Novel In Vitro Models for Subcutaneous Administration of Drugs: Transport Properties
Developing an in vitro method that can be used to predict the rate of drug absorption in humans after subcutaneous administration.
Research scientist: Julia Parlow. MSc
Principal investigator: Professor Per Hansson, Department of Medicinal Chemistry, Uppsala University
Scientific and industrial context. Injection into the tissue under the skin is an attractive administration route for many biomolecular drugs available as a result of recent biotechnological progress. The development of drug formulations for this route is challenged by the difficulty to predict the fate of drug formulations after injection due to the complexity of the subcutaneous (SC) environment, the large variability between patients and biomolecular drug properties.
Aim. The aim is to develop methods to study the transport of drug molecules in biorelevant synthetic models of human SC extracellular matrix, and to use the methods to clarify the key factors governing the transport with respect to interaction with the constituents of the matrix and the interstitial fluid.
Outcome. An in vitro method that can be used to predict the rate of drug absorption in humans after subcutaneous administration.