Amphiphilic Drugs in Microgels (Completed project)
Development of release models that contribute to the development of novel release systems for amphiphilic drugs.
Beskrivning
Research scientist: Yassir Al-Tikriti, MSc
Principal Investigator: Professor Per Hansson, Department of Medicinal Chemistry, Uppsala University
Scientific and industrial context. Amphiphilic drug molecules is an important group of active substances which are commonly used in cancer therapy, as antidepressants and antihypertensive agents. These molecules have properties in common with regular micelle-forming surfactants but the relationships between their molecular structure and self-assembling properties are not well understood. Polyelectrolyte microgels are interesting as carriers of amphiphilic drugs. To realize their potential as drug delivery systems it is necessary to study the basic principles governing the drug loading and release properties.
Aim. To relate the microstructure and thermodynamic stability of drug self-assemblies in microgels to the molecular properties of drugs and microgel networks and to the mechanisms and kinetics of release under physiological conditions.
Outcome. Release models that contribute to the development of novel release systems for amphiphilic drugs.