Öron-, näs- och halskirurgi
![Foto på Linda Skoglund](/images/18.d9b4e4f18e18a99a2c47b18/1710938074532/%C3%96NH%20Linda%20Marklund%20005-800px.1932x868px.jpg)
Forskargruppsledare Linda Marklund. Foto: Mikael Wallerstedt
Huvud-halsområdet är ett av kroppens mest komplexa områden när det kommer till anatomi och funktion.
Huvud-halsområdet omfattar många vitala strukturer som påverkar vår livskvalitet såsom sinnesorgan för hörsel, balans, lukt och smak, och andning, röst, svälj- och tuggfunktioner samt även ansiktets mimik och sensorisk. Halsen inbegriper även rösten som är ett viktigt instrument i den mänskliga kommunikationen. Dessa funktioner kan påverkas av såväl sjukdomar samt den behandling som ges.
Forskningen inom detta område inbegriper såväl grundforskning som strävar till ökad förståelse för organs anatomi och funktion som kliniska behandlingsstudier. Det grundläggande syftet är att öka kunskapen om sjukdomar och deras förlopp för att kunna förbättra behandlingen för den enskilde patienten.
På dessa sidor presenteras en överblick av de olika forskningsområden och projekt som pågår just nu.
Pågående forskning:
Publikationer
Ingår i International Journal of Pediatric Otorhinolaryngology, 2024
- DOI för Estimated prevalence of permanent hearing loss among newborns and 6-year-olds: An evaluation of the three auditory screenings in Uppsala
- Ladda ner fulltext (pdf) av Estimated prevalence of permanent hearing loss among newborns and 6-year-olds: An evaluation of the three auditory screenings in Uppsala
Ingår i Supportive Care in Cancer, 2024
- DOI för Mapping the impact of malnutrition as defined by the Global Leadership Initiative on Malnutrition and nutrition impact symptoms on the possibility of returning to work after treatment for head and neck cancer
- Ladda ner fulltext (pdf) av Mapping the impact of malnutrition as defined by the Global Leadership Initiative on Malnutrition and nutrition impact symptoms on the possibility of returning to work after treatment for head and neck cancer
Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists
Ingår i Nature Communications, 2024
- DOI för Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists
- Ladda ner fulltext (pdf) av Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists
Vestibular schwannoma: Clinical, Epidemiological and Biochemical perspectives
2024
Inner ear proteomics and barriers: Clinical and experimental findings
2024
Ingår i Plastic and reconstructive surgery (1963), 2024
Ingår i Oral Oncology, 2024
- DOI för Human papillomavirus (HPV) load is higher in HPVDNA/p16 positive than in HPVDNA positive/p16 negative oropharyngeal squamous cell carcinoma but does not differ significantly between various subsites or correlate to survival
- Ladda ner fulltext (pdf) av Human papillomavirus (HPV) load is higher in HPVDNA/p16 positive than in HPVDNA positive/p16 negative oropharyngeal squamous cell carcinoma but does not differ significantly between various subsites or correlate to survival
Systemic inflammation and prognostic markers in patients with head and neck cancer
2024
Immuno-surveillance and protection of the human cochlea
Ingår i Frontiers in Neurology, 2024
- DOI för Immuno-surveillance and protection of the human cochlea
- Ladda ner fulltext (pdf) av Immuno-surveillance and protection of the human cochlea
Ingår i PLOS ONE, 2024
- DOI för Six-month mortality has decreased for patients with curative treatment intent for head and neck cancer in Sweden
- Ladda ner fulltext (pdf) av Six-month mortality has decreased for patients with curative treatment intent for head and neck cancer in Sweden
Ingår i iScience, 2024
- DOI för MDM2/MDMX inhibition by Sulanemadlin synergizes with anti-Programmed Death 1 immunotherapy in wild-type p53 tumors
- Ladda ner fulltext (pdf) av MDM2/MDMX inhibition by Sulanemadlin synergizes with anti-Programmed Death 1 immunotherapy in wild-type p53 tumors
Ingår i BMC Cancer, 2024
- DOI för The effect of internet-administered support (carer eSupport) on preparedness for caregiving in informal caregivers of patients with head and neck cancer compared with support as usual: a study protocol for a randomized controlled trial
- Ladda ner fulltext (pdf) av The effect of internet-administered support (carer eSupport) on preparedness for caregiving in informal caregivers of patients with head and neck cancer compared with support as usual: a study protocol for a randomized controlled trial
Fall-related injury among patients with vestibular schwannoma
Ingår i PLOS ONE, 2024
- DOI för Fall-related injury among patients with vestibular schwannoma
- Ladda ner fulltext (pdf) av Fall-related injury among patients with vestibular schwannoma
Accuracy of p16 IHC in Classifying HPV-Driven OPSCC in Different Populations
Ingår i Cancers, 2023
- DOI för Accuracy of p16 IHC in Classifying HPV-Driven OPSCC in Different Populations
- Ladda ner fulltext (pdf) av Accuracy of p16 IHC in Classifying HPV-Driven OPSCC in Different Populations
Ingår i International Journal of Molecular Sciences, 2023
- DOI för Loco-Regional Control and Sustained Difference in Serum Immune Protein Expression in Patients Treated for p16-Positive and p16-Negative Head and Neck Squamous Cell Carcinoma
- Ladda ner fulltext (pdf) av Loco-Regional Control and Sustained Difference in Serum Immune Protein Expression in Patients Treated for p16-Positive and p16-Negative Head and Neck Squamous Cell Carcinoma
Do Patients Aged 85 Years and above Benefit from Their Cochlear Implants?
Ingår i Audiology Research, s. 96-106, 2023
- DOI för Do Patients Aged 85 Years and above Benefit from Their Cochlear Implants?
- Ladda ner fulltext (pdf) av Do Patients Aged 85 Years and above Benefit from Their Cochlear Implants?
Ingår i Frontiers in Cell and Developmental Biology, 2023
- DOI för The ultrastructure of a stria vascularis in the auditory organ of the cuban crocodile (Crocodylus rhombifer)
- Ladda ner fulltext (pdf) av The ultrastructure of a stria vascularis in the auditory organ of the cuban crocodile (Crocodylus rhombifer)
Ingår i The Lancet Oncology, s. 239-251, 2023
- DOI för Prognostic implications of p16 and HPV discordance in oropharyngeal cancer (HNCIG-EPIC-OPC): a multicentre, multinational, individual patient data analysis
- Ladda ner fulltext (pdf) av Prognostic implications of p16 and HPV discordance in oropharyngeal cancer (HNCIG-EPIC-OPC): a multicentre, multinational, individual patient data analysis
Factors that affect quality of life for older people with head and neck cancer: A systematic review
Ingår i European Journal of Oncology Nursing, 2023
- DOI för Factors that affect quality of life for older people with head and neck cancer: A systematic review
- Ladda ner fulltext (pdf) av Factors that affect quality of life for older people with head and neck cancer: A systematic review
Ingår i Scientific Reports, 2023
- DOI för Transcriptomics unravels molecular changes associated with cilia and COVID-19 in chronic rhinosinusitis with nasal polyps
- Ladda ner fulltext (pdf) av Transcriptomics unravels molecular changes associated with cilia and COVID-19 in chronic rhinosinusitis with nasal polyps
Intrasellar Pressure is Related to Endocrine Disturbances in Patients with Pituitary Tumors
Ingår i World Neurosurgery, 2023
- DOI för Intrasellar Pressure is Related to Endocrine Disturbances in Patients with Pituitary Tumors
- Ladda ner fulltext (pdf) av Intrasellar Pressure is Related to Endocrine Disturbances in Patients with Pituitary Tumors
Ingår i Journal of Clinical Sleep Medicine (JCSM), s. 573-579, 2023
Ingår i Oral Oncology, 2023
Ingår i JAMA Otolaryngology - Head and Neck Surgery, s. 390-396, 2023
- DOI för The Risk of Cholesteatoma in Individuals With First-degree Relatives Surgically Treated for the Disease
- Ladda ner fulltext (pdf) av The Risk of Cholesteatoma in Individuals With First-degree Relatives Surgically Treated for the Disease
Regulatory B cells producing IL-10 are increased in human tumor draining lymph nodes
Ingår i International Journal of Cancer, s. 854-866, 2023
- DOI för Regulatory B cells producing IL-10 are increased in human tumor draining lymph nodes
- Ladda ner fulltext (pdf) av Regulatory B cells producing IL-10 are increased in human tumor draining lymph nodes
Ingår i Scandinavian Journal of Medicine and Science in Sports, s. 1509-1518, 2023
- DOI för A longitudinal study of exercise-induced bronchoconstriction and laryngeal obstruction in high school athletes
- Ladda ner fulltext (pdf) av A longitudinal study of exercise-induced bronchoconstriction and laryngeal obstruction in high school athletes
Ingår i European Journal of Oncology Nursing, 2023
- DOI för Perceptions of life and experiences of health care support among individuals one year after head and neck cancer treatment-An interview study
- Ladda ner fulltext (pdf) av Perceptions of life and experiences of health care support among individuals one year after head and neck cancer treatment-An interview study
Ingår i Nature Communications, 2023
Ingår i Austin Journal of Dentistry, s. 1174-1174, 2023
Ingår i Cancers, s. 4705-4705, 2023
- DOI för Predicting Return to Work after Head and Neck Cancer Treatment Is Challenging Due to Factors That Affect Work Ability
- Ladda ner fulltext (pdf) av Predicting Return to Work after Head and Neck Cancer Treatment Is Challenging Due to Factors That Affect Work Ability
Ingår i Scientific Reports, 2023
- DOI för Combination therapy of tyrosine kinase inhibitor sorafenib with the HSP90 inhibitor onalespib as a novel treatment regimen for thyroid cancer
- Ladda ner fulltext (pdf) av Combination therapy of tyrosine kinase inhibitor sorafenib with the HSP90 inhibitor onalespib as a novel treatment regimen for thyroid cancer
Ingår i Heliyon, 2023
- DOI för Utilizing CD44v6 and V600EBRAF-mutation for in vitro targeted combination therapy of thyroid carcinomas
- Ladda ner fulltext (pdf) av Utilizing CD44v6 and V600EBRAF-mutation for in vitro targeted combination therapy of thyroid carcinomas
Ingår i JMIR Cancer, 2023
- DOI för Positive Design Framework for Carer-eSupport: A Qualitative Study to Support Informal Caregivers of Patients with Head and Neck Cancer in Sweden
- Ladda ner fulltext (pdf) av Positive Design Framework for Carer-eSupport: A Qualitative Study to Support Informal Caregivers of Patients with Head and Neck Cancer in Sweden
Ingår i European Journal of Oncology Nursing, 2023
- DOI för Understanding the challenges and need for support of informal caregivers to individuals with head and neck cancer - A basis for developing internet-based support
- Ladda ner fulltext (pdf) av Understanding the challenges and need for support of informal caregivers to individuals with head and neck cancer - A basis for developing internet-based support
National Knowledge-Driven Management of Obstructive Sleep Apnea: The Swedish Approach
Ingår i Diagnostics, 2023
- DOI för National Knowledge-Driven Management of Obstructive Sleep Apnea: The Swedish Approach
- Ladda ner fulltext (pdf) av National Knowledge-Driven Management of Obstructive Sleep Apnea: The Swedish Approach
Ingår i Cancers, 2023
- DOI för High Levels of FGF11 Correlate with Poor Survival in Patients with Human Papillomavirus (HPV)-Positive Oropharyngeal Squamous Cell Carcinoma
- Ladda ner fulltext (pdf) av High Levels of FGF11 Correlate with Poor Survival in Patients with Human Papillomavirus (HPV)-Positive Oropharyngeal Squamous Cell Carcinoma
Ingår i International Wound Journal, s. 120-130, 2023
- DOI för Lugol's solution and Gentian violet eradicate methicillin-resistant Staphylococcus aureus biofilm in skin wound infections
- Ladda ner fulltext (pdf) av Lugol's solution and Gentian violet eradicate methicillin-resistant Staphylococcus aureus biofilm in skin wound infections
Ingår i Cancer Medicine, s. 12524-12534, 2023
- DOI för Sentinel node-assisted neck dissection in advanced oral squamous cell carcinoma - A new protocol for staging and treatment
- Ladda ner fulltext (pdf) av Sentinel node-assisted neck dissection in advanced oral squamous cell carcinoma - A new protocol for staging and treatment
The impact of waiting time on hearing outcome and patients' satisfaction after cholesteatoma surgery
Ingår i Acta Oto-Laryngologica, s. 662-668, 2023
- DOI för The impact of waiting time on hearing outcome and patients' satisfaction after cholesteatoma surgery
- Ladda ner fulltext (pdf) av The impact of waiting time on hearing outcome and patients' satisfaction after cholesteatoma surgery
Ingår i Oral surgery, oral medicine, oral pathology and oral radiology, s. 691-702, 2023
- DOI för Oral manifestations and dental considerations of patients with hereditary hemorrhagic telangiectasia: a scoping review
- Ladda ner fulltext (pdf) av Oral manifestations and dental considerations of patients with hereditary hemorrhagic telangiectasia: a scoping review
Ingår i Clinical Otolaryngology, s. 895-901, 2023
- DOI för Prophylactic antibiotics has no benefit for outcome in clean myringoplasty-A register-based cohort study from SwedEar
- Ladda ner fulltext (pdf) av Prophylactic antibiotics has no benefit for outcome in clean myringoplasty-A register-based cohort study from SwedEar
Auditory brainstem implant pitch discrimination and auditory outcome
Ingår i ACTA OTO-LARYNGOLOGICA CASE REPORTS, s. 39-43, 2022
- DOI för Auditory brainstem implant pitch discrimination and auditory outcome
- Ladda ner fulltext (pdf) av Auditory brainstem implant pitch discrimination and auditory outcome
Ingår i Cancers, 2022
- DOI för Longitudinal Changes in the Fatty Acid Profile in Patients with Head and Neck Cancer: Associations with Treatment and Inflammatory Response
- Ladda ner fulltext (pdf) av Longitudinal Changes in the Fatty Acid Profile in Patients with Head and Neck Cancer: Associations with Treatment and Inflammatory Response
Ingår i Acta Oncologica, s. 433-440, 2022
- DOI för Base of tongue squamous cell carcinomas, outcome depending on treatment strategy and p16 status. A population-based study from the Swedish Head and Neck Cancer Register
- Ladda ner fulltext (pdf) av Base of tongue squamous cell carcinomas, outcome depending on treatment strategy and p16 status. A population-based study from the Swedish Head and Neck Cancer Register
Ingår i Frontiers in Molecular Neuroscience, 2022
- DOI för GJB2 and GJB6 gene transcripts in the human cochlea: A study using RNAscope, confocal, and super-resolution structured illumination microscopy
- Ladda ner fulltext (pdf) av GJB2 and GJB6 gene transcripts in the human cochlea: A study using RNAscope, confocal, and super-resolution structured illumination microscopy
Pediatric Obstructive Sleep Apnea: Evaluation of surgical treatments and immunological aspects
2022
Ingår i Cancers, 2022
- DOI för Higher Risk of Recurrence in Patients Treated for Head and Neck Cancer with Low BMI and Elevated Levels of C-Reactive Protein
- Ladda ner fulltext (pdf) av Higher Risk of Recurrence in Patients Treated for Head and Neck Cancer with Low BMI and Elevated Levels of C-Reactive Protein
Unlocking the human inner ear for therapeutic intervention
Ingår i Scientific Reports, 2022
- DOI för Unlocking the human inner ear for therapeutic intervention
- Ladda ner fulltext (pdf) av Unlocking the human inner ear for therapeutic intervention
Ingår i Acta Oto-Laryngologica, s. 78-83, 2022
- DOI för Mandibular resection in patients with head and neck cancer: acute and long-term complications after reconstruction
- Ladda ner fulltext (pdf) av Mandibular resection in patients with head and neck cancer: acute and long-term complications after reconstruction
Designing for Human Well-Being: A Case Study with Informal Caregivers of Individuals with Cancer
Ingår i Studies in Health Technology and Informatics, s. 214-218, 2022
- DOI för Designing for Human Well-Being: A Case Study with Informal Caregivers of Individuals with Cancer
- Ladda ner fulltext (pdf) av Designing for Human Well-Being: A Case Study with Informal Caregivers of Individuals with Cancer