Bryndis Birnir

Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

Cotman, Andrej Emanuel; Durcik, Martina; Tiz, Davide Benedetto; Fulgheri, Federica et al.

Ingår i Journal of Medicinal Chemistry, s. 1380-1425, 2023

• DOI för Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa
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Endogenous Levels of Gamma Amino-Butyric Acid Are Correlated to Glutamic-Acid Decarboxylase Antibody Levels in Type 1 Diabetes

Hill, Henrik; Elksnis, Andris; Lundkvist, Per; Ubhayasekera, Kumari et al.

Ingår i Biomedicines, 2022

• DOI för Endogenous Levels of Gamma Amino-Butyric Acid Are Correlated to Glutamic-Acid Decarboxylase Antibody Levels in Type 1 Diabetes
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ZEB2 haploinsufficient Mowat-Wilson syndrome induced pluripotent stem cells show disrupted GABAergic transcriptional regulation and function

Schuster, Jens; Klar, Joakim; Khalfallah, Ayda; Laan, Loora et al.

Ingår i Frontiers in Molecular Neuroscience, 2022

• DOI för ZEB2 haploinsufficient Mowat-Wilson syndrome induced pluripotent stem cells show disrupted GABAergic transcriptional regulation and function
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Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age-dependent manner, normalizes GABA-activated currents in the tg-APPSwe mouse model of Alzheimer's disease

Hammoud, Hayma; Netsyk, Olga; Tafreshiha, Atieh S.; Korol, Sergiy V. et al.

Ingår i Acta Physiologica, 2021

• DOI för Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age-dependent manner, normalizes GABA-activated currents in the tg-APPSwe mouse model of Alzheimer's disease
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Monoallelic and bi-allelic variants in NCDN cause neurodevelopmental delay, intellectual disability, and epilepsy

Fatima, Ambrin; Hoeber, Jan; Schuster, Jens; Koshimizu, Eriko et al.

Ingår i American Journal of Human Genetics, s. 739-748, 2021

• DOI för Monoallelic and bi-allelic variants in NCDN cause neurodevelopmental delay, intellectual disability, and epilepsy
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GABA(A) Receptor-Mediated Currents and Hormone mRNAs in Cells Expressing More Than One Hormone Transcript in Intact Human Pancreatic Islets

Korol, Sergiy; Jin, Zhe; Birnir, Bryndis

Ingår i International Journal of Molecular Sciences, 2020

• DOI för GABA(A) Receptor-Mediated Currents and Hormone mRNAs in Cells Expressing More Than One Hormone Transcript in Intact Human Pancreatic Islets
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Tonic GABA-activated synaptic and extrasynaptic currents in dentate gyrus granule cells and CA3 pyramidal neurons along the mouse hippocampal dorsoventral axis

Netsyk, Olga; Hammoud, Hayma; Korol, Sergiy; Jin, Zhe et al.

Ingår i Hippocampus, s. 1146-1157, 2020

• DOI för Tonic GABA-activated synaptic and extrasynaptic currents in dentate gyrus granule cells and CA3 pyramidal neurons along the mouse hippocampal dorsoventral axis
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Gunnar Flemström's legacy in intestinal bicarbonate secretion: A homage to Gunnar Flemström and his work in intestinal bicarbonate secretion

Seidler, Ursula; Nylander, Olof; Sjöblom, Markus; Birnir, Bryndis et al.

Ingår i Acta Physiologica, 2019

• DOI för Gunnar Flemström's legacy in intestinal bicarbonate secretion: A homage to Gunnar Flemström and his work in intestinal bicarbonate secretion

Transcriptomes of Dravet syndrome iPSC derived GABAergic cells reveal dysregulated pathways for chromatin remodeling and neurodevelopment

Schuster, Jens; Laan, Loora; Klar, Joakim; Jin, Zhe et al.

Ingår i Neurobiology of Disease, 2019

• DOI för Transcriptomes of Dravet syndrome iPSC derived GABAergic cells reveal dysregulated pathways for chromatin remodeling and neurodevelopment
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Interferon-gamma potentiates GABA(A) receptor-mediated inhibitory currents in rat hippocampal CA1 pyramidal neurons

Flood, Louise; Korol, Sergiy; Ekselius, Lisa; Birnir, Bryndis et al.

Ingår i Journal of Neuroimmunology, 2019

• DOI för Interferon-gamma potentiates GABA(A) receptor-mediated inhibitory currents in rat hippocampal CA1 pyramidal neurons
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Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers

Bhandage, Amol K.; Cunningham, Janet L.; Jin, Zhe; Shen, Qiujin et al.

Ingår i International Journal of Molecular Sciences, 2019

• DOI för Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers
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Ataxia in Patients With Bi-Allelic NFASC Mutations and Absence of Full-Length NF186

Kvarnung, Malin; Shahsavani, Mansoureh; Taylan, Fulya; Moslem, Mohsen et al.

Ingår i Frontiers in Genetics, 2019

• DOI för Ataxia in Patients With Bi-Allelic NFASC Mutations and Absence of Full-Length NF186
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She is in science to stay!

Birnir, Bryndis; Eliasson, L.

Ingår i Acta Physiologica, 2018

• DOI för She is in science to stay!

GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4⁺ T Cells and Is Immunosuppressive in Type 1 Diabetes

Bhandage, Amol K.; Jin, Zhe; Korol, Sergiy V.; Shen, Qiujin et al.

Ingår i EBioMedicine, s. 283-294, 2018

• DOI för GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4⁺ T Cells and Is Immunosuppressive in Type 1 Diabetes
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Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells

Korol, Sergiy V; Jin, Zhe; Jin, Yang; Bhandage, Amol K. et al.

Ingår i EBioMedicine, 2018

• DOI för Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells
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Expression of calcium release-activated and voltage-gated calcium channels genes in peripheral blood mononuclear cells is altered in pregnancy and in type 1 diabetes

Bhandage, Amol; Jin, Zhe; Korol, Sergiy V; Tafreshiha, Atieh et al.

Ingår i PLOS ONE, 2018

• DOI för Expression of calcium release-activated and voltage-gated calcium channels genes in peripheral blood mononuclear cells is altered in pregnancy and in type 1 diabetes
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Insulin enhances GABA_A receptor-mediated inhibitory currents in rat central amygdala neurons

Korol, Sergiy V.; Tafreshiha, Atieh; Bhandage, Amol K.; Birnir, Bryndis et al.

Ingår i Neuroscience Letters, s. 76-81, 2018

• DOI för Insulin enhances GABA_A receptor-mediated inhibitory currents in rat central amygdala neurons
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AMPA, NMDA and kainate glutamate receptor subunits are expressed in human peripheral blood mononuclear cells (PBMCs) where the expression of GluK4 is altered by pregnancy and GluN2D by depression in pregnant women

Bhandage, Amol K.; Jin, Zhe; Hellgren, Charlotte; Korol, Sergiy V. et al.

Ingår i Journal of Neuroimmunology, s. 51-58, 2017

• DOI för AMPA, NMDA and kainate glutamate receptor subunits are expressed in human peripheral blood mononuclear cells (PBMCs) where the expression of GluK4 is altered by pregnancy and GluN2D by depression in pregnant women

Liraglutide modulates GABAergic signaling in rat hippocampal CA3 pyramidal neurons predominantly by presynaptic mechanism

Babateen, Omar; Korol, Sergiy V.; Jin, Zhe; Bhandage, Amol K. et al.

Ingår i BMC Pharmacology & Toxicology, 2017

• DOI för Liraglutide modulates GABAergic signaling in rat hippocampal CA3 pyramidal neurons predominantly by presynaptic mechanism
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Characterization of the gamma-aminobutyric acid signaling system in the zebrafish (danio rerio hamilton) central nervous system by reverse transcription-quantitative polymerase chain reaction

Cocco, Arianna; Rönnberg, A. M. Carolina; Jin, Zhe; André, Goncalo Igreja et al.

Ingår i Neuroscience, s. 300-321, 2017

• DOI för Characterization of the gamma-aminobutyric acid signaling system in the zebrafish (danio rerio hamilton) central nervous system by reverse transcription-quantitative polymerase chain reaction
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Normal human CD4⁺ helper T cells express Kv1.1 voltage-gated K⁺ channels, and selective Kv1.1 block in T cells induces by itself robust TNFα production and secretion and activation of the NFκB non-canonical pathway

Fellerhoff-Losch, Barbara; Korol, Sergiy V.; Ganor, Yonatan; Gu, Songhai et al.

Ingår i Journal of neural transmission, s. 137-157, 2016

• DOI för Normal human CD4⁺ helper T cells express Kv1.1 voltage-gated K⁺ channels, and selective Kv1.1 block in T cells induces by itself robust TNFα production and secretion and activation of the NFκB non-canonical pathway

GLP-1 and Exendin-4 Transiently Enhance GABA(A) Receptor-Mediated Synaptic and Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons

Korol, Sergiy V.; Jin, Zhe; Babateen, Omar; Birnir, Bryndis

Ingår i Diabetes, s. 79-89, 2015

• DOI för GLP-1 and Exendin-4 Transiently Enhance GABA(A) Receptor-Mediated Synaptic and Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons
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The mRNA expression of GABA-A, GABA-B receptor subunits and chloride transporters in peripheral blood mononuclear cells is influenced by gender, pregnancy and depression

Bhandage, Amol; Hellgren, Charlotte; Jin, Zhe; Ólafsson, Einar et al.

Ingår i Acta Physiologica, s. 91-91, 2015

Modulation of GABAA receptor-mediated synaptic and tonic currents in the rat hippocampus by GLP-1, exendin-4 and diazepam

Korol, Sergiy V.; Jin, Zhe; Babateen, Omar; Birnir, Bryndis

Ingår i Acta Physiologica, s. 89-90, 2015

GABAergic signalling in the immune system

Barragan, A.; Weidner, J. M.; Jin, Zhe; Korpi, E. R. et al.

Ingår i Acta Physiologica, s. 819-827, 2015

• DOI för GABAergic signalling in the immune system

Etomidate, propofol and diazepam potentiate GABA-evoked GABAA currents in a cell line derived from Human glioblastoma

Babateen, Omar; Jin, Zhe; Bhandage, Amol K.; Korol, Sergiy V et al.

Ingår i European Journal of Pharmacology, s. 101-107, 2015

• DOI för Etomidate, propofol and diazepam potentiate GABA-evoked GABAA currents in a cell line derived from Human glioblastoma

Expression of GABA receptors subunits in peripheral blood mononuclear cells is gender dependent, altered in pregnancy and modified by mental health

Bhandage, Amol K.; Hellgren, Charlotte; Jin, Zhe; Olafsson, Einar B et al.

Ingår i Acta Physiologica, s. 575-585, 2015

• DOI för Expression of GABA receptors subunits in peripheral blood mononuclear cells is gender dependent, altered in pregnancy and modified by mental health

The GLP-1 Receptor Agonist Exendin-4 and Diazepam Differentially Regulate GABA_A Receptor-Mediated Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons

Korol, Sergiy V.; Jin, Zhe; Birnir, Bryndis

Ingår i PLOS ONE, 2015

• DOI för The GLP-1 Receptor Agonist Exendin-4 and Diazepam Differentially Regulate GABA_A Receptor-Mediated Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons
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Insulin modulates GABAA receptor-mediated neuronal inhibition in rat hippocampus and amygdala

Jin, Zhe; Korol, Sergiy V.; Jin, Yang; Birnir, Bryndis

Ingår i Acta Physiologica, s. 90-90, 2015

Absence of Shb impairs insulin secretion by elevated FAK activity in pancreatic islets

Alenkvist, Ida; Dyachok, Oleg; Tian, Geng; Li, Jia et al.

Ingår i Journal of Endocrinology, s. 267-275, 2014

• DOI för Absence of Shb impairs insulin secretion by elevated FAK activity in pancreatic islets
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GABA-A receptor currents in a cell line (U3047MG) derived from a human glioblastoma tumor are enhanced by etomidate, propofol and diazepam

Babateen, Omar M.; Jin, Zhe; Bhandage, Amol K.; Korol, Sergiy V. et al.

Ingår i Acta Physiologica, s. 100-100, 2014

GABA-A receptor subunit expression in human peripheral blood mononuclear cells

Bhandage, Amol K.; Hellgren, Charlotte; Jin, Zhe; Olafsson, Einar et al.

Ingår i Acta Physiologica, s. 86-86, 2014

GABA(A) receptor-mediated currents in the hippocampus are transiently enhanced by glucagon-like peptide-1 receptor (GLP-1R) agonists

Korol, Sergiy V.; Jin, Zhe; Babateen, Omar M.; Birnir, Bryndis

Ingår i Acta Physiologica, s. 83-83, 2014

Insulin modulates GABA(A) receptor-mediated inhibition in rat amygdala neurons

Jin, Zhe; Korol, Sergiy V.; Birnir, Bryndis

Ingår i Acta Physiologica, s. 83-83, 2014

Expression of specific ionotropic glutamate and GABA-A receptor subunits is decreased in central amygdala of alcoholics

Jin, Zhe; Bhandage, Amol K.; Bazov, Igor; Kononenko, Olga et al.

Ingår i Frontiers in Cellular Neuroscience, s. 288, 2014

• DOI för Expression of specific ionotropic glutamate and GABA-A receptor subunits is decreased in central amygdala of alcoholics

Selective increases of AMPA, NMDA, and kainate receptor subunit mRNAs in the hippocampus and orbitofrontal cortex but not in prefrontal cortex of human alcoholics

Jin, Zhe; Bhandage, Amol K; Bazov, Igor; Kononenko, Olga et al.

Ingår i Frontiers in Cellular Neuroscience, s. 11, 2014

• DOI för Selective increases of AMPA, NMDA, and kainate receptor subunit mRNAs in the hippocampus and orbitofrontal cortex but not in prefrontal cortex of human alcoholics

GABA-A and NMDA receptor subunit mRNA expression is altered in the caudate but not the putamen of the postmortem brains of alcoholics

Bhandage, Amol K.; Jin, Zhe; Bazov, Igor; Kononenko, Olga et al.

Ingår i Frontiers in Cellular Neuroscience, 2014

• DOI för GABA-A and NMDA receptor subunit mRNA expression is altered in the caudate but not the putamen of the postmortem brains of alcoholics

Monoacylglycerols Activate TRPV1-A Link between Phospholipase C and TRPV1

Zygmunt, Peter M.; Ermund, Anna; Movahed, Pouya; Andersson, David A. et al.

Ingår i PLOS ONE, 2013

• DOI för Monoacylglycerols Activate TRPV1-A Link between Phospholipase C and TRPV1
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In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in alpha-Cells

Jin, Yang; Korol, Sergiy V; Jin, Zhe; Barg, Sebastian et al.

Ingår i PLOS ONE, 2013

• DOI för In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in alpha-Cells
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GABA is an effective immunomodulatory molecule

Jin, Zhe; Mendu, Suresh Kumar; Birnir, Bryndis

Ingår i Amino Acids, s. 87-94, 2013

• DOI för GABA is an effective immunomodulatory molecule

gamma-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes

Taneera, J.; Jin, Zhe; Jin, Yang; Muhammed, S. J. et al.

Ingår i Diabetologia, s. 1985-1994, 2012

• DOI för gamma-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes

GABAergic Signaling Is Linked to a Hypermigratory Phenotype in Dendritic Cells Infected by Toxoplasma gondii

Fuks, Jonas M; Arrighi, Romanico B G; Weidner, Jessica M; Kumar Mendu, Suresh et al.

Ingår i PLoS pathogens, 2012

• DOI för GABAergic Signaling Is Linked to a Hypermigratory Phenotype in Dendritic Cells Infected by Toxoplasma gondii
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GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome

Smits, Anja; Jin, Zhe; Elsir, Tamador; Pedder, Hugo et al.

Ingår i PLOS ONE, 2012

• DOI för GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome
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GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium:      

Ring, Henrik; Mendu, Suresh Kumar; Shirazi-Fard, Shahrzad; Birnir, Bryndis et al.

Ingår i PLOS ONE, 2012

• DOI för GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium:      
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Different subtypes of GABA-A receptors are expressed in human, mouse and rat T lymphocytes

Mendu, Suresh Kumar; Bhandage, Amol; Jin, Zhe; Birnir, Bryndis

Ingår i PLOS ONE, 2012

• DOI för Different subtypes of GABA-A receptors are expressed in human, mouse and rat T lymphocytes
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GABA-A channel subunit expression in human glioma correlates with tumour histology and clinical outcome

Pedder, H.; Jin, Zhe; Aronica, E.; Birnir, Bryndis et al.

Ingår i European Journal of Neurology, s. 67-67, 2012

GABA is an efficient immunomodulator molecule

Jin, Zhe; Mendu, Suresh Kumar; Bhandage, Amol K.; Birnir, Bryndis

Ingår i Nerve-Driven Immunity, s. 163-173, Springer, 2012

• DOI för GABA is an efficient immunomodulator molecule

Selective Changes of GABA(A) Channel Subunit mRNAs in the Hippocampus and Orbitofrontal Cortex but not in Prefrontal Cortex of Human Alcoholics

Jin, Zhe; Bazov, Igor; Kononenko, Olga; Korpi, Esa R et al.

Ingår i Frontiers in Cellular Neuroscience, 2012

• DOI för Selective Changes of GABA(A) Channel Subunit mRNAs in the Hippocampus and Orbitofrontal Cortex but not in Prefrontal Cortex of Human Alcoholics
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Increased GABA(A) channel subunits expression in CD8(+) but not in CD4(+) T cells in BB rats developing diabetes compared to their congenic littermates

Mendu, Suresh Kumar; Åkesson, Lina; Jin, Zhe; Edlund, Anna et al.

Ingår i Molecular Immunology, s. 399-407, 2011

• DOI för Increased GABA(A) channel subunits expression in CD8(+) but not in CD4(+) T cells in BB rats developing diabetes compared to their congenic littermates

Insulin reduces neuronal excitability by turning on GABA(A) channels that generate tonic current

Jin, Zhe; Jin, Yang; Kumar-Mendu, Suresh; Degerman, Eva et al.

Ingår i PLOS ONE, 2011

• DOI för Insulin reduces neuronal excitability by turning on GABA(A) channels that generate tonic current