Physiochemical Aspects of Subcutaneous Administration of Drugs (Completed project)
Providing a basis for the development of novel in vitro methods to model the behaviour of subcutaneously administrated pharmaceutical products.
Research scientist: Marcus Wanselius, MSc
Principal investigator: Professor Per Hansson, Department of Medicinal Chemistry, Uppsala University
Scientific and industrial context. Subcutaneous administration of drug formulations is an attractive alternative for the growing amount of active pharmaceutical ingredients (APIs) with low oral bioavailability. Therefore, it is important to investigate and understand the interactions between different drug formulations and the subcutaneous adipose tissue (hypodermis).
Aim. The aim of the project is to provide a mechanistic understanding of how APIs (especially biologics) and excipients in drug formulations interact with the components of the extracellular matrix in the hypodermis.A Further aim is to develop new formulation principles resulting in sustained release and high bioavailability of the APIs.
Out-come. The investigation will provide a basis for the development of novel in vitro methods to model the behaviour of subcutaneously administrated pharmaceutical products.