Klinisk epidemiologi
![Johan Sundström i ett datalagringrum.](/images/200.300bef8f18f0f87bbe91f213/1714371198243/_MG_9052_1932x828.jpg)
Vi skapar värde för patienter och populationer med big data.
Beskrivning av vår forskning
![En anatomisk modell av en människa där man ser hud, senor, blodkärl, ögon och hjärna.](/images/200.300bef8f18f0f87bbe91f2b2/1714371559086/_MG_8986.jpg)
Foto: Mikael Wallerstedt.
Vår forskargrupp leder ett nationellt strategiskt forskningsprogram inom epidemiologi. Vi använder många av Sveriges kohorter i vår forskning, har samlat in några av dem själva, och vi leder ett nationellt initiativ för att öka värdet av alla svenska kohorter. Vi leder också randomiserade kliniska prövningar, huvudsakligen inom kardiometabola sjukdomar och akutsjukvård, och gör systematiska litteraturöversikter och meta-analyser.
Vår metodutveckling är inriktad på att använda stora databaser, big data, för att förbättra sjukvårdens riskbedömning, behandlingsbeslut och utvärdering av behandlingseffekter, risker och kostnader. Förutom traditionella datakällor, som kliniska prövningar och kohorter med eller utan omics-data, så använder vi nya källor som elektroniska journaler och patientgenererade data. Vi använder kausal inferens-metoder som Mendelsk randomisering, kausala diagram och propensity score-baserade metoder. Vi använder också maskininlärningsmetoder och utvecklar nya digitala metoder för klinisk forskning.
Publikationer
Ingår i Circulation Heart Failure, 2024
Ingår i EBioMedicine, 2024
- DOI för Accelerometer-based physical activity is associated with the gut microbiota in 8416 individuals in SCAPIS
- Ladda ner fulltext (pdf) av Accelerometer-based physical activity is associated with the gut microbiota in 8416 individuals in SCAPIS
Dietary patterns, untargeted metabolite profiles and their association with colorectal cancer risk
Ingår i Scientific Reports, 2024
- DOI för Dietary patterns, untargeted metabolite profiles and their association with colorectal cancer risk
- Ladda ner fulltext (pdf) av Dietary patterns, untargeted metabolite profiles and their association with colorectal cancer risk
Usefulness of Heart Failure Categories Based on Left Ventricular Ejection Fraction
Ingår i Journal of the American Heart Association, 2024
- DOI för Usefulness of Heart Failure Categories Based on Left Ventricular Ejection Fraction
- Ladda ner fulltext (pdf) av Usefulness of Heart Failure Categories Based on Left Ventricular Ejection Fraction
Ingår i BMC Health Services Research, 2024
- DOI för Factors predictive of hospital admission for children via emergency departments in Australia and Sweden: an observational cross-sectional study
- Ladda ner fulltext (pdf) av Factors predictive of hospital admission for children via emergency departments in Australia and Sweden: an observational cross-sectional study
Ingår i Respiratory Research, 2024
- DOI för Exertional breathlessness related to medical conditions in middle-aged people: the population-based SCAPIS study of more than 25,000 men and women
- Ladda ner fulltext (pdf) av Exertional breathlessness related to medical conditions in middle-aged people: the population-based SCAPIS study of more than 25,000 men and women
Ingår i Eur J Epidemiol, 2024
Analysis of plasma metabolomes from 11 309 subjects in five population-based cohorts.
Ingår i Scientific Reports, s. 8933, 2024
Markers of imminent myocardial infarction
Ingår i Nature Cardiovascular Research, 2024
- DOI för Markers of imminent myocardial infarction
- Ladda ner fulltext (pdf) av Markers of imminent myocardial infarction
More Evidence That HF With Normal EF Is Distinct From HF Below Normal EF
Ingår i Journal of the American College of Cardiology, s. 1740-1742, 2024
Ingår i Mayo Clinic proceedings, s. 69-80, 2024
- DOI för Life's Essential 8 and Life's Simple 7 in Relation to Coronary Atherosclerosis: Results From the Population-Based SCAPIS Project
- Ladda ner fulltext (pdf) av Life's Essential 8 and Life's Simple 7 in Relation to Coronary Atherosclerosis: Results From the Population-Based SCAPIS Project
Ingår i Stroke, s. 50-58, 2024
Ingår i BMC Oral Health, 2024
- DOI för Does smoking cessation affect postoperative healing following oral surgery among smokers?: a systematic review
- Ladda ner fulltext (pdf) av Does smoking cessation affect postoperative healing following oral surgery among smokers?: a systematic review
An association between heart rate variability and incident heart failure in an elderly cohort
Ingår i Clinical Cardiology, 2024
- DOI för An association between heart rate variability and incident heart failure in an elderly cohort
- Ladda ner fulltext (pdf) av An association between heart rate variability and incident heart failure in an elderly cohort
Ingår i The Lancet, s. 1027-1050, 2024
- DOI för Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
- Ladda ner fulltext (pdf) av Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
Ingår i Environment International, 2024
- DOI för Socio-demographic inequalities influence differences in the chemical exposome among Swedish adolescents
- Ladda ner fulltext (pdf) av Socio-demographic inequalities influence differences in the chemical exposome among Swedish adolescents
Ingår i Journal of Mass Spectrometry, 2024
- DOI för Assessing the performance of a targeted absolute quantification isotope dilution liquid chromatograhy tandem mass spectrometry assay versus a commercial nontargeted relative quantification assay for detection of three major perfluoroalkyls in human blood
- Ladda ner fulltext (pdf) av Assessing the performance of a targeted absolute quantification isotope dilution liquid chromatograhy tandem mass spectrometry assay versus a commercial nontargeted relative quantification assay for detection of three major perfluoroalkyls in human blood
Are there lost opportunities in chronic kidney disease?: A region-wide cohort study
Ingår i BMJ Open, 2024
- DOI för Are there lost opportunities in chronic kidney disease?: A region-wide cohort study
- Ladda ner fulltext (pdf) av Are there lost opportunities in chronic kidney disease?: A region-wide cohort study
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
Ingår i Nature, s. 347-357, 2024
- DOI för Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
- Ladda ner fulltext (pdf) av Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
Ingår i Journal of Clinical Medicine, 2024
- DOI för The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Increased Glomerular Production or Permeability in Diabetes Mellitus?
- Ladda ner fulltext (pdf) av The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Increased Glomerular Production or Permeability in Diabetes Mellitus?
Ingår i Scientific Reports, 2024
- DOI för A combined observational and Mendelian randomization investigation reveals NMR-measured analytes to be risk factors of major cardiovascular diseases
- Ladda ner fulltext (pdf) av A combined observational and Mendelian randomization investigation reveals NMR-measured analytes to be risk factors of major cardiovascular diseases
Ingår i Chest, s. 503-516, 2023
- DOI för OSA Is Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study
- Ladda ner fulltext (pdf) av OSA Is Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study
Ingår i European Journal of Preventive Cardiology, s. 1007-1014, 2023
Ingår i Atherosclerosis, s. 46-54, 2023
- DOI för Body weight at age 20 and in midlife is more important than weight gain for coronary atherosclerosis: Results from SCAPIS
- Ladda ner fulltext (pdf) av Body weight at age 20 and in midlife is more important than weight gain for coronary atherosclerosis: Results from SCAPIS
Loci for insulin processing and secretion provide insight into type 2 diabetes risk.
Ingår i American Journal of Human Genetics, s. 284-299, 2023
Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
Ingår i Clinical Proteomics, 2023
- DOI för Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
- Ladda ner fulltext (pdf) av Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
A machine learning based approach to identify carotid subclinical atherosclerosis endotypes
Ingår i Cardiovascular Research, s. 2594-2606, 2023
Ingår i Psychiatry Research, 2023
- DOI för The association between exposure to clozapine, olanzapine, and quetiapine and the outcomes perimyocarditis and heart failure: A population-based cohort study
- Ladda ner fulltext (pdf) av The association between exposure to clozapine, olanzapine, and quetiapine and the outcomes perimyocarditis and heart failure: A population-based cohort study
Ingår i Journal of Exposure Science and Environmental Epidemiology, s. 748-756, 2023
- DOI för Associations between per- and polyfluoroalkyl substances (PFAS) and diabetes in two population-based cohort studies from Sweden
- Ladda ner fulltext (pdf) av Associations between per- and polyfluoroalkyl substances (PFAS) and diabetes in two population-based cohort studies from Sweden
Ingår i Environment International, 2023
- DOI för Plasma levels of per- and polyfluoroalkyl substances (PFAS) and cardiovascular disease - Results from two independent population-based cohorts and a meta-analysis
- Ladda ner fulltext (pdf) av Plasma levels of per- and polyfluoroalkyl substances (PFAS) and cardiovascular disease - Results from two independent population-based cohorts and a meta-analysis
Ingår i BMJ Open, 2023
- DOI för Accelerometer derived physical activity and subclinical coronary and carotid atherosclerosis: cross-sectional analyses in 22 703 middle-aged men and women in the SCAPIS study
- Ladda ner fulltext (pdf) av Accelerometer derived physical activity and subclinical coronary and carotid atherosclerosis: cross-sectional analyses in 22 703 middle-aged men and women in the SCAPIS study
Ingår i Journal of Advanced Nursing, s. 3115-3126, 2023
- DOI för Fundamental nursing actions for frail older people in the emergency department: A national cross-sectional survey and a qualitative analysis of practice guidelines
- Ladda ner fulltext (pdf) av Fundamental nursing actions for frail older people in the emergency department: A national cross-sectional survey and a qualitative analysis of practice guidelines
Ingår i BMJ Open, 2023
- DOI för Multicentre, national, investigator-initiated, randomised, parallel-group, register-based superiority trial to compare extended ECG monitoring versus standard ECG monitoring in elderly patients with ischaemic stroke or transient ischaemic attack and the effect on stroke, death and intracerebral bleeding: the AF SPICE protocol
- Ladda ner fulltext (pdf) av Multicentre, national, investigator-initiated, randomised, parallel-group, register-based superiority trial to compare extended ECG monitoring versus standard ECG monitoring in elderly patients with ischaemic stroke or transient ischaemic attack and the effect on stroke, death and intracerebral bleeding: the AF SPICE protocol
Ingår i Journal of the American College of Cardiology, s. 1343-1359, 2023
Ingår i Clinical Gastroenterology and Hepatology, 2023
- DOI för Patients With Microscopic Colitis Are at Higher Risk of Major Adverse Cardiovascular Events: A Matched Cohort Study
- Ladda ner fulltext (pdf) av Patients With Microscopic Colitis Are at Higher Risk of Major Adverse Cardiovascular Events: A Matched Cohort Study
Ingår i Clinical Nutrition, s. 1922-1931, 2023
- DOI för Diet composition, nutrient substitutions and circulating fatty acids in relation to ectopic and visceral fat depots
- Ladda ner fulltext (pdf) av Diet composition, nutrient substitutions and circulating fatty acids in relation to ectopic and visceral fat depots
Ingår i European Journal of Nutrition, s. 145-153, 2023
- DOI för Substitution analyses of foods with varying fat quality and the associations with all-cause mortality and impact of the FADS-1 genotype in elderly men
- Ladda ner fulltext (pdf) av Substitution analyses of foods with varying fat quality and the associations with all-cause mortality and impact of the FADS-1 genotype in elderly men
Cardiovascular Outcomes in Patients With Biopsy-proven Alcohol-related Liver Disease
Ingår i Clinical Gastroenterology and Hepatology, s. 1841-1853000000000000, 2023
- DOI för Cardiovascular Outcomes in Patients With Biopsy-proven Alcohol-related Liver Disease
- Ladda ner fulltext (pdf) av Cardiovascular Outcomes in Patients With Biopsy-proven Alcohol-related Liver Disease
Ingår i JACC Cardiovascular Imaging, s. 1193-1204, 2023
Associations of perfluoroalkyl substances (PFAS) with lipid and lipoprotein profiles
Ingår i Journal of Exposure Science and Environmental Epidemiology, s. 757-765, 2023
- DOI för Associations of perfluoroalkyl substances (PFAS) with lipid and lipoprotein profiles
- Ladda ner fulltext (pdf) av Associations of perfluoroalkyl substances (PFAS) with lipid and lipoprotein profiles
Life's Essential 8 and carotid artery plaques: the Swedish cardiopulmonary bioimage study
Ingår i Frontiers in Cardiovascular Medicine, 2023
- DOI för Life's Essential 8 and carotid artery plaques: the Swedish cardiopulmonary bioimage study
- Ladda ner fulltext (pdf) av Life's Essential 8 and carotid artery plaques: the Swedish cardiopulmonary bioimage study
Ingår i Scandinavian Journal of Public Health, s. 527-530, 2023
- DOI för Low prevalence of ideal cardiovascular health in the general Swedish population: Results from the Swedish CArdioPulmonary bioImage Study (SCAPIS)
- Ladda ner fulltext (pdf) av Low prevalence of ideal cardiovascular health in the general Swedish population: Results from the Swedish CArdioPulmonary bioImage Study (SCAPIS)
Ingår i BMC Geriatrics, 2023
- DOI för Prevalence of frailty and associated factors in older adults seeking care at Swedish emergency departments
- Ladda ner fulltext (pdf) av Prevalence of frailty and associated factors in older adults seeking care at Swedish emergency departments
Ingår i The Lancet Diabetes and Endocrinology, s. 731-742, 2023
- DOI för Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation
- Ladda ner fulltext (pdf) av Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation
Ingår i Frontiers In Public Health, 2023
- DOI för Sodium content in processed food items in Sweden compared to other countries: a cross-sectional multinational study
- Ladda ner fulltext (pdf) av Sodium content in processed food items in Sweden compared to other countries: a cross-sectional multinational study
Ingår i The Lancet Global Health, 2023
- DOI för Global burden of peripheral artery disease and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- Ladda ner fulltext (pdf) av Global burden of peripheral artery disease and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
Ingår i Cogent Social Sciences, 2023
- DOI för Medical students experience mistreatment, with a focus on gender discrimination. Cross-sectional study at one Swedish medical school
- Ladda ner fulltext (pdf) av Medical students experience mistreatment, with a focus on gender discrimination. Cross-sectional study at one Swedish medical school
‘No more heroes’: The ILC Oxford Statement on fundamental care in times of crises
Ingår i Journal of Advanced Nursing, s. 922-932, 2023
- DOI för ‘No more heroes’: The ILC Oxford Statement on fundamental care in times of crises
- Ladda ner fulltext (pdf) av ‘No more heroes’: The ILC Oxford Statement on fundamental care in times of crises
Single-cell transcriptome dataset of human and mouse in vitro adipogenesis models
Ingår i Scientific Data, 2023
- DOI för Single-cell transcriptome dataset of human and mouse in vitro adipogenesis models
- Ladda ner fulltext (pdf) av Single-cell transcriptome dataset of human and mouse in vitro adipogenesis models
The metabolic profile of waist to hip ratio-A multi-cohort study
Ingår i PLOS ONE, 2023
- DOI för The metabolic profile of waist to hip ratio-A multi-cohort study
- Ladda ner fulltext (pdf) av The metabolic profile of waist to hip ratio-A multi-cohort study