Influence of intestinal colloidal structures and self-assembly on lipid-based formulations for enhancing peptide drug bioavailability

Research scientist: Shahina Akter, MSc
Principal Investigator: Associate Professor Per Larsson, Department of Pharmacy, Uppsala University

Scientific and industrial context: Bioavailability of peptide therapeutics is poor to non-existent when taken orally, which is the preferred route of administration. In general, and small fatty acid-based compounds specifically permeability enhancer, may be used to transiently boost peptide permeability, but this technique is linked with substantial inter- and intra-individual variability, which is not acceptable for disease treatment that requires a long duration of action.

Aim: To develop a hybrid of the small-angle neutron scattering (SANS) and the simulation methods to analyse complex intestinal colloidal structures and lipid-rich water-based formulations.

Outcome: Through the use of this hybrid method, it will be possible to understand the many essential intestinal processes, allowing for a more complete understanding of the constraints and variability associated with the use of permeability enhancer for peptide therapeutics.