Drug delivery platform for optimal intestinal absorption of oral antibiotics
Developing a nanotechnology-based drug delivery platform that enhances the intestinal absorption for poorly permeables, with focus on oral antibiotics.
Details
- Funder: Vinnova
Research scientist: Xiguo He, PhD Student, MSc
Principal investigator: Professor Christel Bergström, Department of Pharmacy, Uppsala University
Scientific and industrial context: Global antibiotic consumption has increased significantly over the last two decades due to improved access to health care. Antimicrobial resistance is a huge threat to global health, and is high priority for public health authorities. It is crucial to identify strategies to improve the oral bioavailability of antibiotics and minimize adverse reactions in the gut to reduce the side effect of most oral antibiotics.
Aim: To improve the oral bioavailability of antibiotics using nanoparticles that are stable in the gastrointestinal tract (GIT), efficient solubilizers of poorly soluble antibiotics and highly membrane-permeable, with the purpose to increase drug delivery to the systemic circulation.
Outcome: A nanotechnology-based drug delivery platform that enhances the intestinal absorption for poorly permeables, with focus on oral antibiotics.