Sebastian Barg

Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction

Yeh, Yu-Te; Sona, Chandan; Yan, Xin; Li, Yunxiao et al.

Ingår i Nature Communications, 2023

• DOI för Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction
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SEC14-like condensate phase transitions at plasma membranes regulate root growth in Arabidopsis

Liu, Chen; Mentzelopoulou, Andriani; Papagavriil, Fotini; Ramachandran, Prashanth et al.

Ingår i PLoS biology, 2023

• DOI för SEC14-like condensate phase transitions at plasma membranes regulate root growth in Arabidopsis
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Local PI(4,5)P₂ signaling inhibits fusion pore expansion during exocytosis

Omar-Hmeadi, Muhmmad; Gucek, Alenka; Barg, Sebastian

Ingår i Cell Reports, 2023

• DOI för Local PI(4,5)P₂ signaling inhibits fusion pore expansion during exocytosis
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The β-cell primary cilium is an autonomous Ca²⁺ compartment for paracrine GABA signaling

Sanchez, Gonzalo; Incedal, Tugce Ceren; Prada, Juan; O'Callaghan, Paul et al.

Ingår i Journal of Cell Biology, 2023

• DOI för The β-cell primary cilium is an autonomous Ca²⁺ compartment for paracrine GABA signaling
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Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Balboa, Diego; Barsby, Tom; Lithovius, Väinö; Saarimäki-Vire, Jonna et al.

Ingår i Nature Biotechnology, s. 1042-1055, 2022

• DOI för Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.
• Ladda ner fulltext (pdf) av Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets

Golec, Ewelina; Ekstrom, Alexander; Noga, Maciej; Omar-Hmeadi, Muhmmad et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2022

• DOI för Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets
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In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis

Petrenko, Volodymyr; Gandasi, Nikhil; Sage, Daniel; Tengholm, Anders et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 2484-2495, 2020

• DOI för In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis
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Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.

Omar-Hmeadi, Muhmmad; Lund, Per-Eric; Gandasi, Nikhil; Tengholm, Anders et al.

Ingår i Nature Communications, 2020

• DOI för Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.
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The Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 is Essential for Proinsulin Handling

Mojtaba Ghiasi, Seyed; Dahlby, Tina; Hede Andersen, Caroline; Haataja, Leena et al.

Ingår i Diabetes, s. 747-760, 2019

• DOI för The Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 is Essential for Proinsulin Handling

Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis

Gucek, Alenka; Gandasi, Nikhil R; Omar-Hmeadi, Muhmmad; Bakke, Marit et al.

Ingår i eLIFE, 2019

• DOI för Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis
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Glucose-Dependent Granule Docking Limits Insulin Secretion and Is Decreased in Human Type 2 Diabetes

Gandasi, Nikhil R; Yin, Peng; Omar-Hmeadi, Muhmmad; Ottosson Laakso, Emilia et al.

Ingår i Cell Metabolism, s. 470-478, 2018

• DOI för Glucose-Dependent Granule Docking Limits Insulin Secretion and Is Decreased in Human Type 2 Diabetes

PtdIns(4,5)P₂ is not required for secretory granule docking

Omar-Hmeadi, Muhmmad; Gandasi, Nikhil R; Barg, Sebastian

Ingår i Traffic, s. 436-445, 2018

• DOI för PtdIns(4,5)P₂ is not required for secretory granule docking

Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells

Korol, Sergiy V; Jin, Zhe; Jin, Yang; Bhandage, Amol K. et al.

Ingår i EBioMedicine, 2018

• DOI för Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells
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Syntaxin clusters at secretory granules in a munc18-bound conformation

Yin, Peng; Gandasi, Nikhil R.; Arora, Swati; Omar-Hmeadi, Muhmmad et al.

Ingår i Molecular Biology of the Cell, s. 2700-2708, 2018

• DOI för Syntaxin clusters at secretory granules in a munc18-bound conformation
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MiR-335 overexpression impairs insulin secretion through defective priming of insulin vesicles

Salunkhe, Vishal A.; Ofori, Jones K.; Gandasi, Nikhil R; Salo, Sofia A. et al.

Ingår i Physiological Reports, 2017

• DOI för MiR-335 overexpression impairs insulin secretion through defective priming of insulin vesicles
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Ca²⁺ channel clustering with insulin-containing granules is disturbed in type 2 diabetes

Gandasi, Nikhil R.; Yin, Peng; Riz, Michela; Chibalina, Margarita V et al.

Ingår i Journal of Clinical Investigation, s. 2353-2364, 2017

• DOI för Ca²⁺ channel clustering with insulin-containing granules is disturbed in type 2 diabetes
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Plasma membrane PI(4,5)P-2 is critical for secretory granule exocytosis

Omar-Hmeadi, Muhmmad; Gandasi, Nikhil R.; Barg, Sebastian

Ingår i Molecular Biology of the Cell, s. 3727-3727, 2017

• DOI för Plasma membrane PI(4,5)P-2 is critical for secretory granule exocytosis

Recruitment of Epac2A to Insulin Granule Docking Sites Regulates Priming for Exocytosis

Alenkvist, Ida; Gandasi, Nikhil R; Barg, Sebastian; Tengholm, Anders

Ingår i Diabetes, s. 2610-2622, 2017

• DOI för Recruitment of Epac2A to Insulin Granule Docking Sites Regulates Priming for Exocytosis

How Kiss-and-Run Can Make Us Sick: SOX4 Puts a Break on the Pore

Barg, Sebastian; Gucek, Alenka

Ingår i Diabetes, s. 1791-1793, 2016

• DOI för How Kiss-and-Run Can Make Us Sick: SOX4 Puts a Break on the Pore

Plasma Membrane Phosphatidylinositol 4,5-Bisphosphate Regulates Ca2+-Influx and Insulin Secretion from Pancreatic beta Cells

Xie, Beichen; Nguyen, Phuoc My; Gucek, Alenka; Thonig, Antje et al.

Ingår i CELL CHEMICAL BIOLOGY, s. 816-826, 2016

• DOI för Plasma Membrane Phosphatidylinositol 4,5-Bisphosphate Regulates Ca2+-Influx and Insulin Secretion from Pancreatic beta Cells

Statistical Frailty Modeling for Quantitative Analysis of Exocytotic Events Recorded by Live Cell Imaging: Rapid Release of Insulin-Containing Granules Is Impaired in Human Diabetic beta-cells

Cortese, Giuliana; Gandasi, Nikhil R.; Barg, Sebastian; Pedersen, Morten Gram

Ingår i PLOS ONE, 2016

• DOI för Statistical Frailty Modeling for Quantitative Analysis of Exocytotic Events Recorded by Live Cell Imaging: Rapid Release of Insulin-Containing Granules Is Impaired in Human Diabetic beta-cells
• Ladda ner fulltext (pdf) av Statistical Frailty Modeling for Quantitative Analysis of Exocytotic Events Recorded by Live Cell Imaging: Rapid Release of Insulin-Containing Granules Is Impaired in Human Diabetic beta-cells

Quantitative Imaging of the Exocytosis Machinery Assembly

Gandasi, Nikhil R.; Barg, Sebastian

Ingår i Biophysical Journal, 2015

MiR-335 regulates exocytotic proteins and affects glucose-stimulated insulin secretion through decreased Ca2+-dependent exocytosis in beta cells

Salunkhe, V. A.; Ofori, J.; Gandasi, Nikhil R.; Salo, S. A. et al.

Ingår i Diabetologia, 2015

G-protein coupled receptor dynamics in insulin secreting cells

Kay, Emma I.; Barg, Sebastian

Ingår i Diabetologia, 2015

Survey of Red Fluorescence Proteins as Markers for Secretory Granule Exocytosis

Gandasi, Nikhil R.; Vesto, Kim; Helou, Maria; Yin, Peng et al.

Ingår i PLOS ONE, 2015

• DOI för Survey of Red Fluorescence Proteins as Markers for Secretory Granule Exocytosis
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The Complement Inhibitor CD59 Regulates Insulin Secretion by Modulating Exocytotic Events

Krus, Ulrika; King, Ben C; Nagaraj, Vini; Gandasi, Nikhil R et al.

Ingår i Cell Metabolism, s. 883-890, 2014

• DOI för The Complement Inhibitor CD59 Regulates Insulin Secretion by Modulating Exocytotic Events

CD59 is required for pancreatic beta cell insulin exocytosis

Krus, Ulrika; King, Benjamin C.; Nagaraj, Vini; Gandasi, Nikhil et al.

Ingår i Molecular Immunology, s. 279-279, 2014

Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site

Gandasi, Nikhil R; Barg, Sebastian

Ingår i Nature Communications, 2014

• DOI för Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site

Aberrant association between vascular endothelial growth factor receptor-2 and VE-cadherin in response to vascular endothelial growth factor-a in Shb-deficient lung endothelial cells

Zang, Guangxiang; Christoffersson, Gustaf; Tian, Geng; Harun-Or-Rashid, Mohammad et al.

Ingår i Cellular Signalling, s. 85-92, 2013

• DOI för Aberrant association between vascular endothelial growth factor receptor-2 and VE-cadherin in response to vascular endothelial growth factor-a in Shb-deficient lung endothelial cells
• Ladda ner fulltext (pdf) av Aberrant association between vascular endothelial growth factor receptor-2 and VE-cadherin in response to vascular endothelial growth factor-a in Shb-deficient lung endothelial cells

In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in alpha-Cells

Jin, Yang; Korol, Sergiy V; Jin, Zhe; Barg, Sebastian et al.

Ingår i PLOS ONE, 2013

• DOI för In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in alpha-Cells
• Ladda ner fulltext (pdf) av In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in alpha-Cells

PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice

Iglesias, José; Barg, Sebastian; Vallois, David; Lahiri, Shawon et al.

Ingår i Journal of Clinical Investigation, s. 4105-4117, 2012

• DOI för PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice

Multivesicular exocytosis in rat pancreatic beta cells

Hoppa, M B; Jones, E; Karanauskaite, J; Ramracheya, R et al.

Ingår i Diabetologia, s. 1001-1012, 2012

• DOI för Multivesicular exocytosis in rat pancreatic beta cells

Single secretory granules of live cells recruit syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in large copy numbers

Knowles, M. K.; Barg, Sebastian; Wan, L.; Midorikawa, M. et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 20810-20815, 2010

• DOI för Single secretory granules of live cells recruit syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in large copy numbers

Syntaxin clusters assemble reversibly at sites of secretory granules in live cells

Barg, Sebastian; Knowles, M. K.; Chen, X.; Midorikawa, M. et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 20804-20809, 2010

• DOI för Syntaxin clusters assemble reversibly at sites of secretory granules in live cells

Defective secretion of islet hormones in chromogranin-B deficient mice

Obermüller, Stefanie; Calegari, Federico; King, Angus; Lindqvist, Anders et al.

Ingår i PLOS ONE, 2010

• DOI för Defective secretion of islet hormones in chromogranin-B deficient mice

Quantitative analysis of t-SNARE and Ca2+-channel clusters near secretory granules

Barg, Sebastian; Gandasi, Nikhil

Ingår i Diabetologia, 2010

• DOI för Quantitative analysis of t-SNARE and Ca2+-channel clusters near secretory granules

cAMP Mediators of Pulsatile Insulin Secretion from Glucose-stimulated Single β-Cells

Idevall Hagren, Olof; Barg, Sebastian; Gylfe, Erik; Tengholm, Anders

Ingår i Journal of Biological Chemistry, s. 23005-23016, 2010

• DOI för cAMP Mediators of Pulsatile Insulin Secretion from Glucose-stimulated Single β-Cells

TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells

da Silva Xavier, Gabriela; Loder, Merewyn K; McDonald, Angela; Tarasov, Andrei I et al.

Ingår i Diabetes, s. 894-905, 2009

• DOI för TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells

High extracellular glucose inhibits exocytosis through disruption of syntaxin 1A-containing lipid rafts

Somanath, Sangeeta; Barg, Sebastian; Marshall, Catriona; Silwood, Christopher J et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 241-246, 2009

• DOI för High extracellular glucose inhibits exocytosis through disruption of syntaxin 1A-containing lipid rafts

Impaired glucose homeostasis in Shb-/- mice

Åkerblom, Björn; Barg, Sebastian; Calounova, Gabriela; Mokhtari, Dariush et al.

Ingår i Journal of Endocrinology, s. 271-279, 2009

• DOI för Impaired glucose homeostasis in Shb-/- mice

Compensatory endocytosis in chromaffin cells

Barg, Sebastian; Machado, Jose David

Ingår i Acta Physiologica, s. 195-201, 2008

• DOI för Compensatory endocytosis in chromaffin cells

Release of the styryl dyes from single synaptic vesicles in hippocampal neurons.

Chen, Xi; Barg, Sebastian; Almers, Wolfhard

Ingår i The Journal of neuroscience : the official journal of the Society for Neuroscience, s. 1894-1903, 2008

• DOI för Release of the styryl dyes from single synaptic vesicles in hippocampal neurons.
• Ladda ner fulltext (pdf) av Release of the styryl dyes from single synaptic vesicles in hippocampal neurons.

Granule docking and cargo release in pancreatic β-cells

Barg, Sebastian; Lindqvist, Anders; Obermüller, Stefanie

Ingår i Biochemical Society Transactions, s. 294-299, 2008

• DOI för Granule docking and cargo release in pancreatic β-cells

Selective nucleotide-release from dense-core granules in insulin-secreting cells

Obermüller, Stefanie; Lindqvist, Anders; Karanauskaite, Jovita; Galvanovskis, Juris et al.

Ingår i Journal of Cell Science, s. 4271-82, 2005

• DOI för Selective nucleotide-release from dense-core granules in insulin-secreting cells
• Ladda ner fulltext (pdf) av Selective nucleotide-release from dense-core granules in insulin-secreting cells

Membrane phosphoinositides control insulin secretion through their effects on ATP-sensitive K+ channel activity.

Lin, Chia-Wei; Yan, Feifei; Shimamura, Satoko; Barg, Sebastian et al.

Ingår i Diabetes, s. 2852-8, 2005

Large dense-core vesicle exocytosis in pancreatic beta-cells monitored by capacitance measurements.

Kanno, Takahiro; Ma, Xiasong; Barg, Sebastian; Eliasson, Lena et al.

Ingår i Methods, s. 302-11, 2004

• DOI för Large dense-core vesicle exocytosis in pancreatic beta-cells monitored by capacitance measurements.

Insulin secretion: a high-affinity Ca2+ sensor after all?

Barg, Sebastian; Rorsman, Patrik

Ingår i The Journal of General Physiology, s. 623-5, 2004

• DOI för Insulin secretion: a high-affinity Ca2+ sensor after all?

SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells.

Eliasson, Lena; Ma, Xiaosong; Renström, Erik; Barg, Sebastian et al.

Ingår i The Journal of General Physiology, s. 181-97, 2003

Mechanisms of exocytosis in insulin-secreting B-cells and glucagon-secreting A-cells.

Barg, Sebastian

Ingår i Pharmacology and Toxicology, s. 3-13, 2003

Delay between fusion pore opening and peptide release from large dense-core vesicles in neuroendocrine cells

Barg, Sebastian; Olofsson, Charlotta S; Schriever-Abeln, Jenny; Wendt, Anna et al.

Ingår i Neuron, s. 287-299, 2002

• DOI för Delay between fusion pore opening and peptide release from large dense-core vesicles in neuroendocrine cells