In Vitro Methods for Enhanced Understanding of Peptide Transport in Subcutaneous Tissue

Research scientist: Yassir Al-Tikriti, PostDoc
Principal Investigator: Professor Per Hansson, Department of Medicinal Chemistry, Uppsala University

Scientific and industrial context. In contemporary pharmaceutical research, there is a growing emphasis on in vitro methods for predicting drug absorption after subcutaneous administration. These methods offer a more cost-effective and ethical approach compared to in vivo animal studies. My research focuses on developing and implementing experimental methods to study the transport of peptide drugs within a synthetic model replicating the extracellular matrix of subcutaneous tissue.

Aim. To generate data that aids in modeling drug absorption after in vivo administration. The focus is on identifying specific molecular properties that influence the diffusion and transport of peptide drugs within subcutaneous tissue.

Outcome. Attain a deeper understanding of molecular factors influencing peptide drug behavior within subcutaneous tissue, facilitating the development of pharmaceutical products with high bioavailability and low patient variability.