Analytical Pharmaceutical Chemistry

Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells

Kopsida, Maria; Clavero, Ada Lerma; Khaled, Jaafar; Balgoma, David et al.

Part of Molecular Metabolism, 2024

• DOI for Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells
• Download full text (pdf) of Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells

Metabolite Profiling of Drugs using Mass Spectrometry: Identification of analytical targets for doping control and improvements of the metabolite search process

Nilsson Broberg, Malin

2024

• Download full text (pdf) of Metabolite Profiling of Drugs using Mass Spectrometry: Identification of analytical targets for doping control and improvements of the metabolite search process

A multivariate data analysis approach for the investigation of in vitro derived metabolites of ACP-105 in comparison with human in vivo metabolites

Nilsson Broberg, Malin; Tillgren Ohlsson, Rebecca; Bondesson, Ulf; Pettersson, Curt et al.

Part of Journal of chromatography. B, 2023

• DOI for A multivariate data analysis approach for the investigation of in vitro derived metabolites of ACP-105 in comparison with human in vivo metabolites
• Download full text (pdf) of A multivariate data analysis approach for the investigation of in vitro derived metabolites of ACP-105 in comparison with human in vivo metabolites

An interlaboratory capillary zone electrophoresis-UV study of various monoclonal antibodies, instruments, and ε-aminocaproic acid lots

Wiesner, Rebecca; Zagst, Holger; Lan, Wenkui; Bigelow, Stewart et al.

Part of Electrophoresis, p. 1247-1257, 2023

• DOI for An interlaboratory capillary zone electrophoresis-UV study of various monoclonal antibodies, instruments, and ε-aminocaproic acid lots
• Download full text (pdf) of An interlaboratory capillary zone electrophoresis-UV study of various monoclonal antibodies, instruments, and ε-aminocaproic acid lots

Combining the targeted and untargeted screening of environmental contaminants reveals associations between PFAS exposure and vitamin D metabolism in human plasma.

Carlsson, Henrik; Sreenivasan, Akshai P.; Erngren, Ida; Larsson, Anders et al.

Part of Environmental Science, p. 1116-1130, 2023

• DOI for Combining the targeted and untargeted screening of environmental contaminants reveals associations between PFAS exposure and vitamin D metabolism in human plasma.
• Download full text (pdf) of Combining the targeted and untargeted screening of environmental contaminants reveals associations between PFAS exposure and vitamin D metabolism in human plasma.

DNA integrity under alkaline conditions: An investigation of factors affecting the comet assay

Bivehed, Erik; Hellman, Björn; Fan, Yuting; Haglöf, Jakob et al.

Part of Mutation research. Genetic toxicology and environmental mutagenesis, 2023

• DOI for DNA integrity under alkaline conditions: An investigation of factors affecting the comet assay
• Download full text (pdf) of DNA integrity under alkaline conditions: An investigation of factors affecting the comet assay

Enantiomeric Separation of Triacylglycerols from Mouse Liver Tissue using CSP-LC-MS/MS

Landström, Sofia

2023

Equine in vivo metabolite profiling of the selective androgen receptor modulator LGD-3303 for doping control

Nilsson Broberg, Malin; Knych, Heather; Bondesson, Ulf; Pettersson, Curt et al.

Part of Journal of Pharmaceutical and Biomedical Analysis, 2023

• DOI for Equine in vivo metabolite profiling of the selective androgen receptor modulator LGD-3303 for doping control
• Download full text (pdf) of Equine in vivo metabolite profiling of the selective androgen receptor modulator LGD-3303 for doping control

Functionalization of cellulose nanofibrils to develop novel ROS-sensitive biomaterials

Palo-Nieto, Carlos; Blasi-Romero, Anna; Sandström, Corine; Balgoma, David et al.

Part of Materials Advances, p. 1555-1565, 2023

• DOI for Functionalization of cellulose nanofibrils to develop novel ROS-sensitive biomaterials
• Download full text (pdf) of Functionalization of cellulose nanofibrils to develop novel ROS-sensitive biomaterials

Identification and Structural Elucidation of Cannabinoid Metabolites in Horse Urine Using UHPLC-HRMS

Morén, Agnes

2023

• Download full text (pdf) of Identification and Structural Elucidation of Cannabinoid Metabolites in Horse Urine Using UHPLC-HRMS

Investigation of degradation of toxic substances in fungal cultures by mass spectrometric techniques

Stenholm, Åke

2023

• Download full text (pdf) of Investigation of degradation of toxic substances in fungal cultures by mass spectrometric techniques

Optimization of a Microsome Incubation Method using Design of Experiment and Investigation of Metabolites Derived from GLPG0492 and LY2452473: For Application in Doping Control

Tillgren Ohlsson, Rebecca

2023

• Download full text (pdf) of Optimization of a Microsome Incubation Method using Design of Experiment and Investigation of Metabolites Derived from GLPG0492 and LY2452473: For Application in Doping Control

Plasma levels of arginines at term pregnancy in relation to mode of onset of labor and mode of childbirth

Akhter, Tansim; Hedeland, Mikael; Bergquist, Jonas; Ubhayasekera, Kumari et al.

Part of American Journal of Reproductive Immunology, 2023

• DOI for Plasma levels of arginines at term pregnancy in relation to mode of onset of labor and mode of childbirth
• Download full text (pdf) of Plasma levels of arginines at term pregnancy in relation to mode of onset of labor and mode of childbirth

Recent capillary electrophoresis applications for upstream and downstream biopharmaceutical process monitoring

van der Burg, Debbie; Josefsson, Leila; Emmer, Åsa; Sänger–van de Griend, Cari E.

Part of TrAC. Trends in analytical chemistry, 2023

• DOI for Recent capillary electrophoresis applications for upstream and downstream biopharmaceutical process monitoring
• Download full text (pdf) of Recent capillary electrophoresis applications for upstream and downstream biopharmaceutical process monitoring

Screening of HETP test conditions and resin storage solutions for HIC

Ronnerfors, Lise-Lotte

2023

• Download full text (pdf) of Screening of HETP test conditions and resin storage solutions for HIC

Strategies for capillary electrophoresis: Method development and validation for pharmaceutical and biological applications-Updated and completely revised edition

Krebs, Finja; Zagst, Holger; Stein, Matthias; Ratih, Ratih et al.

Part of Electrophoresis, p. 1279-1341, 2023

• DOI for Strategies for capillary electrophoresis: Method development and validation for pharmaceutical and biological applications-Updated and completely revised edition
• Download full text (pdf) of Strategies for capillary electrophoresis: Method development and validation for pharmaceutical and biological applications-Updated and completely revised edition

Trials and tribulations of statistical significance in biochemistry and omics

Montero, Olimpio; Hedeland, Mikael; Balgoma, David

Part of TIBS -Trends in Biochemical Sciences. Regular ed., p. 503-512, 2023

• DOI for Trials and tribulations of statistical significance in biochemistry and omics
• Download full text (pdf) of Trials and tribulations of statistical significance in biochemistry and omics

Ammonia Concentration in the Eluent Influences Fragmentation Pattern of Triacylglycerols in Mass Spectrometry Analysis

Velasco, Marta; Balgoma, David; Montero, Olimpio

Part of Metabolites, 2022

• DOI for Ammonia Concentration in the Eluent Influences Fragmentation Pattern of Triacylglycerols in Mass Spectrometry Analysis
• Download full text (pdf) of Ammonia Concentration in the Eluent Influences Fragmentation Pattern of Triacylglycerols in Mass Spectrometry Analysis

Analytical Quality by Design Method Development for Vaccine Characterization

Geurink, Lars

2022

• Download full text (pdf) of Analytical Quality by Design Method Development for Vaccine Characterization

Comprehensive Peak Characterization (CPC) in Untargeted LC-MS Analysis

Pirttilä, Kristian; Balgoma, David; Rainer, Johannes; Pettersson, Curt et al.

Part of Metabolites, 2022

• DOI for Comprehensive Peak Characterization (CPC) in Untargeted LC-MS Analysis
• Download full text (pdf) of Comprehensive Peak Characterization (CPC) in Untargeted LC-MS Analysis

Concentration of carprofen in the milk of lactating bitches after cesarean section and during inflammatory conditions

Ferrari, Desiree; Lundgren, Sandra; Holmberg, Johanna; Edner, Anna et al.

Part of Theriogenology, p. 59-68, 2022

• DOI for Concentration of carprofen in the milk of lactating bitches after cesarean section and during inflammatory conditions

Developing reactive oxygen species-sensitive cellulose nanofibers for chronic wound care

Palo Nieto, Carlos; Blasi Romero, Anna; Balgoma, David; Hedeland, Mikael et al.

2022

Development and Validation of a Quantitative UHPLC-MS-MS Method for the Determination of Alpha-Chloralose in Feline Blood and Application on Blood Samples Collected from Cats with Symptoms of Alpha-Chloralose Poisoning

Windahl, Ulrika; Lundgren, Sandra; Sprycha, Margareta; Tegner, Cecilia et al.

Part of Journal of Analytical Toxicology, p. 651-657, 2022

• DOI for Development and Validation of a Quantitative UHPLC-MS-MS Method for the Determination of Alpha-Chloralose in Feline Blood and Application on Blood Samples Collected from Cats with Symptoms of Alpha-Chloralose Poisoning
• Download full text (pdf) of Development and Validation of a Quantitative UHPLC-MS-MS Method for the Determination of Alpha-Chloralose in Feline Blood and Application on Blood Samples Collected from Cats with Symptoms of Alpha-Chloralose Poisoning

Development of analytical methods for the determination of the small molecule component of complex biological systems

Pirttilä, Kristian

2022

• Download full text (pdf) of Development of analytical methods for the determination of the small molecule component of complex biological systems

Investigation of neomycin biodegradation conditions using ericoid mycorrhizal and white rot fungal species

Stenholm, Åke; Hedeland, Mikael; Pettersson, Curt

Part of BMC Biotechnology, 2022

• DOI for Investigation of neomycin biodegradation conditions using ericoid mycorrhizal and white rot fungal species
• Download full text (pdf) of Investigation of neomycin biodegradation conditions using ericoid mycorrhizal and white rot fungal species

Method development for mono- and disaccharides monitoring in cell culture medium by capillary and microchip electrophoresis

van der Burg, Debbie; Josefsson, Leila; Mikkonen, Saara; Chotteau, Veronique et al.

Part of Electrophoresis, p. 922-929, 2022

• DOI for Method development for mono- and disaccharides monitoring in cell culture medium by capillary and microchip electrophoresis
• Download full text (pdf) of Method development for mono- and disaccharides monitoring in cell culture medium by capillary and microchip electrophoresis

Neomycin removal using the white rot fungus Trametes versicolor

Stenholm, Åke; Hedeland, Mikael; Pettersson, Curt

Part of Journal of Environmental Science and Health. Part A, p. 436-447, 2022

• DOI for Neomycin removal using the white rot fungus Trametes versicolor
• Download full text (pdf) of Neomycin removal using the white rot fungus Trametes versicolor

Oceanographic setting influences the prokaryotic community and metabolome in deep-sea sponges

Steffen, Karin; Indraningrat, Anak Agung Gede; Erngren, Ida; Haglöf, Jakob et al.

Part of Scientific Reports, 2022

• DOI for Oceanographic setting influences the prokaryotic community and metabolome in deep-sea sponges
• Download full text (pdf) of Oceanographic setting influences the prokaryotic community and metabolome in deep-sea sponges

On the introduction of reactive oxygen species-sensitive linkers onto cellulose nanofibrils: Towards advanced wound healing solutions.

Palo-Nieto, Carlos; Blasi Romero, Anna; Balgoma, David; Strömme, Maria et al.

2022

Oogenesis and lipid metabolism in the deep-sea sponge Phakellia ventilabrum (Linnaeus, 1767)

Koutsouveli, Vasiliki; Balgoma, David; Checa, Antonio; Hedeland, Mikael et al.

Part of Scientific Reports, 2022

• DOI for Oogenesis and lipid metabolism in the deep-sea sponge Phakellia ventilabrum (Linnaeus, 1767)
• Download full text (pdf) of Oogenesis and lipid metabolism in the deep-sea sponge Phakellia ventilabrum (Linnaeus, 1767)

Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding

Balgoma, David; Kullenberg, Fredrik; Peters, Karsten; Dahlgren, David et al.

Part of Metabolites, 2022

• DOI for Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding
• Download full text (pdf) of Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding

Plasma atropine concentrations associated with decreased intestinal motility in horses

Ekstrand, Carl; Michanek, Peter; Gehring, Ronette; Sundell, Anna et al.

Part of Frontiers in Veterinary Science, 2022

• DOI for Plasma atropine concentrations associated with decreased intestinal motility in horses
• Download full text (pdf) of Plasma atropine concentrations associated with decreased intestinal motility in horses

Protein mapping of peanut extract with capillary electrophoresis

Villemet, Loic; Cuchet, Aurelien; Desvignes, Christophe; Sänger van de Griend, Catharina

Part of Electrophoresis, p. 1027-1034, 2022

• DOI for Protein mapping of peanut extract with capillary electrophoresis
• Download full text (pdf) of Protein mapping of peanut extract with capillary electrophoresis

Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival

Sennefelt Nyman, Sofi; Ahlström, Håkan; Dimopoulou, Angeliki; Dahlgren, David et al.

Part of BMJ Open, 2022

• DOI for Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival
• Download full text (pdf) of Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival

The optimization of a manual dissolution method and its equivalence to automated dissolution

Cicek, Diana

2022

• Download full text (pdf) of The optimization of a manual dissolution method and its equivalence to automated dissolution

A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma

Nylund, Patrick; Atienza Párraga, Alba; Haglöf, Jakob; De Bruyne, Elke et al.

Part of Cell Death and Disease, 2021

• DOI for A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma
• Download full text (pdf) of A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma

A high-throughput method for screening of protein binding behavior of multimodal anionic exchange ligands

Avedis, Ani

2021

• Download full text (pdf) of A high-throughput method for screening of protein binding behavior of multimodal anionic exchange ligands

Analytical method development in liquid chromatography- mass spectrometry based metabolomics

Erngren, Ida

2021

• Download full text (pdf) of Analytical method development in liquid chromatography- mass spectrometry based metabolomics

Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death

Balgoma, David; Kullenberg, Fredrik; Calitz, Carlemi; Kopsida, Maria et al.

Part of Cells, 2021

• DOI for Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death
• Download full text (pdf) of Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death

Automated Sequential Analysis of Hydrophilic and Lipophilic Fractions of Biological Samples: Increasing Single-Injection Chemical Coverage in Untargeted Metabolomics

Pirttilä, Kristian; Laurell, Göran; Pettersson, Curt; Hedeland, Mikael

Part of Metabolites, 2021

• DOI for Automated Sequential Analysis of Hydrophilic and Lipophilic Fractions of Biological Samples: Increasing Single-Injection Chemical Coverage in Untargeted Metabolomics
• Download full text (pdf) of Automated Sequential Analysis of Hydrophilic and Lipophilic Fractions of Biological Samples: Increasing Single-Injection Chemical Coverage in Untargeted Metabolomics

Dimethylarginines correlate to common carotid artery wall layer dimensions and cardiovascular risk factors in pregnant women with/without preeclampsia: A group comparative study

Akhter, Tansim; Wikström, Gerhard; Larsson, Marita; Bondesson, Ulf et al.

Part of European Journal of Obstetrics, Gynecology, and Reproductive Biology, p. 288-293, 2021

• DOI for Dimethylarginines correlate to common carotid artery wall layer dimensions and cardiovascular risk factors in pregnant women with/without preeclampsia: A group comparative study
• Download full text (pdf) of Dimethylarginines correlate to common carotid artery wall layer dimensions and cardiovascular risk factors in pregnant women with/without preeclampsia: A group comparative study

Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats

Dahlgren, David; Olander, Tobias; Sjöblom, Markus; Hedeland, Mikael et al.

Part of Acta Pharmaceutica Sinica B, p. 1667-1675, 2021

• DOI for Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats
• Download full text (pdf) of Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats

Etherglycerophospholipids and ferroptosis: structure, regulation, and location

Balgoma, David; Hedeland, Mikael

Part of Trends in endocrinology and metabolism, p. 960-962, 2021

• DOI for Etherglycerophospholipids and ferroptosis: structure, regulation, and location
• Download full text (pdf) of Etherglycerophospholipids and ferroptosis: structure, regulation, and location

Four-step approach to efficiently develop capillary gel electrophoresis methods for viral vaccine protein analysis

Geurink, Lars; van Tricht, Ewoud; Dudink, Justin; Pajic, Bojana et al.

Part of Electrophoresis, p. 10-18, 2021

• DOI for Four-step approach to efficiently develop capillary gel electrophoresis methods for viral vaccine protein analysis

Improved sensitivity in hydrophilic interaction liquid chromatography-electrospray-mass spectrometry after removal of sodium and potassium ions from biological samples

Erngren, Ida; Nestor, Marika; Pettersson, Curt; Hedeland, Mikael

Part of Metabolites, 2021

• DOI for Improved sensitivity in hydrophilic interaction liquid chromatography-electrospray-mass spectrometry after removal of sodium and potassium ions from biological samples
• Download full text (pdf) of Improved sensitivity in hydrophilic interaction liquid chromatography-electrospray-mass spectrometry after removal of sodium and potassium ions from biological samples

In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma

Kullenberg, Fredrik; Degerstedt, Oliver; Calitz, Carlemi; Pavlovic, Natasa et al.

Part of Cells, 2021

• DOI for In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma
• Download full text (pdf) of In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma

Investigation of Equine In Vivo and In Vitro Derived Metabolites of the Selective Androgen Receptor Modulator (SARM) ACP-105 for Improved Doping Control

Nilsson Broberg, Malin; Knych, Heather; Bondesson, Ulf; Pettersson, Curt et al.

Part of Metabolites, 2021

• DOI for Investigation of Equine In Vivo and In Vitro Derived Metabolites of the Selective Androgen Receptor Modulator (SARM) ACP-105 for Improved Doping Control
• Download full text (pdf) of Investigation of Equine In Vivo and In Vitro Derived Metabolites of the Selective Androgen Receptor Modulator (SARM) ACP-105 for Improved Doping Control

Modification and validation of the Endopep-mass spectrometry method for botulinum neurotoxin detection in liver samples with application to samples collected during animal botulism outbreaks

Tevell Åberg, Annica; Karlsson, Ida; Hedeland, Mikael

Part of Analytical and Bioanalytical Chemistry, p. 345-354, 2021

• DOI for Modification and validation of the Endopep-mass spectrometry method for botulinum neurotoxin detection in liver samples with application to samples collected during animal botulism outbreaks
• Download full text (pdf) of Modification and validation of the Endopep-mass spectrometry method for botulinum neurotoxin detection in liver samples with application to samples collected during animal botulism outbreaks

Prednisolone in Dogs: Plasma Exposure and White Blood Cell Response

Ekstrand, Carl; Pettersson, Helena; Gehring, Ronette; Hedeland, Mikael et al.

Part of Frontiers in Veterinary Science, 2021

• DOI for Prednisolone in Dogs: Plasma Exposure and White Blood Cell Response
• Download full text (pdf) of Prednisolone in Dogs: Plasma Exposure and White Blood Cell Response

Quantification of circulating CD19 CAR-T cells in peripheral blood for implementation in routine diagnostics

Sjölund, Hanna

2021

• Download full text (pdf) of Quantification of circulating CD19 CAR-T cells in peripheral blood for implementation in routine diagnostics