Joey Lau Börjesson

Strategier för att skydda transplanterade insulin-producerande beta-celler.

Jag har under de senaste åren fokuserat min forskning på cellterapi för typ 1 diabetes och beta-cellernas fysiologi. Ett stort hinder vid transplantation av insulin-producerande beta-celler är immunologiska komponenter såsom det ospecifika immunförsvaret, autoimmunitet och allogena komponenter som hämmar överlevnaden hos de transplanterade cellerna.

Forskningen i min forskargrupp är fokuserad på att skapa ett lokalt skydd mot celldöd kombinerad med induktion av lokal tolerans för transplanterade beta-celler. En möjlighet att utesluta immunhämmande läkemedel vid transplantation kan därmed bli verklig. Detta skulle möjliggöra cellterapi för majoriteten av personer med typ 1 diabetes. Det är stort fokus på protokoll för att skapa en förnybar källa av insulin-producerande från humana pluripotenta stamceller på grund av begränsad tillgång av beta-celler från konventionella organdonatorer.

I mitt forskningslab producerar vi insulin-producerande ö-liknande cellkluster från både inducerade pluripotenta stamceller och embryonala stamceller. Inducerade pluripotenta stamceller öppnar upp möjligheten att kringgå allogena reaktioner och eventuellt autoimmuna komponenter. Strategier för att skydda mot det ospecifika immunförsvaret är användning av biomaterial och/eller beklädnad av öar med skyddande celler såsom decidua celler eller mesenkymala stamceller innan transplantation. En utmaning är att identifiera strategier för klinisk användning, dvs hitta en modifikation som kan accepteras som avancerad terapiläkemedel (ATMP).

Produktion av insulin-producerande ö-liknande cellkluster framtagna från humana pluripotenta stamceller.Figur A. Ö-liknande cellkluster framtagna från humana pluripotenta stamceller i odling.Figur B. Immunfärgat ö-liknande cellkluster framtagen från humana pluripotenta stamceller.

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Publikationer

Differentiation of human pluripotent stem cells into insulin-producing islet-like clusters using nanofiltered cell culture medium

Thorngren, Julia; Vasylovska, Svitlana; Blanc, Jules; Wu, Lulu et al.

Ingår i Frontiers in Membrane Science and Technology, 2024
- DOI för Differentiation of human pluripotent stem cells into insulin-producing islet-like clusters using nanofiltered cell culture medium
- Ladda ner fulltext (pdf) av Differentiation of human pluripotent stem cells into insulin-producing islet-like clusters using nanofiltered cell culture medium
CLEC11A improves insulin secretion and promotes cell proliferation in human beta-cells

Shi, Ruifeng; Cen, Jing; Westermark, Gunilla; Zhao, Sheng et al.

Ingår i Journal of Molecular Endocrinology, 2023
- DOI för CLEC11A improves insulin secretion and promotes cell proliferation in human beta-cells
- Ladda ner fulltext (pdf) av CLEC11A improves insulin secretion and promotes cell proliferation in human beta-cells
The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets

Elksnis, Andris; Welsh, Nils; Wikström, Per; Lau, Joey et al.

Ingår i Free radical research, s. 460-469, 2023
- DOI för The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets
- Ladda ner fulltext (pdf) av The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets
Preclinical evaluation of Affibody molecule for PET imaging of human pancreatic islets derived from stem cells.

Cheung, Pierre; Thorngren, Julia; Zhang, Bo; Vasylovska, Svitlana et al.

Ingår i EJNMMI Research, s. 107, 2023
- DOI för Preclinical evaluation of Affibody molecule for PET imaging of human pancreatic islets derived from stem cells.
- Ladda ner fulltext (pdf) av Preclinical evaluation of Affibody molecule for PET imaging of human pancreatic islets derived from stem cells.
Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Balboa, Diego; Barsby, Tom; Lithovius, Väinö; Saarimäki-Vire, Jonna et al.

Ingår i Nature Biotechnology, s. 1042-1055, 2022
- DOI för Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.
- Ladda ner fulltext (pdf) av Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.
Generation of human induced pluripotent stem cell (iPSC) lines (UUMCBi001-A, UUMCBi002-A) from two healthy donors

Vasylovska, Svitlana; Schuster, Jens; Brboric, Anja; Carlsson, Per-Ola et al.

Ingår i Stem Cell Research, 2021
- DOI för Generation of human induced pluripotent stem cell (iPSC) lines (UUMCBi001-A, UUMCBi002-A) from two healthy donors
- Ladda ner fulltext (pdf) av Generation of human induced pluripotent stem cell (iPSC) lines (UUMCBi001-A, UUMCBi002-A) from two healthy donors
Interleukin-35 Prevents Development of Autoimmune Diabetes Possibly by Maintaining the Phenotype of Regulatory B Cells

Luo, Zhengkang; Lundin, Sara; Mejia Cordova, Mariela; Hassani, Imane et al.

Ingår i International Journal of Molecular Sciences, 2021
- DOI för Interleukin-35 Prevents Development of Autoimmune Diabetes Possibly by Maintaining the Phenotype of Regulatory B Cells
- Ladda ner fulltext (pdf) av Interleukin-35 Prevents Development of Autoimmune Diabetes Possibly by Maintaining the Phenotype of Regulatory B Cells
Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma

van Hooren, Luuk; Vaccaro, Alessandra; Ramachandran, Mohanraj; Vazaios, Konstantinos et al.

Ingår i Nature Communications, 2021
- DOI för Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma
- Ladda ner fulltext (pdf) av Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma
Function and Gene Expression of Islets Experimentally Transplanted to Muscle and Omentum

Espes, Daniel; Liljebäck, Hanna; Franzén, Petra; Quach, My et al.

Ingår i Cell Transplantation, s. 1-10, 2020
- DOI för Function and Gene Expression of Islets Experimentally Transplanted to Muscle and Omentum
- Ladda ner fulltext (pdf) av Function and Gene Expression of Islets Experimentally Transplanted to Muscle and Omentum
Protective effects of Clec11a in islets against lipotoxicity via modulation of proliferation and lipid metabolism in mice

Shi, Ruifeng; Hu, Juan; Li, Wei; Wang, Zhirong et al.

Ingår i Experimental Cell Research, 2019
- DOI för Protective effects of Clec11a in islets against lipotoxicity via modulation of proliferation and lipid metabolism in mice
Fewer Islets Survive from a First Transplant than a Second Transplant: Evaluation of Repeated Intraportal Islet Transplantation in Mice

Liljebäck, Hanna; Quach, My; Carlsson, Per-Ola; Lau, Joey

Ingår i Cell Transplantation, s. 1455-1460, 2019
- DOI för Fewer Islets Survive from a First Transplant than a Second Transplant: Evaluation of Repeated Intraportal Islet Transplantation in Mice
- Ladda ner fulltext (pdf) av Fewer Islets Survive from a First Transplant than a Second Transplant: Evaluation of Repeated Intraportal Islet Transplantation in Mice
Characterization of neural crest-derived stem cells isolated from human bone marrow for improvement of transplanted islet function.

Brboric, Anja; Vasylovska, Svitlana; Saarimäki-Vire, Jonna; Espes, Daniel et al.

Ingår i Upsala Journal of Medical Sciences, s. 228-237, 2019
- DOI för Characterization of neural crest-derived stem cells isolated from human bone marrow for improvement of transplanted islet function.
- Ladda ner fulltext (pdf) av Characterization of neural crest-derived stem cells isolated from human bone marrow for improvement of transplanted islet function.
Decreased beta-Cell Proliferation and Vascular Density in a Subpopulation of Low-Oxygenated Male Rat Islets

Ullsten, Sara; Lau, Joey; Carlsson, Per-Ola

Ingår i Journal of the Endocrine Society, s. 1608-1616, 2019
- DOI för Decreased beta-Cell Proliferation and Vascular Density in a Subpopulation of Low-Oxygenated Male Rat Islets
- Ladda ner fulltext (pdf) av Decreased beta-Cell Proliferation and Vascular Density in a Subpopulation of Low-Oxygenated Male Rat Islets
A Randomized Controlled Trial of Dapagliflozin Plus Once-Weekly Exenatide Versus Placebo in Individuals with Obesity and Without Diabetes: Metabolic Effects and Markers Associated with Bodyweight Loss

Pereira, Maria J; Lundkvist, Per; Kamble, Prasad G.; Lau, Joey et al.

Ingår i Diabetes Therapy, s. 1511-1532, 2018
- DOI för A Randomized Controlled Trial of Dapagliflozin Plus Once-Weekly Exenatide Versus Placebo in Individuals with Obesity and Without Diabetes: Metabolic Effects and Markers Associated with Bodyweight Loss
- Ladda ner fulltext (pdf) av A Randomized Controlled Trial of Dapagliflozin Plus Once-Weekly Exenatide Versus Placebo in Individuals with Obesity and Without Diabetes: Metabolic Effects and Markers Associated with Bodyweight Loss
Altered Glucose Uptake in Muscle, Visceral Adipose Tissue, and Brain Predict Whole-Body Insulin Resistance and may Contribute to the Development of Type 2 Diabetes: A Combined PET/MR Study

Boersma, Greta J.; Johansson, Emil; Pereira, Maria J; Heurling, Kerstin et al.

Ingår i Hormone and Metabolic Research, s. 627-639, 2018
- DOI för Altered Glucose Uptake in Muscle, Visceral Adipose Tissue, and Brain Predict Whole-Body Insulin Resistance and may Contribute to the Development of Type 2 Diabetes: A Combined PET/MR Study
Increased Expression of GLP-1R in Proliferating Islets of Men1 Mice is Detectable by [Ga-68]Ga-DO3A-VS-Cys(40)- Exendin-4/PET

Monazzam, Azita; Lau, Joey; Velikyan, Irina; Li, Su-Chen et al.

Ingår i Scientific Reports, 2018
- DOI för Increased Expression of GLP-1R in Proliferating Islets of Men1 Mice is Detectable by [Ga-68]Ga-DO3A-VS-Cys(40)- Exendin-4/PET
- Ladda ner fulltext (pdf) av Increased Expression of GLP-1R in Proliferating Islets of Men1 Mice is Detectable by [Ga-68]Ga-DO3A-VS-Cys(40)- Exendin-4/PET
Towards the clinical translation of stem cell therapy for type 1 diabetes

Espes, Daniel; Lau, Joey; Carlsson, Per-Ola

Ingår i European Journal of Endocrinology, 2017
- DOI för Towards the clinical translation of stem cell therapy for type 1 diabetes
Glucose uptake in skeletal muscle, brain and visceral adipose tissue assessed with PET/MR strongly predicts whole body glucose uptake during hyperinsulinaemia

Boersma, Greta J.; Heurling, Kerstin; Pereira, Maria J; Johansson, Emil et al.

Ingår i Diabetologia, 2017
Spinal Cord Interneurons Expressing the Gastrin-Releasing Peptide Receptor Convey Itch Through VGLUT2-Mediated Signaling

Aresh, Bejan; Freitag, Fabio B.; Perry, Sharn; Blümel, Edda et al.

Ingår i Pain, s. 945-961, 2017
- DOI för Spinal Cord Interneurons Expressing the Gastrin-Releasing Peptide Receptor Convey Itch Through VGLUT2-Mediated Signaling
- Ladda ner fulltext (pdf) av Spinal Cord Interneurons Expressing the Gastrin-Releasing Peptide Receptor Convey Itch Through VGLUT2-Mediated Signaling
Role of cannabinoid receptor 1 in human adipose tissue for lipolysis regulation and insulin resistance

Sidibeh, Cherno O.; Pereira, Maria J.; Börjesson, Joey Lau; Kamble, Prasad G. et al.

Ingår i Endocrine, s. 839-852, 2017
- DOI för Role of cannabinoid receptor 1 in human adipose tissue for lipolysis regulation and insulin resistance
- Ladda ner fulltext (pdf) av Role of cannabinoid receptor 1 in human adipose tissue for lipolysis regulation and insulin resistance
Role of cannabinoid receptor type 1 in glucocorticoid-induced insulin resistance (IR) and lipolysis regulation in human adipose tissue (AT)

Sidibeh, Cherno O.; Pereira, Maria J.; Börjesson, Joey Lau; Kamble, Prasad G. et al.

Ingår i Diabetologia, 2016
Metabolic effects of dapagliflozin QD and exenatide QW in obese adults without diabetes: a 24-week randomised placebo-controlled phase 2 study

Lundkvist, Per; Amini, Sam; Lau Börjesson, Joey; Pereira, Maria J. et al.

Ingår i Diabetologia, 2016
Skeletal muscle and liver, but not brain, account for impaired glucose utilisation in type 2 diabetes: whole-body PET/MR during hyperinsulinaemic euglycaemic clamp

Boersma, Greta J.; Johansson, Emil; Pereira, Maria J.; Skrtic, S. et al.

Ingår i Diabetologia, 2016
Small Mouse Islets Are Deficient in Glucagon-Producing Alpha Cells but Rich in Somatostatin-Secreting Delta Cells

Lau, Joey; Grapengiesser, Eva; Hellman, Bo

Ingår i Journal of Diabetes Research, 2016
- DOI för Small Mouse Islets Are Deficient in Glucagon-Producing Alpha Cells but Rich in Somatostatin-Secreting Delta Cells
- Ladda ner fulltext (pdf) av Small Mouse Islets Are Deficient in Glucagon-Producing Alpha Cells but Rich in Somatostatin-Secreting Delta Cells
Gastric bypass reduces symptoms and hormonal responses to hypoglycemia

Abrahamsson, Niclas; Lau Börjesson, Joey; Sundbom, Magnus; Wiklund, Urban et al.

Ingår i Diabetes, s. 2667-2675, 2016
- DOI för Gastric bypass reduces symptoms and hormonal responses to hypoglycemia
Endoplasmic reticulum stress enhances fibrosis through IRE1α-mediated degradation of miR-150 and XBP-1 splicing

Heindryckx, Femke; Binet, Francois; Ponticos, Markella; Rombouts, Krista et al.

Ingår i EMBO Molecular Medicine, s. 729-744, 2016
- DOI för Endoplasmic reticulum stress enhances fibrosis through IRE1α-mediated degradation of miR-150 and XBP-1 splicing
- Ladda ner fulltext (pdf) av Endoplasmic reticulum stress enhances fibrosis through IRE1α-mediated degradation of miR-150 and XBP-1 splicing
Pancreatic islet blood flow and its measurement

Jansson, Leif; Barbu, Andreea; Bodin, Birgitta; Drott, Carl Johan et al.

Ingår i Upsala Journal of Medical Sciences, s. 81-95, 2016
- DOI för Pancreatic islet blood flow and its measurement
- Ladda ner fulltext (pdf) av Pancreatic islet blood flow and its measurement
Lipocalin 2 produces insulin resistance and can be upregulated by glucocorticoids in human adipose tissue

Kamble, Prasad G.; Pereira, Maria J.; Sidibeh, Cherno O.; Amini, Sam et al.

Ingår i Molecular and Cellular Endocrinology, s. 124-132, 2016
- DOI för Lipocalin 2 produces insulin resistance and can be upregulated by glucocorticoids in human adipose tissue
Scholarly publishing threatened?

Andersson, Arne; Lau Börjesson, Joey

Ingår i Upsala Journal of Medical Sciences, s. 205-206, 2016
- DOI för Scholarly publishing threatened?
Role of cannabinoid receptor type 1 in glucocorticoid-induced lipolysis, insulin resistance and central obesity in human adipose tissue

Sidibeh, Cherno O.; Pereira, Maria João; Börjesson, Joey Lau; Kamble, Prasad G. et al.

Ingår i Diabetologia, 2015
Surface Coating of Pancreatic Islets With Neural Crest Stem Cells Improves Engraftment and Function After Intraportal Transplantation

Lau Börjesson, Joey; Vasylovska, Svitlana; Kozlova, Elena N.; Carlsson, Per-Ola

Ingår i Cell Transplantation, s. 2263-2272, 2015
- DOI för Surface Coating of Pancreatic Islets With Neural Crest Stem Cells Improves Engraftment and Function After Intraportal Transplantation
- Ladda ner fulltext (pdf) av Surface Coating of Pancreatic Islets With Neural Crest Stem Cells Improves Engraftment and Function After Intraportal Transplantation
Increased levels of irisin in people with long-standing Type1 diabetes

Espes, Daniel; Lau, Joey; Carlsson, Per-Ola

Ingår i Diabetic Medicine, s. 1172-1176, 2015
- DOI för Increased levels of irisin in people with long-standing Type1 diabetes
Operating in an era of impact factor mania

Andersson, Arne; Börjesson, Joey Lau

Ingår i Upsala Journal of Medical Sciences, s. 124-131, 2015
- DOI för Operating in an era of impact factor mania
Cotransplantation of Polymerized Hemoglobin Reduces β-Cell Hypoxia and Improves β-Cell Function in Intramuscular Islet Grafts

Espes, Daniel; Lau, Joey; Quach, My; Banerjee, Uddyalok et al.

Ingår i Transplantation, s. 2077-2082, 2015
- DOI för Cotransplantation of Polymerized Hemoglobin Reduces β-Cell Hypoxia and Improves β-Cell Function in Intramuscular Islet Grafts
Vascular heterogeneity between native rat pancreatic islets is responsible for differences in survival and revascularisation post transplantation

Ullsten, Sara; Lau, Joey; Carlsson, Per-Ola

Ingår i Diabetologia, s. 132-139, 2015
- DOI för Vascular heterogeneity between native rat pancreatic islets is responsible for differences in survival and revascularisation post transplantation
Neural crest stem cells from hair follicles and boundary cap have different effects on pancreatic islets in vitro

Kosykh, Anastasiia; Ngamjariyawat, Anongnad; Vasylovska, Svitlana; König, Niclas et al.

Ingår i International Journal of Neuroscience, s. 547-554, 2015
- DOI för Neural crest stem cells from hair follicles and boundary cap have different effects on pancreatic islets in vitro
Signatures of post-zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer

Forsberg, Lars A.; Rasi, Chiara; Pekar, Gyula; Davies, Hanna et al.

Ingår i Genome Research, s. 1521-1535, 2015
- DOI för Signatures of post-zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer
- Ladda ner fulltext (pdf) av Signatures of post-zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer
Laser Microdissection of Pancreatic Islets Allows for Quantitative Real-Time PCR Detection of Islet-Specific Gene Expression in Healthy and Diabetic Cats

Öhlund, Malin; Franzén, Petra; Andersson, Göran; Ström Holst, Bodil et al.

Ingår i Journal of Gastroenterology, Pancreatology & Liver Disorders, s. 1-9, 2014
- Ladda ner fulltext (pdf) av Laser Microdissection of Pancreatic Islets Allows for Quantitative Real-Time PCR Detection of Islet-Specific Gene Expression in Healthy and Diabetic Cats
Improving Pancreatic Islet Engraftment after Islet Transplantation through Administration of Gamma-Secretase Inhibitor DAPT

Hjelmqvist, Daisy; Hellström, Mats; Lau, Joey

Ingår i Journal of endocrinology and diabetes mellitus, s. 65-69, 2014
- DOI för Improving Pancreatic Islet Engraftment after Islet Transplantation through Administration of Gamma-Secretase Inhibitor DAPT
- Ladda ner fulltext (pdf) av Improving Pancreatic Islet Engraftment after Islet Transplantation through Administration of Gamma-Secretase Inhibitor DAPT
Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes

Espes, Daniel; Lau, Joey; Carlsson, Per-Ola

Ingår i Diabetologia, s. 50-53, 2014
- DOI för Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes
Surface-Coating of Pancreatic Islets with Neural Crest Stem Cells Improves Islet Engraftment and Function After Intraportal Transplantation

Lau, Joey; Vasylovska, Svitlana; Kozlova, Elena; Carlsson, Per-Ola

Ingår i Transplantation, 2013
Draft Copy Incorporation of Gelatin Scaffolds with Islets for Transplantation Improves Islet Engraftment and Post Transplant Function

Sandberg, Monica; Lau, Joey; Carlsson, Per-Ola

Ingår i Transplantation, 2013
Vascular Heterogeneity Between Native Pancreatic Islets Determines Their Fate of Survival and Revascularization Posttransplantation

Ullsten, Sara; Lau, Joey; Welsh, Nils; Carlsson, Per-Ola

Ingår i Transplantation, 2013
Restored Vascular Density and Blood Fow in Mouse and Human Islets Experimentally Transplanted to The Greater Omentum

Espes, Daniel; Lau, Joey; Christoffersson, Gustaf; Quach, My et al.

Ingår i Transplantation, 2013
Hypoxia in Islets After Intramuscular Transplantation can be Overcome by Co-Implantation of Polymerized Hemoglobin

Espes, Daniel; Lau, Joey; Quach, My; Palmer, Andre F. et al.

Ingår i Transplantation, 2013
Blood flow in endogenous and transplanted pancreatic islets in anesthetized rats: Effects of lactate and pyruvate

Barbu, Andreea; Johansson, Åsa; Bodin, Bbirgitta; Källskog, Örjan et al.

Ingår i Pancreas, s. 1263-1271, 2012
- DOI för Blood flow in endogenous and transplanted pancreatic islets in anesthetized rats: Effects of lactate and pyruvate
Markedly Decreased Blood Perfusion of Pancreatic Islets Transplanted Intraportally Into the Liver: Disruption of Islet Integrity Necessary for Islet Revascularization

Henriksnäs, Johanna; Lau, Joey; Zang, Guangxiang; Berggren, Per-Olof et al.

Ingår i Diabetes, s. 665-673, 2012
- DOI för Markedly Decreased Blood Perfusion of Pancreatic Islets Transplanted Intraportally Into the Liver: Disruption of Islet Integrity Necessary for Islet Revascularization
Superior beta cell proliferation, function and gene expression in a subpopulation of rat islets identified by high blood perfusion

Lau, Joey; Svensson, J.; Grapensparr, Liza; Johansson, Å et al.

Ingår i Diabetologia, s. 1390-1399, 2012
- DOI för Superior beta cell proliferation, function and gene expression in a subpopulation of rat islets identified by high blood perfusion
Striated Muscle as Implantation Site for Transplanted Pancreatic Islets

Espes, Daniel; Eriksson, Olof; Lau, Joey; Carlsson, Per-Ola

Ingår i Journal of Transplantation, s. 352043, 2011
- DOI för Striated Muscle as Implantation Site for Transplanted Pancreatic Islets
High Vascular Density and Oxygenation of Pancreatic Islets Transplanted in Clusters Into Striated Muscle

Svensson, Johanna; Lau, Joey; Sandberg, Monica; Carlsson, Per-Ola

Ingår i Cell Transplantation, s. 783-788, 2011
- DOI för High Vascular Density and Oxygenation of Pancreatic Islets Transplanted in Clusters Into Striated Muscle