Mora, Andrés Martínez; Fridén, Michael et al.

Ingår i American Journal of Clinical Nutrition, 2024
- DOI för Overfeeding polyunsaturated fat compared to saturated fat does not differentially influence lean tissue accumulation in overweight individuals: a randomized controlled trial.
Analysis of plasma metabolomes from 11 309 subjects in five population-based cohorts.

Ghosh, Nilanjana; Lejonberg, Carl; Czuba, Tomasz; Dekkers, Koen et al.

Ingår i Scientific Reports, s. 8933, 2024
- DOI för Analysis of plasma metabolomes from 11 309 subjects in five population-based cohorts.
Optimizing diagnostics and follow-up of patients with ureterolithiasis

Sahlén, Klara

2024
- Ladda ner fulltext (pdf) av Optimizing diagnostics and follow-up of patients with ureterolithiasis
Trends in incidence and treatments of spontaneous subarachnoid hemorrhage: a 10 year hospital based study

Ronne-Engström, Elisabeth; Borota, Ljubisa; Lenell, Samuel; Lewén, Anders et al.

Ingår i Acta Neurochirurgica, 2024
- DOI för Trends in incidence and treatments of spontaneous subarachnoid hemorrhage: a 10 year hospital based study
- Ladda ner fulltext (pdf) av Trends in incidence and treatments of spontaneous subarachnoid hemorrhage: a 10 year hospital based study
Can AI Predict the Need for Surgery in Traumatic Brain Injury?

Haller, Sven

Ingår i Radiology: Artificial Intelligence, 2024
- DOI för Can AI Predict the Need for Surgery in Traumatic Brain Injury?
Comparing multi-image and image augmentation strategies for deep learning-based prostate segmentation

Fransson, Samuel

Ingår i Physics and Imaging in Radiation Oncology, 2024
- DOI för Comparing multi-image and image augmentation strategies for deep learning-based prostate segmentation
- Ladda ner fulltext (pdf) av Comparing multi-image and image augmentation strategies for deep learning-based prostate segmentation
Application of PET/MRI in Gynecologic Malignancies

Ebrahimi, Sheida; Lundström, Elin; Batasin, Summer J.; Hedlund, Elisabeth et al.

Ingår i Cancers, 2024
- DOI för Application of PET/MRI in Gynecologic Malignancies
- Ladda ner fulltext (pdf) av Application of PET/MRI in Gynecologic Malignancies
Machine Learning in Magnetic Resonance-Guided Adaptive Radiotherapy

Fransson, Samuel

2024
- Ladda ner fulltext (pdf) av Machine Learning in Magnetic Resonance-Guided Adaptive Radiotherapy
Voxel-wise body composition analysis using image registration of a three-slice CT imaging protocol: methodology and proof-of-concept studies

Ahmad, Nouman; Dahlberg, Hugo; Jönsson, Hanna; Tarai, Sambit et al.

Ingår i Biomedical engineering online, 2024
- DOI för Voxel-wise body composition analysis using image registration of a three-slice CT imaging protocol: methodology and proof-of-concept studies
- Ladda ner fulltext (pdf) av Voxel-wise body composition analysis using image registration of a three-slice CT imaging protocol: methodology and proof-of-concept studies
Volumetric MRI with sparse sampling for MR-guided 3D motion tracking via sparse prior-augmented implicit neural representation learning

Liu, Lianli; Shen, Liyue; Johansson, Adam; Balter, James M. et al.

Ingår i Medical physics (Lancaster), s. 2526-2537, 2024
- DOI för Volumetric MRI with sparse sampling for MR-guided 3D motion tracking via sparse prior-augmented implicit neural representation learning
Patienters upplevelser kring information inför en ¹⁸F-FDG- PET/DT-undersökning: En enkätstudie

Carlsson, Elina; Chen Sagrén, Maja

2024
- Ladda ner fulltext (pdf) av Patienters upplevelser kring information inför en ¹⁸F-FDG- PET/DT-undersökning: En enkätstudie
Improving Semi-Automated Segmentation Using Self-Supervised Learning

Blomlöf, Alexander

2024
- Ladda ner fulltext (pdf) av Improving Semi-Automated Segmentation Using Self-Supervised Learning
A scoping review of person-centred care strategies used in diagnostic Nuclear Medicine

Champendal, M.; Grima, K. Borg; Costa, P.; Andersson, Camilla et al.

Ingår i Radiography, s. 448-456, 2024
- DOI för A scoping review of person-centred care strategies used in diagnostic Nuclear Medicine
Streamlining neuroradiology workflow with AI for improved cerebrovascular structure monitoring

Banerjee, Subhashis; Nysjö, Fredrik; Toumpanakis, Dimitrios; Dhara, Ashis Kumar et al.

Ingår i Scientific Reports, 2024
- DOI för Streamlining neuroradiology workflow with AI for improved cerebrovascular structure monitoring
- Ladda ner fulltext (pdf) av Streamlining neuroradiology workflow with AI for improved cerebrovascular structure monitoring
Pupil dilation during negative prediction errors is related to brain choline concentration and depressive symptoms in adolescents

Guath, Mona; Kleberg, Johan Lundin; Weis, Jan; Widegren, Ebba et al.

Ingår i Behavioural Brain Research, 2023
- DOI för Pupil dilation during negative prediction errors is related to brain choline concentration and depressive symptoms in adolescents
- Ladda ner fulltext (pdf) av Pupil dilation during negative prediction errors is related to brain choline concentration and depressive symptoms in adolescents
First-in-human evaluation of [¹⁸F]CETO: a novel tracer for adrenocortical tumours

Silins, Isabella; Sundin, Anders; Lubberink, Mark; O'Sullivan, Lleah et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 398-409, 2023
- DOI för First-in-human evaluation of [¹⁸F]CETO: a novel tracer for adrenocortical tumours
- Ladda ner fulltext (pdf) av First-in-human evaluation of [¹⁸F]CETO: a novel tracer for adrenocortical tumours
Monitoring of neuroendocrine tumor patients undergoing systemic therapies

Pettersson, Olof

2023
- Ladda ner fulltext (pdf) av Monitoring of neuroendocrine tumor patients undergoing systemic therapies
Interleukin-33 inhibits glucose uptake in human adipocytes and its expression in adipose tissue is elevated in insulin resistance and type 2 diabetes

Pereira, Maria J.; Azim, Ayesha; Hetty, Susanne; Jui Nandi, Bipasha et al.

Ingår i Cytokine, 2023
- DOI för Interleukin-33 inhibits glucose uptake in human adipocytes and its expression in adipose tissue is elevated in insulin resistance and type 2 diabetes
- Ladda ner fulltext (pdf) av Interleukin-33 inhibits glucose uptake in human adipocytes and its expression in adipose tissue is elevated in insulin resistance and type 2 diabetes
Peptide Receptor Radionuclide Therapy in Neuroendocrine Neoplasms: Aspects of tumour characteristics, receptor recycling and peptide mass

Jahn, Ulrika

2023
- Ladda ner fulltext (pdf) av Peptide Receptor Radionuclide Therapy in Neuroendocrine Neoplasms: Aspects of tumour characteristics, receptor recycling and peptide mass
Cancer imaging and image analysis methods in whole-body MRI and PET/MRI

Sjöholm, Therese

2023
- Ladda ner fulltext (pdf) av Cancer imaging and image analysis methods in whole-body MRI and PET/MRI
Introducing spatial context in patch-based deep learning for semantic segmentation in whole body MRI

Breznik, Eva; Kullberg, Joel; Ahlström, Håkan; Strand, Robin

Ingår i Proceedings of the 22nd Scandinavian conference on image analysis (SCIA), 2023
The Use of Diffusion Weighted Imaging and Intravoxel Incoherent Motion to Assess Edema and Perfusion in Abdominal Organs during Endotoxemia

Marchesi, Silvia; Lundström, Elin; Ahlström, Håkan; Lipcsey, Miklós

Ingår i MAGNETOCHEMISTRY, 2023
- DOI för The Use of Diffusion Weighted Imaging and Intravoxel Incoherent Motion to Assess Edema and Perfusion in Abdominal Organs during Endotoxemia
- Ladda ner fulltext (pdf) av The Use of Diffusion Weighted Imaging and Intravoxel Incoherent Motion to Assess Edema and Perfusion in Abdominal Organs during Endotoxemia