Danielson Group

Multiplexed experimental strategies for fragment library screening against challenging drug targets using SPR biosensors

FitzGerald, Edward; Vagrys, Darius; Opassi, Giulia; Klein, Hanna F. et al.

Part of SLAS Discovery, p. 40-51, 2024

• DOI for Multiplexed experimental strategies for fragment library screening against challenging drug targets using SPR biosensors
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Amino acid substitutions in human growth hormone affect secondary structure and receptor binding

Rajkovic, Andrei; Kanchugal Puttaswamy, Sandesh; Abdurakhmanov, Eldar; Howard, Rebecca et al.

Part of PLOS ONE, 2023

• DOI for Amino acid substitutions in human growth hormone affect secondary structure and receptor binding
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The Crystal Structure of Tyrosinase from Verrucomicrobium spinosum Reveals It to Be an Atypical Bacterial Tyrosinase

Fekry, Mostafa; Dave, Khyati K.; Badgujar, Dilip; Hamnevik, Emil et al.

Part of Biomolecules, 2023

• DOI for The Crystal Structure of Tyrosinase from Verrucomicrobium spinosum Reveals It to Be an Atypical Bacterial Tyrosinase
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The Allosteric Regulation of Β-Ureidopropionase Depends on Fine-Tuned Stability of Active-Site Loops and Subunit Interfaces

Cederfelt, Daniela; Badgujar, Dilip; Au Musse, Ayan; Lohkamp, Bernhard et al.

Part of Biomolecules, 2023

• DOI for The Allosteric Regulation of Β-Ureidopropionase Depends on Fine-Tuned Stability of Active-Site Loops and Subunit Interfaces
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Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ

Al-Amin, Rasel A.; Johansson, Lars; Abdurakhmanov, Eldar; Landegren, Nils et al.

Part of Nucleic Acids Research, 2022

• DOI for Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ
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Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3

Parenti, Marco Daniele; Naldi, Marina; Manoni, Elisabetta; Fabini, Edoardo et al.

Part of European Journal of Medicinal Chemistry, 2022

• DOI for Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3

Sensitive protein detection using site-specifically oligonucleotide-conjugated nanobody reagents

Al-Amin, Rasel Abdullah; Muthelo, Phathutshedzo M.; Abdurakhmanov, Eldar; Vincke, Cecile et al.

Part of Analytical Chemistry, p. 10054-10061, 2022

• DOI for Sensitive protein detection using site-specifically oligonucleotide-conjugated nanobody reagents
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Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

Luttens, Andreas; Gullberg, Hjalmar; Abdurakhmanov, Eldar; Vo, Duy Duc et al.

Part of Journal of the American Chemical Society, p. 2905-2920, 2022

• DOI for Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses
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Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase

Talibov, Vladimir O; Fabini, Edoardo; FitzGerald, Edward; Tedesco, Daniele et al.

Part of ChemBioChem (Print), p. 1597-1608, 2021

• DOI for Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase
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Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor

FitzGerald, Edward A.; Butko, Margaret T.; Boronat, Pierre; Cederfelt, Daniela et al.

Part of RSC Advances, p. 7527-7537, 2021

• DOI for Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor
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Fibrin fragment E potentiates TGF-beta-induced myofibroblast activation and recruitment

Öhman Fuchs, Peder; Calitz, Carlemi; Pavlovic, Natasa; Binet, Francois et al.

Part of Cellular Signalling, 2020

• DOI for Fibrin fragment E potentiates TGF-beta-induced myofibroblast activation and recruitment
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A real-time cell-binding assay reveals dynamic features of STxB-Gb3 cointernalization and STxB-mediated cargo delivery into cancer cells

Encarnacao, Joao Crispim; Napolitano, Valeria; Opassi, Giulia; Danielson, U. Helena et al.

Part of FEBS Letters, p. 2406-2420, 2020

• DOI for A real-time cell-binding assay reveals dynamic features of STxB-Gb3 cointernalization and STxB-mediated cargo delivery into cancer cells
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Establishing Trypanosoma cruzi farnesyl pyrophosphatesynthase as a viable target for biosensor driven fragment-based lead discovery

Opassi, Giulia; Nordström, Helena; Lundin, Arne; Napolitano, Valeria et al.

Part of Protein Science, p. 991-1003, 2020

• DOI for Establishing Trypanosoma cruzi farnesyl pyrophosphatesynthase as a viable target for biosensor driven fragment-based lead discovery
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Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1

Yang, Jie; Talibov, Vladimir O; Peintner, Stefan; Rhee, Claire et al.

Part of ACS Omega, p. 3979-3995, 2020

• DOI for Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1
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Estimating Detection Limits of Potentiometric DNA sensors Using Surface Plasmon Resonance Analyses

Xu, Xingxing; Makaraviciute, Asta; Abdurakhmanov, Eldar; Werneling, Fredrik et al.

Part of ACS Sensors, p. 217-224, 2020

• DOI for Estimating Detection Limits of Potentiometric DNA sensors Using Surface Plasmon Resonance Analyses

Unveiling the Biochemistry of the Epigenetic Regulator SMYD3

Fabini, Edoardo; Talibov, Vladimir O; Mihalic, Filip; Naldi, Marina et al.

Part of Biochemistry, p. 3634-3645, 2019

• DOI for Unveiling the Biochemistry of the Epigenetic Regulator SMYD3

Structural Changes of Mercaptohexanol Self-assembled Monolayers on Gold and their Influence on Impedimetric Aptamer Sensors

Xu, Xingxing; Makaraviciute, Asta; Kumar, Shalen; Wen, Chenyu et al.

Part of Analytical Chemistry, p. 14697-14704, 2019

• DOI for Structural Changes of Mercaptohexanol Self-assembled Monolayers on Gold and their Influence on Impedimetric Aptamer Sensors

Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold

Belfrage, Anna Karin; Abdurakhmanov, Eldar; Åkerblom, Eva; Brandt, Peter et al.

Part of European Journal of Medicinal Chemistry, p. 453-464, 2018

• DOI for Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold

Introduction of Intrinsic Kinetics of Protein-Ligand Interactions and Their Implications for Drug Design

Linkuviene, Vaida; Talibov, Vladimir O; Danielson, U. Helena; Matulis, Daumantas

Part of Journal of Medicinal Chemistry, p. 2292-2302, 2018

• DOI for Introduction of Intrinsic Kinetics of Protein-Ligand Interactions and Their Implications for Drug Design

Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors

Pandya, Nikhil J; Seeger, Christian; Babai, Norbert; Gonzalez-Lozano, Miguel A et al.

Part of Cell Reports, p. 1218-1230, 2018

• DOI for Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors
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Development of a novel therapeutic vaccine carrier that sustains high antibody titers against several targets simultaneously

Saupe, Falk; Reichel, Matthias; Huijbers, Elisabeth J. M.; Femel, Julia et al.

Part of The FASEB Journal, p. 1204-1214, 2017

• DOI for Development of a novel therapeutic vaccine carrier that sustains high antibody titers against several targets simultaneously

Monitoring drug-serum protein interactions for early ADME prediction through Surface Plasmon Resonance technology

Fabini, Edoardo; Danielson, U. Helena

Part of Journal of Pharmaceutical and Biomedical Analysis, p. 188-194, 2017

• DOI for Monitoring drug-serum protein interactions for early ADME prediction through Surface Plasmon Resonance technology

Insights from engineering the Affibody-Fc interaction with a computational-experimental method

Nosrati, Masoumeh; Solbak, Sara; Nordesjö, Olle; Nissbeck, Mikael et al.

Part of Protein Engineering Design & Selection, p. 593-601, 2017

• DOI for Insights from engineering the Affibody-Fc interaction with a computational-experimental method

Biophysical analysis of the dynamics of calmodulin interactions with neurogranin and Ca²⁺/calmodulin-dependent kinase II

Seeger, Christian; Talibov, Vladimir O; Danielson, U. Helena

Part of Journal of Molecular Recognition, p. 1-11, 2017

• DOI for Biophysical analysis of the dynamics of calmodulin interactions with neurogranin and Ca²⁺/calmodulin-dependent kinase II
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Intrinsic vs. observed thermodynamic and kinetic parameters of carbonic anhydrase-ligand interaction

Linkuviene, V.; Talibov, Vladimir O.; Danielson, U. Helena; Matulis, D.

Part of European Biophysics Journal, 2017

• DOI for Intrinsic vs. observed thermodynamic and kinetic parameters of carbonic anhydrase-ligand interaction

Intrinsic vs. observed thermodynamic and kinetic parameters of carbonic anhydrase-ligand interaction

Linkuviene, V.; Talibov, Vladimir O; Danielson, U. Helena; Matulis, D.

Part of European Biophysics Journal, 2017

• DOI for Intrinsic vs. observed thermodynamic and kinetic parameters of carbonic anhydrase-ligand interaction

Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition

Solbak, Sara M.Ø.; Abdurakhmanov, Eldar; Vedeler, Anni; Danielson, U. Helena

Part of Virology Journal, 2017

• DOI for Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition
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Biophysical Mode-of-Action and Selectivity Analysis of Allosteric Inhibitors of Hepatitis C Virus (HCV) Polymerase

Abdurakhmanov, Eldar; Solbak, Sara Oie; Danielson, U. Helena

Part of Viruses, 2017

• DOI for Biophysical Mode-of-Action and Selectivity Analysis of Allosteric Inhibitors of Hepatitis C Virus (HCV) Polymerase
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Let There Be Light!

Raykova, Doroteya; Koos, Bjoern; Asplund, Anna; Gelleri, Marton et al.

Part of Proteomes, 2016

• DOI for Let There Be Light!
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Biophysics in drug discovery: impact, challenges and opportunities

Renaud, Jean-Paul; Chung, Chun-wa; Danielson, U. Helena; Egner, Ursula et al.

Part of Nature reviews. Drug discovery, p. 679-698, 2016

• DOI for Biophysics in drug discovery: impact, challenges and opportunities

Kinetically Selective Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII

Talibov, Vladimir O; Linkuvienė, Vaida; Matulis, Daumantas; Danielson, Helena U.

Part of Journal of Medicinal Chemistry, p. 2083-2093, 2016

• DOI for Kinetically Selective Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII

Discovery of pyrazinone based compounds that potently inhibit the drug resistant enzyme variant R155K of the hepatitis C virus NS3 protease

Belfrage, Anna Karin; Abdurakhmanov, Eldar; Åkerblom, Eva; Brandt, Peter et al.

Part of Bioorganic & Medicinal Chemistry, p. 2603-2620, 2016

• DOI for Discovery of pyrazinone based compounds that potently inhibit the drug resistant enzyme variant R155K of the hepatitis C virus NS3 protease

Identification and Characterization of an Irreversible Inhibitor of CDK2

Anscombe, Elizabeth; Meschini, Elisa; Mora-Vidal, Regina; Martin, Mathew P. et al.

Part of Chemistry and Biology, p. 1159-1164, 2015

• DOI for Identification and Characterization of an Irreversible Inhibitor of CDK2
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Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the alpha 7 nicotinic acetylcholine receptor

Spurny, Radovan; Debaveye, Sarah; Farinha, Ana; Veys, Ken et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2015

• DOI for Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the alpha 7 nicotinic acetylcholine receptor

Molecular Interaction Analysis for Discovery of Drugs Targeting Enzymes and for Resolving Biological Function

Danielson, U. Helena

Part of Multifaceted Roles Of Crystallography In Modern Drug Discovery, p. 223-240, 2015

• DOI for Molecular Interaction Analysis for Discovery of Drugs Targeting Enzymes and for Resolving Biological Function

Proximity-dependent initiation of hybridization chain reaction

Koos, Björn; Cane, Gaëlle; Grannas, Karin; Löf, Liza et al.

Part of Nature Communications, 2015

• DOI for Proximity-dependent initiation of hybridization chain reaction
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Analysis of the leakage of gene repression by an artificial TetR-regulated promoter in cyanobacteria

Danielson, U Helena; Huang, H H; Seeger, Christian; Lindblad, Peter

Part of BMC Research Notes, p. 459, 2015

Analysis of the leakage of gene repression by an artificial TetR-regulated promoter in cyanobacteria

Huang, Hsin-Ho; Seeger, Christian; Danielson, U. Helena; Lindblad, Peter

Part of BMC Research Notes, 2015

• DOI for Analysis of the leakage of gene repression by an artificial TetR-regulated promoter in cyanobacteria
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Identification of weak points of hepatitis C virus NS3 protease inhibitors using surface plasmon resonance biosensor-based interaction kinetic analysis and genetic variants

Svahn Gustafsson, Sofia; Ehrenberg, Angelica; Schmuck, Benjamin; Anwar, Mohammed Ikram et al.

Part of Journal of Medicinal Chemistry, p. 1802-1811, 2014

Identification and characterization of an irreversible inhibitor of CDK2

Martin, M.; Anscombe, E.; Meschini, E.; Staunton, D. et al.

Part of European Journal of Cancer, p. 106-106, 2014

• DOI for Identification and characterization of an irreversible inhibitor of CDK2

The Versatile Nature of the 6-Aminoquinolone Scaffold: Identification of Submicromolar Hepatitis C Virus NS5B Inhibitors

Manfroni, Giuseppe; Cannalire, Rolando; Barreca, Maria Letizia; Kaushik-Basu, Neerja et al.

Part of Journal of Medicinal Chemistry, p. 1952-1963, 2014

• DOI for The Versatile Nature of the 6-Aminoquinolone Scaffold: Identification of Submicromolar Hepatitis C Virus NS5B Inhibitors

Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Gising, Johan; Belfrage, Anna Karin; Alogheli, Hiba; Ehrenberg, Angelica et al.

Part of Journal of Medicinal Chemistry, p. 1790-1801, 2014

• DOI for Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Identification of Weak Points of Hepatitis C Virus NS3 Protease Inhibitors Using Surface Plasmon Resonance Biosensor-Based Interaction Kinetic Analysis and Genetic Variants

Svahn Gustafsson, Sofia; Ehrenberg, Angelica; Schmuck, Benjamin; Anwar, Muhammad Ikram et al.

Part of Journal of Medicinal Chemistry, p. 1802-1811, 2014

• DOI for Identification of Weak Points of Hepatitis C Virus NS3 Protease Inhibitors Using Surface Plasmon Resonance Biosensor-Based Interaction Kinetic Analysis and Genetic Variants

Accounting for strain variations and resistance mutations in the characterization of hepatitis C NS3 protease inhibitors

Ehrenberg, Angelica; Schmuck, Benjamin; Anwar, Muhammad Ikram; Svahn Gustafsson, Sofia et al.

Part of Journal of enzyme inhibition and medicinal chemistry (Print), p. 868-876, 2014

• DOI for Accounting for strain variations and resistance mutations in the characterization of hepatitis C NS3 protease inhibitors

Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Lampa, Anna; Alogheli, Hiba; Ehrenberg, Angelica E.; Åkerblom, Eva et al.

Part of Bioorganic & Medicinal Chemistry, p. 6595-6615, 2014

• DOI for Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Lampa, Anna; Bergman, Sara; Svahn Gustafsson, Sofia; Alogheli, Hiba et al.

Part of ACS Medicinal Chemistry Letters, p. 249-254, 2014

• DOI for Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Structure-Based Discovery of Pyrazolobenzothiazine Derivatives As Inhibitors of Hepatitis C Virus Replication

Barreca, Maria Letizia; Manfroni, Giuseppe; Leyssen, Pieter; Winquist, Johan et al.

Part of Journal of Medicinal Chemistry, p. 2270-2282, 2013

• DOI for Structure-Based Discovery of Pyrazolobenzothiazine Derivatives As Inhibitors of Hepatitis C Virus Replication

Structural basis of ligand recognition in 5-HT3 receptors

Kesters, D.; Thompson, A. J.; Brams, M.; Van Elk, R. et al.

Part of EMBO Reports, p. 49-56, 2013

• DOI for Structural basis of ligand recognition in 5-HT3 receptors

The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors: characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors

Gossas, Thomas; Nordström, Helena; Xu, Ming-Hua; Sun, Zhi-Hua et al.

Part of MedChemComm, p. 432-442, 2013

• DOI for The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors: characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors

On the Active Site Protonation State in Aspartic Proteases: Implications for Drug Design

Sussman, Fredy; Carmen Villaverde, M.; Dominguez, Jose L.; Danielson, Helena

Part of Current pharmaceutical design, p. 4257-4275, 2013

• DOI for On the Active Site Protonation State in Aspartic Proteases: Implications for Drug Design