Investigation of The Interplay Between Permeation Enhancers, Gi Physiology and Macromolecular Drugs to Facilitate Design of Oral Dosage Forms (finished project)
Enabling the design of novel delivery systems that increase oral absorption of macromolecules and reduce the variability of absorption.
Details
- Funder: Vinnova
Research scientist: Staffan Berg, MSc
Principal Investigator: Professor Christel Bergström, Department of Pharmacy, Uppsala University
Scientific and industrial context: Oral delivery of macromolecular drugs, primarily peptides, proteins and oligonucleotides, remains an outstanding challenge for pharmaceutical scientists; after more than 90 years of attempts, the bioavailability of such molecules remains low and variable.
Aim: The overall aim of the project is to generate new insights to the interplay between permeation enhancers, macromolecular drugs of different physicochemical properties and the intestinal physiology. In vitro and in vivo models will be used to investigate these interactions and to study the absorption of macromolecules.
Outcome: The generated data is expected to enable the design of novel delivery systems that increase oral absorption of macromolecules and reduce the variability of absorption.