Globisch Group
![Schematic picture of the research in the Globisch group describing the following steps: Sampling is symbolised by three Eppendorf tubes with different coloured contents. Isolation of metabolites is symbolised by a vial containing various substances. Analysis of metabolites is symbolised by a mass spectrometer. Data analysis is symbolised by three charts. Identification of individual metabolites is symbolised by a mass spectrum.](/images/200.21e11cd618fa418474b40e6b/1717158358506/Globisch_startsida_1932px.jpg)
Biomarker discovery, chemical biology, organic chemistry, mass spectrometry, and metabolomics
Biomarker discovery is a challenging and multidisciplinary task. We develop new tools for mass spectrometric analysis of complex samples and are focussed on elucidating microbiota metabolism. We investigate any human sample type, e.g. fecal, urine, and plasma samples from pancreatic cancer patients.
Publications
Part of Angewandte Chemie International Edition, 2024
- DOI for Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4‐Nitrophenyl‐2H‐azirine
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Identification of New Ketamine Metabolites and Their Detailed Distribution in the Mammalian Brain
Part of ACS Chemical Neuroscience, p. 1335-1341, 2024
- DOI for Identification of New Ketamine Metabolites and Their Detailed Distribution in the Mammalian Brain
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The protective role of commensal gut microbes and their metabolites against bacterial pathogens
Part of Gut microbes, 2024
- DOI for The protective role of commensal gut microbes and their metabolites against bacterial pathogens
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A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken
Part of PLOS Genetics, 2023
- DOI for A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken
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Part of Analytical Chemistry, p. 12565-12571, 2023
- DOI for Immobilized Enzymes on Magnetic Beads for Separate Mass Spectrometric Investigation of Human Phase II Metabolite Classes
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Identification of nutritional biomarkers through highly sensitive and chemoselective metabolomics
Part of Food Chemistry, 2023
- DOI for Identification of nutritional biomarkers through highly sensitive and chemoselective metabolomics
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Part of Chemical Science, p. 5291-5301, 2023
- DOI for Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites
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Part of Chemical Communications, p. 5843-5846, 2023
Part of Journal of Crohn's & Colitis, p. 418-432, 2023
- DOI for Mucosal and Plasma Metabolomes in New-onset Paediatric Inflammatory Bowel Disease: Correlations with Disease Characteristics and Plasma Inflammation Protein Markers
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Regional Brain Analysis of Modified Amino Acids and Dipeptides during the Sleep/Wake Cycle
Part of Metabolites, 2022
- DOI for Regional Brain Analysis of Modified Amino Acids and Dipeptides during the Sleep/Wake Cycle
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Part of Biochemical Pharmacology, 2022
- DOI for Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity
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Part of Microbiology Spectrum, 2022
- DOI for Analysis of Growth Phases of Enterotoxigenic Escherichia coli Reveals a Distinct Transition Phase before Entry into Early Stationary Phase with Shifts in Tryptophan, Fucose, and Putrescine Metabolism and Degradation of Neurotransmitter Precursors
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Part of Journal of Experimental & Clinical Cancer Research, 2021
- DOI for Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis
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Part of Journal of Cerebral Blood Flow and Metabolism, p. 3324-3338, 2021
- DOI for Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep
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Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites
Part of Angewandte Chemie International Edition, p. 23232-23240, 2021
- DOI for Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites
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Part of RSC CHEMICAL BIOLOGY, p. 1479-1483, 2021
- DOI for Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines
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Part of RSC Advances, p. 34788-34794, 2021
- DOI for Investigation of the individual human sulfatome in plasma and urine samples reveals an age-dependency
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Part of Journal of Pharmaceutical and Biomedical Analysis, 2021
- DOI for Comparison of two arylsulfatases for targeted mass spectrometric analysis of microbiota-derived metabolites
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Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World
Part of Chemistry - A European Journal, p. 14856-14860, 2020
- DOI for Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World
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Rapid Preparation of a Large Sulfated Metabolite Library for Structure Validation in Human Samples
Part of Metabolites, 2020
- DOI for Rapid Preparation of a Large Sulfated Metabolite Library for Structure Validation in Human Samples
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Part of Free Radical Biology & Medicine, p. 745-754, 2020
- DOI for Comparative dietary sulfated metabolome analysis reveals unknown metabolic interactions of the gut microbiome and the human host
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DNA surface exploration and operator bypassing during target search
Part of Nature, p. 858-+, 2020
- DOI for DNA surface exploration and operator bypassing during target search
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Part of The Analyst, p. 3822-3831, 2020
- DOI for Sensitive mass spectrometric analysis of carbonyl metabolites in human urine and fecal samples using chemoselective modification
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Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2
Part of Angewandte Chemie International Edition, p. 14342-14346, 2020
- DOI for Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2
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Part of Chemical Communications, p. 9080-9083, 2019
- DOI for Chemoselective probe for detailed analysis of ketones and aldehydes produced by gut microbiota in human samples
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Part of Bioorganic & Medicinal Chemistry, p. 955-962, 2019
Part of ChemBioChem (Print), p. 1678-1683, 2019
Part of Organic and biomolecular chemistry, p. 698-702, 2018
Part of Chemical Science, p. 6233-6239, 2018
- DOI for New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites
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Part of Angewandte Chemie International Edition, p. 13805-13809, 2018
Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis
Part of ACS - Infectious Diseases, p. 1423-1431, 2018
- DOI for Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis
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Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG)
Part of Bioorganic & Medicinal Chemistry Letters, p. 3436-3440, 2017