Katarina Edwards group
![Edwards introbild](/images/200.75e37daa18e79b469f4269d5/1712213980345/Edwards_image.jpg)
Colloid and Interface Chemistry
Our research
Our research within colloid and interface chemistry is focused on soft surfaces and colloidal systems formed by lipids and surfactants. An overall aim of the investigations is to gain a deeper understanding of the factors that govern molecular interactions, membrane properties and structural transformations in systems containing liposomes and related self-assembled lipid structures.
The projects are as a rule inspired by issues of biological or medical / pharmaceutical relevance, and the information gained from the fundamental studies is often utilized in more applied sub-projects. In particular, we develop and characterize systems designed in order to obtain efficient nanocarriers for controlled drug delivery, as well as improved model membranes and sensor surfaces for biomolecular analysis.
Our research projects
An important objective is to utilize the information gained from fundamental investigations to help explain events and mechanisms of biological and medical/pharmaceutical relevance. In addition, the aim is to retrieve information of value for a number of more applied sub-projects. Projects belonging to this category focus on the development of improved model membranes, tailored surfaces for biomolecular analysis, and efficient lipid-based carriers for controlled drug delivery.
Experimental techniques
Our experimental techniques:
- Cryo-transmission electron microscopy (cryo-TEM)
- QCM-D
- Other techniques
Group members
Publications
Dual centrifugation as a novel and efficient method for the preparation of lipodisks
Part of International Journal of Pharmaceutics, 2024
- DOI for Dual centrifugation as a novel and efficient method for the preparation of lipodisks
- Download full text (pdf) of Dual centrifugation as a novel and efficient method for the preparation of lipodisks
Part of Soft Matter, p. 2272-2279, 2024
- DOI for Investigation of supramolecular structures in various aqueous solutions of an amyloid forming peptide using small-angle X-ray scattering
- Download full text (pdf) of Investigation of supramolecular structures in various aqueous solutions of an amyloid forming peptide using small-angle X-ray scattering
Part of Biochimica et Biophysica Acta - Biomembranes, 2024
- DOI for A closer look at calcium-induced interactions between phosphatidylserine-(PS) doped liposomes and the structural effects caused by inclusion of gangliosides or polyethylene glycol- (PEG) modified lipids
- Download full text (pdf) of A closer look at calcium-induced interactions between phosphatidylserine-(PS) doped liposomes and the structural effects caused by inclusion of gangliosides or polyethylene glycol- (PEG) modified lipids
Part of Langmuir, p. 11337-11344, 2023
- DOI for Spontaneous Formation of Ultrasmall Unilamellar Vesicles in Mixtures of an Amphiphilic Drug and a Phospholipid
- Download full text (pdf) of Spontaneous Formation of Ultrasmall Unilamellar Vesicles in Mixtures of an Amphiphilic Drug and a Phospholipid
Part of Colloids and Surfaces B, 2023
- DOI for Improved accuracy and reproducibility of spontaneous liposome leakage measurements by the use of supported lipid bilayer-modified quartz cuvettes
- Download full text (pdf) of Improved accuracy and reproducibility of spontaneous liposome leakage measurements by the use of supported lipid bilayer-modified quartz cuvettes
Tailoring the Lamellarity of Liposomes Prepared by Dual Centrifugation
Part of Pharmaceutics, 2023
- DOI for Tailoring the Lamellarity of Liposomes Prepared by Dual Centrifugation
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Part of Physical Chemistry, Chemical Physics - PCCP, p. 2935-2945, 2023
- DOI for Excited-state and charge-carrier dynamics in binary conjugated polymer dots towards efficient photocatalytic hydrogen evolution
- Download full text (pdf) of Excited-state and charge-carrier dynamics in binary conjugated polymer dots towards efficient photocatalytic hydrogen evolution
Part of FEMS Microbiology Ecology, 2023
- DOI for Vesicle-enriched secretomes alter bacterial competitive abilities and are drivers of evolution in microbial communities
- Download full text (pdf) of Vesicle-enriched secretomes alter bacterial competitive abilities and are drivers of evolution in microbial communities
Avoiding artifacts in liposome leakage measurements via cuvette- and liposome-surface modifications
Part of Journal of liposome research, p. 237-249, 2022
- DOI for Avoiding artifacts in liposome leakage measurements via cuvette- and liposome-surface modifications
- Download full text (pdf) of Avoiding artifacts in liposome leakage measurements via cuvette- and liposome-surface modifications
Part of Journal of the American Chemical Society, p. 13600-13611, 2022
- DOI for Polymer Dots as Photoactive Membrane Vesicles for [FeFe]-Hydrogenase Self-Assembly and Solar-Driven Hydrogen Evolution
- Download full text (pdf) of Polymer Dots as Photoactive Membrane Vesicles for [FeFe]-Hydrogenase Self-Assembly and Solar-Driven Hydrogen Evolution
Part of Small, 2022
Part of Molecular Pharmaceutics, p. 1068-1077, 2022
- DOI for Structural Characterization Study of a Lipid Nanocapsule Formulation Intended for Drug Delivery Applications Using Small-Angle Scattering Techniques
- Download full text (pdf) of Structural Characterization Study of a Lipid Nanocapsule Formulation Intended for Drug Delivery Applications Using Small-Angle Scattering Techniques
Part of Soft Matter, p. 7769-7780, 2021
Adhesion and Structural Changes of PEGylated LipidNanocarriers on Silica Surfaces
Part of PhysChem, p. 133-151, 2021
- DOI for Adhesion and Structural Changes of PEGylated LipidNanocarriers on Silica Surfaces
- Download full text (pdf) of Adhesion and Structural Changes of PEGylated LipidNanocarriers on Silica Surfaces
Part of Journal of the American Chemical Society, p. 2875-2885, 2021
- DOI for Panchromatic Ternary Polymer Dots Involving Sub-Picosecond Energy and Charge Transfer for Efficient and Stable Photocatalytic Hydrogen Evolution
- Download full text (pdf) of Panchromatic Ternary Polymer Dots Involving Sub-Picosecond Energy and Charge Transfer for Efficient and Stable Photocatalytic Hydrogen Evolution
Part of International Journal of Pharmaceutics, p. 120640, 2021
- DOI for Formulation development and upscaling of lipid nanocapsules as a drug delivery system for a novel cyclic GMP analogue intended for retinal drug delivery
- Download full text (pdf) of Formulation development and upscaling of lipid nanocapsules as a drug delivery system for a novel cyclic GMP analogue intended for retinal drug delivery
Effect of gangliosides on structure and integrity of polyethylene glycol(PEG)-stabilized liposomes
Part of Journal of Colloid and Interface Science, p. 281-289, 2020
- DOI for Effect of gangliosides on structure and integrity of polyethylene glycol(PEG)-stabilized liposomes
- Download full text (pdf) of Effect of gangliosides on structure and integrity of polyethylene glycol(PEG)-stabilized liposomes
Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks
Part of Nanomaterials, 2020
- DOI for Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks
- Download full text (pdf) of Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks
Osmoprotective effect of ubiquinone in lipid vesicles modelling the E. coli plasma membrane
Part of Biochimica et Biophysica Acta - Biomembranes, p. 1388-1396, 2019
- DOI for Osmoprotective effect of ubiquinone in lipid vesicles modelling the E. coli plasma membrane
- Download full text (pdf) of Osmoprotective effect of ubiquinone in lipid vesicles modelling the E. coli plasma membrane
Part of ACS - Infectious Diseases, p. 1867-1878, 2019
Part of Journal of Colloid and Interface Science, p. 126-135, 2018
Part of Biochimica et Biophysica Acta - Biomembranes, p. 1205-1215, 2018
- DOI for Effect of ubiquinone-10 on the stability of biomimetic membranes of relevance for the inner mitochondrial membrane.
- Download full text (pdf) of Effect of ubiquinone-10 on the stability of biomimetic membranes of relevance for the inner mitochondrial membrane.
Part of RSC Advances, p. 22178-22186, 2017
- DOI for EGF-targeting lipodisks for specific delivery of poorly water-soluble anticancer agents to tumour cells
- Download full text (pdf) of EGF-targeting lipodisks for specific delivery of poorly water-soluble anticancer agents to tumour cells
Targeting lipodisks enable selective delivery of anticancer peptides to tumor cells
Part of Nanomedicine, p. 2325-2328, 2017
Part of International Journal of Pharmaceutics, p. 400-412, 2017
Distinct modulatory role of RNA in the aggregation of the tumor suppressor protein p53 core domain.
Part of Journal of Biological Chemistry, p. 9345-9357, 2017
Part of Nanomedicine, p. 2517-2521, 2017
A Biocompatible Synthetic Lung Fluid Based on Human Respiratory Tract Lining Fluid Composition.
Part of Pharmaceutical research, p. 2454-2465, 2017
- DOI for A Biocompatible Synthetic Lung Fluid Based on Human Respiratory Tract Lining Fluid Composition.
- Download full text (pdf) of A Biocompatible Synthetic Lung Fluid Based on Human Respiratory Tract Lining Fluid Composition.
Part of Journal of Controlled Release, p. 50-61, 2017
- DOI for A simple passive equilibration method for loading carboplatin into pre-formed liposomes incubated with ethanol as a temperature dependent permeability enhancer.
- Download full text (pdf) of A simple passive equilibration method for loading carboplatin into pre-formed liposomes incubated with ethanol as a temperature dependent permeability enhancer.
Part of Langmuir, p. 4217-4228, 2016
Part of Colloids and Surfaces B, p. 576-583, 2016
Part of The Analyst, p. 981-988, 2016
Part of Nanomedicine, p. 1033-1043, 2016
Optimization of Lipodisk Properties by Modification of the Extent and Density of the PEG Corona
Part of Journal of Colloid and Interface Science, p. 86-96, 2016
- DOI for Optimization of Lipodisk Properties by Modification of the Extent and Density of the PEG Corona
- Download full text (pdf) of Optimization of Lipodisk Properties by Modification of the Extent and Density of the PEG Corona
Part of Langmuir, p. 12091-12099, 2016
Part of PLOS ONE, 2016
- DOI for Nanoscale Reaction Vessels Designed for Synthesis of Copper-Drug Complexes Suitable for Preclinical Development
- Download full text (pdf) of Nanoscale Reaction Vessels Designed for Synthesis of Copper-Drug Complexes Suitable for Preclinical Development
Ubiquinone-10 alters mechanical properties and increases stability of phospholipid membranes
Part of Biochimica et Biophysica Acta - Biomembranes, p. 2233-2243, 2015
- DOI for Ubiquinone-10 alters mechanical properties and increases stability of phospholipid membranes
- Download full text (pdf) of Ubiquinone-10 alters mechanical properties and increases stability of phospholipid membranes
Halogenated Dodecaborate Clusters as Agents to Trigger Release of Liposomal Contents
Part of ChemPlusChem, p. 656-664, 2015
Part of Journal of Drug Delivery Science and Technology, p. 90-98, 2015
Part of Langmuir, p. 741-751, 2015
Part of The Analyst, p. 303-312, 2015
Part of Biochimica et Biophysica Acta - Biomembranes, p. 1862-1870, 2014
- DOI for Heterologous overexpression of a monotopic glucosyltransferase (MGS) induces fatty acid remodeling in Escherichia coli membranes
- Download full text (pdf) of Heterologous overexpression of a monotopic glucosyltransferase (MGS) induces fatty acid remodeling in Escherichia coli membranes
Part of Langmuir, p. 3928-3938, 2014
Part of Journal of Colloid and Interface Science, p. 111-120, 2014
- DOI for Impact of interfacial cholesterol-anchored polyethylene glycol on sterol-rich non-phospholipid liposomes
- Download full text (pdf) of Impact of interfacial cholesterol-anchored polyethylene glycol on sterol-rich non-phospholipid liposomes
Diastereoselective self-assembly of clofarabine lipids
Part of New Journal of Chemistry, p. 5247-5253, 2014
Label-Free Characterization of Peptide-Lipid Interactions Using Immobilized Lipodisks
Part of Analytical Chemistry, p. 7377-7384, 2013
- DOI for Label-Free Characterization of Peptide-Lipid Interactions Using Immobilized Lipodisks
- Download full text (pdf) of Label-Free Characterization of Peptide-Lipid Interactions Using Immobilized Lipodisks
Part of Langmuir, p. 11834-11848, 2013
Part of Journal of Chromatography A, p. 105-109, 2013
Part of Journal of Physical Chemistry B, p. 2019-2025, 2013
Immobilized lipodisks as model membranes in high-throughput HPLC-MS analysis
Part of Analytical and Bioanalytical Chemistry, p. 4859-4869, 2013
- DOI for Immobilized lipodisks as model membranes in high-throughput HPLC-MS analysis
- Download full text (pdf) of Immobilized lipodisks as model membranes in high-throughput HPLC-MS analysis
Contact
- If you have questions about our research, you are welcome to contact Katarina Edwards.
- Katarina Edwards