Oommen Vargheses grupp

Physically and Chemically Crosslinked Hyaluronic Acid-Based Hydrogels Differentially Promote Axonal Outgrowth from Neural Tissue Cultures

Bajic, Andrej; Andersson, Brittmarie; Ossinger, Alexander; Tavakoli, Shima et al.

Ingår i Biomimetics, 2024

• DOI för Physically and Chemically Crosslinked Hyaluronic Acid-Based Hydrogels Differentially Promote Axonal Outgrowth from Neural Tissue Cultures
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A quality by design approach to optimise disulfide-linked hyaluronic acid hydrogels

Ranamalla, Saketh Reddy; Tavakoli, Shima; Porfire, Alina Silvia; Tefas, Lucia Ruxandra et al.

Ingår i Carbohydrate Polymers, 2024

• DOI för A quality by design approach to optimise disulfide-linked hyaluronic acid hydrogels
• Ladda ner fulltext (pdf) av A quality by design approach to optimise disulfide-linked hyaluronic acid hydrogels

Fine-tuning Dynamic Cross-linking for Enhanced 3D Bioprinting of Hyaluronic Acid Hydrogels

Tavakoli, Shima; Krishnan, Nithiyanandan; Mokhtari, Hamidreza; Oommen, Oommen P. et al.

Ingår i Advanced Functional Materials, 2024

• DOI för Fine-tuning Dynamic Cross-linking for Enhanced 3D Bioprinting of Hyaluronic Acid Hydrogels
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Advances in Intracellular and On-Surface Polymerization in Living Cells: Implications for Nanobiomedicines

Laskar, Partha; Varghese, Oommen P.; Shastri, V. Prasad

Ingår i Advanced NanoBiomed Research, 2023

• DOI för Advances in Intracellular and On-Surface Polymerization in Living Cells: Implications for Nanobiomedicines
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Biomimetic polyelectrolyte coating of stem cells suppresses thrombotic activation and enhances its survival and function

Rangasami, Vignesh K.; Asawa, Kenta; Teramura, Yuji; Le Blanc, Katrina et al.

Ingår i Biomaterials Advances, 2023

• DOI för Biomimetic polyelectrolyte coating of stem cells suppresses thrombotic activation and enhances its survival and function
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Unveiling extracellular matrix assembly: Insights and approaches through bioorthogonal chemistry

Tavakoli, Shima; Evans, Austin; Oommen, Oommen P.; Creemers, Laura et al.

Ingår i MATERIALS TODAY BIO, 2023

• DOI för Unveiling extracellular matrix assembly: Insights and approaches through bioorthogonal chemistry
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Heparin-Derived Theranostic Nanoprobes Overcome the Blood-Brain Barrier and Target Glioma in Murine Model

Samanta, Sumanta; Le Joncour, Vadim; Wegrzyniak, Olivia; Rangasami, Vignesh K. et al.

Ingår i Advanced Therapeutics, 2022

• DOI för Heparin-Derived Theranostic Nanoprobes Overcome the Blood-Brain Barrier and Target Glioma in Murine Model
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Interpenetrating gallol functionalized tissue adhesive hyaluronic acid hydrogel polarizes macrophages to an immunosuppressive phenotype

Samanta, Sumanta; Rangasami, Vignesh K.; Sarlus, Heela; Samal, Jay R. K. et al.

Ingår i Acta Biomaterialia, s. 36-48, 2022

• DOI för Interpenetrating gallol functionalized tissue adhesive hyaluronic acid hydrogel polarizes macrophages to an immunosuppressive phenotype
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Dynamic covalent crosslinked hyaluronic acid hydrogels and nanomaterials for biomedical applications

Wang, Shujiang; Tavakoli, Shima; Parvathaneni, Rohith Pavan; Nawale, Ganesh N. et al.

Ingår i Biomaterials Science, s. 6399-6412, 2022

• DOI för Dynamic covalent crosslinked hyaluronic acid hydrogels and nanomaterials for biomedical applications
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Effect of the Addition Frequency of 5-Azacytidine in Both Micro- and Macroscale Cultures

Kadekar, Sandeep; Barbe, Laurent; Stoddart, Martin; Varghese, Oommen P. et al.

Ingår i Cellular and Molecular Bioengineering, s. 121-130, 2021

• DOI för Effect of the Addition Frequency of 5-Azacytidine in Both Micro- and Macroscale Cultures
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Redox responsive Pluronic micelle mediated delivery of functional siRNA: a modular nano-assembly for targeted delivery

Kadekar, Sandeep; Nawale, Ganesh N.; Rangasami, Vignesh K.; Le Joncour, Vadim et al.

Ingår i Biomaterials Science, s. 3939-3944, 2021

• DOI för Redox responsive Pluronic micelle mediated delivery of functional siRNA: a modular nano-assembly for targeted delivery
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Discrepancies on the Role of Oxygen Gradient and Culture Condition on Mesenchymal Stem Cell Fate

Samal, Jay R. K.; Rangasami, Vignesh K.; Samanta, Sumanta; Varghese, Oommen P. et al.

Ingår i Advanced Healthcare Materials, 2021

• DOI för Discrepancies on the Role of Oxygen Gradient and Culture Condition on Mesenchymal Stem Cell Fate
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An unexpected role of an extra phenolic hydroxyl on the chemical reactivity and bioactivity of catechol or gallol modified hyaluronic acid hydrogels

Samanta, Sumanta; Rangasami, Vignesh K.; Murugan, N. Arul; Parihar, Vijay Singh et al.

Ingår i Polymer Chemistry, s. 2987-2991, 2021

• DOI för An unexpected role of an extra phenolic hydroxyl on the chemical reactivity and bioactivity of catechol or gallol modified hyaluronic acid hydrogels
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PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications

Carter, Sarah-Sophia; Atif, Abdul Raouf; Kadekar, Sandeep; Lanekoff, Ingela et al.

Ingår i Organs-on-a-Chip, 2020

• DOI för PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications
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Modulating thiol pK_a promotes disulfide formation at physiological pH: An elegant strategy to design disulfide cross-linked hyaluronic acid hydrogels

Bermejo-Velasco, Daniel; Azémar, Alice; Oommen, Oommen P.; Hilborn, Jöns et al.

Ingår i Biomacromolecules, s. 1412-1420, 2019

• DOI för Modulating thiol pK_a promotes disulfide formation at physiological pH: An elegant strategy to design disulfide cross-linked hyaluronic acid hydrogels

First Aldol Cross-Linked Hyaluronic Acid Hydrogel: Fast and Hydrolytically Stable Hydrogel with Tissue Adhesive Properties

Bermejo-Velasco, Daniel; Kadekar, Sandeep; Tavares da Costa, Marcus Vinicius; Oommen, Oommen P. et al.

Ingår i ACS Applied Materials and Interfaces, s. 38232-38239, 2019

• DOI för First Aldol Cross-Linked Hyaluronic Acid Hydrogel: Fast and Hydrolytically Stable Hydrogel with Tissue Adhesive Properties

MicroRNA detection based on duplex-specific nuclease-assisted target recycling and gold nanoparticle/graphene oxide nanocomposite-mediated electrocatalytic amplification

Han, Yuanyuan; Qiu, Zhen; Nawale, Ganesh N.; Varghese, Oommen P. et al.

Ingår i Biosensors & bioelectronics, s. 188-193, 2019

• DOI för MicroRNA detection based on duplex-specific nuclease-assisted target recycling and gold nanoparticle/graphene oxide nanocomposite-mediated electrocatalytic amplification

Synthetic design of asymmetric miRNA with engineered 3′-overhang to improve strand selection

Kadekar, Sandeep; Nawale, Ganesh N.; Karlsson, Kira; Ålander, Cecilia et al.

Ingår i Molecular Therapy Nucleic Acids, s. 597-604, 2019

• DOI för Synthetic design of asymmetric miRNA with engineered 3′-overhang to improve strand selection
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A turn-on fluorescent GFP chromophore analog for highly selective and efficient detection of H2S in aqueous and in living cells

Mittapelli, Lavanya L.; Nawale, Ganesh N.; Gholap, Sachin P.; Varghese, Oommen P. et al.

Ingår i Sensors and actuators. B, Chemical, 2019

• DOI för A turn-on fluorescent GFP chromophore analog for highly selective and efficient detection of H2S in aqueous and in living cells

4 '-Guanidinium-modified siRNA: a molecular tool to control RNAi activity through RISC priming and selective antisense strand loading

Nawale, Ganesh N.; Bahadorikhalili, Saeed; Sengupta, Pallabi; Kadekar, Sandeep et al.

Ingår i Chemical Communications, s. 9112-9115, 2019

• DOI för 4 '-Guanidinium-modified siRNA: a molecular tool to control RNAi activity through RISC priming and selective antisense strand loading
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Innovative strategy for 3D transfection of primary human stem cells with BMP-2 expressing plasmid DNA: A clinically translatable strategy for ex vivogene therapy

Paidikondala, Maruthibabu; Kadekar, Sandeep; Varghese, Oommen P.

Ingår i International Journal of Molecular Sciences, 2019

• DOI för Innovative strategy for 3D transfection of primary human stem cells with BMP-2 expressing plasmid DNA: A clinically translatable strategy for ex vivogene therapy
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Insights into siRNA Transfection in Suspension: Efficient Gene Silencing in Human Mesenchymal Stem Cells Encapsulated in Hyaluronic Acid Hydrogel

Paidikondala, Maruthibabu; Nawale, Ganesh N.; Varghese, Oommen P.

Ingår i Biomacromolecules, s. 1317-1324, 2019

• DOI för Insights into siRNA Transfection in Suspension: Efficient Gene Silencing in Human Mesenchymal Stem Cells Encapsulated in Hyaluronic Acid Hydrogel

An Unexpected Role of Hyaluronic Acid in Trafficking siRNA Across the Cellular Barrier: The First Biomimetic, Anionic, Non-Viral Transfection Method

Paidikondala, Maruthibabu; Rangasami, Vignesh Kumar; Nawale, Ganesh N.; Casalini, Tommaso et al.

Ingår i Angewandte Chemie International Edition, s. 2815-2819, 2019

• DOI för An Unexpected Role of Hyaluronic Acid in Trafficking siRNA Across the Cellular Barrier: The First Biomimetic, Anionic, Non-Viral Transfection Method

Impact of Hydrogel Cross-Linking Chemistry on the in Vitro and in VivoBioactivity of Recombinant Human Bone Morphogenetic Protein-2

Paidikondala, Maruthibabu; Wang, Shujiang; Hilborn, Jöns; Larsson, Sune et al.

Ingår i ACS Applied Bio Materials, 2019

• DOI för Impact of Hydrogel Cross-Linking Chemistry on the in Vitro and in VivoBioactivity of Recombinant Human Bone Morphogenetic Protein-2

Influence of ions to modulate hydrazone and oxime reaction kinetics to obtain dynamically cross-linked hyaluronic acid hydrogels

Wang, Shujiang; Nawale, Ganesh N.; Oommen, Oommen P.; Hilborn, Jöns et al.

Ingår i Polymer Chemistry, s. 4322-4327, 2019

• DOI för Influence of ions to modulate hydrazone and oxime reaction kinetics to obtain dynamically cross-linked hyaluronic acid hydrogels
• Ladda ner fulltext (pdf) av Influence of ions to modulate hydrazone and oxime reaction kinetics to obtain dynamically cross-linked hyaluronic acid hydrogels

Thiazolidine chemistry revisited: a fast, efficient and stable click-type reaction at physiological pH

Bermejo-Velasco, Daniel; Nawale, Ganesh N.; Oommen, Oommen P.; Hilborn, Jöns et al.

Ingår i Chemical Communications, s. 12507-12510, 2018

• DOI för Thiazolidine chemistry revisited: a fast, efficient and stable click-type reaction at physiological pH
• Ladda ner fulltext (pdf) av Thiazolidine chemistry revisited: a fast, efficient and stable click-type reaction at physiological pH

Bi-directional cell-pericellular matrix interactions direct stem cell fate

Ferreira, Silvia A; Motwani, Meghna S; Faull, Peter A; Seymour, Alexis J et al.

Ingår i Nature Communications, 2018

• DOI för Bi-directional cell-pericellular matrix interactions direct stem cell fate
• Ladda ner fulltext (pdf) av Bi-directional cell-pericellular matrix interactions direct stem cell fate

Saline Accelerates Oxime Reaction with Aldehyde and Keto Substrates at Physiological pH

Wang, Shujiang; Nawale, Ganesh N.; Kadekar, Sandeep; Oommen, Oommen P. et al.

Ingår i Scientific Reports, 2018

• DOI för Saline Accelerates Oxime Reaction with Aldehyde and Keto Substrates at Physiological pH
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Synthetic design of growth factor sequestering extracellular matrix mimetic hydrogel for promoting in vivo bone formation

Yan, Hongji; Casalini, Tommaso; Hulsart Billström, Gry; Wang, Shujiang et al.

Ingår i Biomaterials, s. 190-202, 2018

• DOI för Synthetic design of growth factor sequestering extracellular matrix mimetic hydrogel for promoting in vivo bone formation

Injectable and thermoresponsive pericardial matrix derived conductive scaffold for cardiac tissue engineering

Roshanbinfar, Kaveh; Hilborn, Jöns; Varghese, Oommen P.; Oommen, Oommen P.

Ingår i RSC Advances, s. 31980-31988, 2017

• DOI för Injectable and thermoresponsive pericardial matrix derived conductive scaffold for cardiac tissue engineering
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Host cell recruitment patterns by bone morphogenetic protein-2 releasing hyaluronic acid hydrogels in a mouse subcutaneous environment

Todeschi, Maria R.; El Backly, Rania M.; Varghese, Oommen P.; Hilborn, Jöns et al.

Ingår i Regenerative Medicine, s. 525-539, 2017

• DOI för Host cell recruitment patterns by bone morphogenetic protein-2 releasing hyaluronic acid hydrogels in a mouse subcutaneous environment

Chondroitin sulfate coated gold nanoparticles: a new strategy to resolve multidrug resistance and thromboinflammation

Gurav, Deepanjali; Varghese, Oommen P.; Hamad, Osama A.; Nilsson, Bo et al.

Ingår i Chemical Communications, s. 966-969, 2016

• DOI för Chondroitin sulfate coated gold nanoparticles: a new strategy to resolve multidrug resistance and thromboinflammation

Multifunctional Hyaluronic Acid and Chondroitin Sulfate Nanoparticles: Impact of Glycosaminoglycan Presentation on Receptor Mediated Cellular Uptake and Immune Activation

Oommen, Oommen Podiyan; Duehrkop, Claudia; Nilsson, Bo; Hilborn, Jöns et al.

Ingår i ACS Applied Materials and Interfaces, s. 20614-20624, 2016

• DOI för Multifunctional Hyaluronic Acid and Chondroitin Sulfate Nanoparticles: Impact of Glycosaminoglycan Presentation on Receptor Mediated Cellular Uptake and Immune Activation

Chondroitin sulfate derived theranostic nanoparticles for targeted drug delivery

Varghese, Oommen P.; Liu, Jianping; Sundaram, Karthi; Hilborn, Jöns et al.

Ingår i Biomaterials Science, s. 1310-1313, 2016

• DOI för Chondroitin sulfate derived theranostic nanoparticles for targeted drug delivery

2 '-N-Guanidino, 4 '-C-ethylene bridged thymidine (GENA-T) modified oligonucleotide exhibits triplex formation with excellent enzymatic stability

Barman, Jharna; Gurav, Deepanjali; Oommen, Oommen Podiyan; Varghese, Oommen P.

Ingår i RSC Advances, s. 12257-12260, 2015

• DOI för 2 '-N-Guanidino, 4 '-C-ethylene bridged thymidine (GENA-T) modified oligonucleotide exhibits triplex formation with excellent enzymatic stability

Insights into the Mechanism and Catalysis of Oxime Coupling Chemistry at Physiological pH

Wang, Shujiang; Gurav, Deepanjali; Oommen, Oommen Podiyan; Varghese, Oommen P

Ingår i Chemistry - A European Journal, s. 5980-5985, 2015

• DOI för Insights into the Mechanism and Catalysis of Oxime Coupling Chemistry at Physiological pH

Chondroitin Sulfate-Coated DNA-Nanoplexes Enhance Transfection Efficiency by Controlling Plasmid Release from Endosomes: A New Insight into Modulating Nonviral Gene Transfection

Yan, Hongji; Podiyan, Oommen; Yu, Di; Hilborn, Jöns et al.

Ingår i Advanced Functional Materials, s. 3907-3915, 2015

• DOI för Chondroitin Sulfate-Coated DNA-Nanoplexes Enhance Transfection Efficiency by Controlling Plasmid Release from Endosomes: A New Insight into Modulating Nonviral Gene Transfection

Tailored Doxorubicin-Hyaluronan Conjugate as a Potent Anticancer Glyco-Drug: An Alternative to Prodrug Approach

Podiyan, Oommen; Garousi, Javad; Sloff, Marije; Varghese, Oommen

Ingår i Macromolecular Bioscience, s. 327-333, 2014

• DOI för Tailored Doxorubicin-Hyaluronan Conjugate as a Potent Anticancer Glyco-Drug: An Alternative to Prodrug Approach

Cell type and transfection reagent-dependent effects on viability, cell content, cell cycle and inflammation of RNAi in human primary mesenchymal cells

Yang, Hsiao-yin; Vonk, Lucienne A.; Licht, Ruud; van Boxtel, Antonetta M. G. et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 35-44, 2014

• DOI för Cell type and transfection reagent-dependent effects on viability, cell content, cell cycle and inflammation of RNAi in human primary mesenchymal cells

Smart Design of Stable Extracellular Matrix Mimetic Hydrogel: Synthesis, Characterization, and In Vitro and In Vivo Evaluation for Tissue Engineering

Oommen, Oommen P.; Wang, Shujiang; Kisiel, Marta; Sloff, Marije et al.

Ingår i Advanced Functional Materials, s. 1273-1280, 2013

• DOI för Smart Design of Stable Extracellular Matrix Mimetic Hydrogel: Synthesis, Characterization, and In Vitro and In Vivo Evaluation for Tissue Engineering

PLGA/PEG-hydrogel composite scaffolds with controllable mechanical properties

Rahman, Cheryl V.; Kuhn, Gisela; White, Lisa J.; Kirby, Giles T. S. et al.

Ingår i Journal of Biomedical Materials Research. Part B - Applied biomaterials, s. 648-655, 2013

• DOI för PLGA/PEG-hydrogel composite scaffolds with controllable mechanical properties

Mild and Efficient Strategy for Site-Selective Aldehyde Modification of Glycosaminoglycans: Tailoring Hydrogels with Tunable Release of Growth Factor

Wang, Shujiang; Oommen, Oommen P.; Yan, Hongji; Varghese, Oommen P.

Ingår i Biomacromolecules, s. 2427-2432, 2013

• DOI för Mild and Efficient Strategy for Site-Selective Aldehyde Modification of Glycosaminoglycans: Tailoring Hydrogels with Tunable Release of Growth Factor

Critical assessment of rhBMP-2 mediated bone induction: An in vitro and in vivo evaluation.

Kisiel, Marta; Ventura, Manuela; Podiyan, Oommen; George, Anu et al.

Ingår i Journal of Controlled Release, s. 646-653, 2012

• DOI för Critical assessment of rhBMP-2 mediated bone induction: An in vitro and in vivo evaluation.

Minimally invasive mandibular bone augmentation using injectable hydrogels

Martinez-Sanz, Elena; Varghese, Oommen; Kisiel, Marta; Engstrand, Thomas et al.

Ingår i Journal of Tissue Engineering and Regenerative Medicine, 2012

• DOI för Minimally invasive mandibular bone augmentation using injectable hydrogels

Injectable hyaluronic acid hydrogel for bone tissue engineering

Varghese, Oommen P.; Podiyan, Oommen; Wang, S; Kisiel, Marta et al.

Ingår i European Cells and Materials, s. 2, 2012

Bone reservoir: Injectable hyaluronic acid hydrogel for minimal invasive bone augmentation

Martinez-Sanz, Elena; Ossipov, Dmitri A.; Hilborn, Jöns; Larsson, Sune et al.

Ingår i Journal of Controlled Release, s. 232-240, 2011

• DOI för Bone reservoir: Injectable hyaluronic acid hydrogel for minimal invasive bone augmentation

Functionalization of Hyaluronic Acid with Chemoselective Groups via a Disulfide-Based Protection Strategy for In Situ Formation of Mechanically Stable Hydrogels

Ossipov, Dmitri A.; Piskounova, Sonya; Varghese, Oommen P.; Hilborn, Jöns

Ingår i Biomacromolecules, s. 2247-2254, 2010

• DOI för Functionalization of Hyaluronic Acid with Chemoselective Groups via a Disulfide-Based Protection Strategy for In Situ Formation of Mechanically Stable Hydrogels

Modular approach to functional hyaluronic acid hydrogels using orthogonal chemical reactions

Ossipov, Dmitri A.; Yang, Xia; Varghese, Oommen; Kootala, Sujit et al.

Ingår i Chemical Communications, s. 8368-8370, 2010

• DOI för Modular approach to functional hyaluronic acid hydrogels using orthogonal chemical reactions

Synthesis of Guanidinium-Modified Hyaluronic Acid Hydrogel

Varghese, Oommen P.; Kisiel, Marta; Martinez-Sanz, Elena; Ossipov, Dmitri A. et al.

Ingår i Macromolecular rapid communications, s. 1175-1180, 2010

• DOI för Synthesis of Guanidinium-Modified Hyaluronic Acid Hydrogel

In Situ Cross-Linkable High Molecular Weight Hyaluronan−Bisphosphonate Conjugate for Localized Delivery and Cell-Specific Targeting: A Hydrogel Linked Prodrug Approach

Varghese, Oommen P.; Sun, Weilun; Hilborn, Jöns; Ossipov, Dmitri A.

Ingår i Journal of the American Chemical Society, s. 8781-8783, 2009

• DOI för In Situ Cross-Linkable High Molecular Weight Hyaluronan−Bisphosphonate Conjugate for Localized Delivery and Cell-Specific Targeting: A Hydrogel Linked Prodrug Approach