Kardiologi
![Två läkare i skyddsutrustning opererar en patient.](/images/200.3198dce818f28e9f7c85ecc/1714403735340/PCI-labbet_K3A7212_1932x828.jpg)
Hjärt-kärlsjukdom är den vanligaste dödsorsaken globalt och medför stort lidande och höga kostnader för individ och samhälle. Under mer än 25 år har kardiologsektionens forskningsgrupp varit ledande inom forskning och utveckling kring bland annat kranskärlsjukdom och antitrombotisk behandling och inom biomarkörforskning.
Beskrivning av vår forskning
Vi har studerat metoder att optimera vård och medicinering, utan att samtidigt öka risken för komplikationer. Under senare år har gruppen även drivit framgångsrika studier och projekt inom klaffsjukdomar och studier av strokeförebyggande behandling vid förmaksflimmer. Forskningen omfattar hela spektret från cellbiologisk forskning till registerbaserade randomiserade kliniska studier (R-RCT) och inkluderar ofta randomiserade kliniska prövningar med patienter och kontrollpersoner från många olika länder.
Vårt mål är att förbättra behandling och omhändertagande av den enskilda patienten och vi bedriver forsknngsprojekt inom följande områden:
- Sjukdomsförekomst och sjukdomsmekanismer genom epidemiologiska register- och kohortstudierstudier, patofysiologiska studier samt diagnos, riskbedömning och individualiserad behandling.
- Biomarkörstudier genom bilddiagnostikstudier (s.k. imaging) samt utvärdering av nya (och gamla) terapier.
- Internationella läkemedelsprövningar genom oberoende register randomiserade kliniska prövningar, observationella register- och kohortstudier samt implementation av nya terapier.
- Observationella registerstudier.
Publikationer
Symptoms during pregnancy in primiparous women with congenital heart disease
Ingår i Scandinavian Cardiovascular Journal, 2024
- DOI för Symptoms during pregnancy in primiparous women with congenital heart disease
- Ladda ner fulltext (pdf) av Symptoms during pregnancy in primiparous women with congenital heart disease
Ingår i Structural Heart, 2024
- DOI för Characteristics and Outcomes of Patients Receiving a Second Rescue Valve During Transcatheter Aortic Valve Implantation
- Ladda ner fulltext (pdf) av Characteristics and Outcomes of Patients Receiving a Second Rescue Valve During Transcatheter Aortic Valve Implantation
Ingår i Acta Obstetricia et Gynecologica Scandinavica, 2024
Temporal biomarker concentration patterns during the early course of acute coronary syndrome
Ingår i Clinical Chemistry and Laboratory Medicine, s. 1167-1176, 2024
- DOI för Temporal biomarker concentration patterns during the early course of acute coronary syndrome
- Ladda ner fulltext (pdf) av Temporal biomarker concentration patterns during the early course of acute coronary syndrome
Ingår i Eur J Epidemiol, 2024
Ingår i Open heart, 2024
- DOI för Major bleeding in patients with atrial fibrillation treated with apixaban versus warfarin in combination with amiodarone: nationwide cohort study
- Ladda ner fulltext (pdf) av Major bleeding in patients with atrial fibrillation treated with apixaban versus warfarin in combination with amiodarone: nationwide cohort study
Analysis of plasma metabolomes from 11 309 subjects in five population-based cohorts.
Ingår i Scientific Reports, s. 8933, 2024
Ingår i Journal of the American Heart Association, 2024
- DOI för Repeated Measurement of the Novel Atrial Biomarker BMP10 (Bone Morphogenetic Protein 10) Refines Risk Stratification in Anticoagulated Patients With Atrial Fibrillation: Insights From the ARISTOTLE Trial
- Ladda ner fulltext (pdf) av Repeated Measurement of the Novel Atrial Biomarker BMP10 (Bone Morphogenetic Protein 10) Refines Risk Stratification in Anticoagulated Patients With Atrial Fibrillation: Insights From the ARISTOTLE Trial
Ingår i British Journal of Sports Medicine, 2024
- DOI för Physical fitness in male adolescents and atherosclerosis in middle age: a population-based cohort study
- Ladda ner fulltext (pdf) av Physical fitness in male adolescents and atherosclerosis in middle age: a population-based cohort study
Breastfeeding in primiparous women with congenital heart disease: a register study
Ingår i International Breastfeeding Journal, 2024
- DOI för Breastfeeding in primiparous women with congenital heart disease: a register study
- Ladda ner fulltext (pdf) av Breastfeeding in primiparous women with congenital heart disease: a register study
Ingår i Scandinavian Cardiovascular Journal, 2024
- DOI för Self-rated health in primiparous women with congenital heart disease before, during and after pregnancy: A register study
- Ladda ner fulltext (pdf) av Self-rated health in primiparous women with congenital heart disease before, during and after pregnancy: A register study
Dapagliflozin in patients with myocardial infarction without diabetes or prior heart failure
Ingår i European Heart Journal - Cardiovascular Pharmacotherapy, s. 91-92, 2024
- DOI för Dapagliflozin in patients with myocardial infarction without diabetes or prior heart failure
Time to childbirth and assisted reproductive treatment in women with congenital heart disease
Ingår i Open heart, 2024
- DOI för Time to childbirth and assisted reproductive treatment in women with congenital heart disease
- Ladda ner fulltext (pdf) av Time to childbirth and assisted reproductive treatment in women with congenital heart disease
Ingår i Diabetologia, 2024
Ingår i European Journal of Cardiovascular Nursing, 2024
Ingår i Europace, 2024
- DOI för Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference
- Ladda ner fulltext (pdf) av Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference
Ingår i Scandinavian Journal of Gastroenterology, s. 425-432, 2024
- DOI för Tofacitinib real-world experience in ulcerative colitis in Finland (FinTofUC): a retrospective non-interventional multicenter patient chart data study
- Ladda ner fulltext (pdf) av Tofacitinib real-world experience in ulcerative colitis in Finland (FinTofUC): a retrospective non-interventional multicenter patient chart data study
An association between heart rate variability and incident heart failure in an elderly cohort
Ingår i Clinical Cardiology, 2024
- DOI för An association between heart rate variability and incident heart failure in an elderly cohort
- Ladda ner fulltext (pdf) av An association between heart rate variability and incident heart failure in an elderly cohort
Ingår i Circulation, s. 932-943, 2024
Optimizing warfarin dosing for patients with atrial fibrillation using machine learning
Ingår i Scientific Reports, 2024
- DOI för Optimizing warfarin dosing for patients with atrial fibrillation using machine learning
- Ladda ner fulltext (pdf) av Optimizing warfarin dosing for patients with atrial fibrillation using machine learning
Heart failure registries - Future directions
Ingår i Journal of Cardiology, s. 84-90, 2024
Ingår i Journal of the American Heart Association, 2024
- DOI för Sex Differences in Revascularization, Treatment Goals, and Outcomes of Patients With Chronic Coronary Disease: Insights From the ISCHEMIA Trial
- Ladda ner fulltext (pdf) av Sex Differences in Revascularization, Treatment Goals, and Outcomes of Patients With Chronic Coronary Disease: Insights From the ISCHEMIA Trial
Ingår i ESC Heart Failure, s. 44-53, 2024
- DOI för Outcome prediction by myocardial external efficiency from 11C-acetate positron emission tomography in cardiac amyloidosis
- Ladda ner fulltext (pdf) av Outcome prediction by myocardial external efficiency from 11C-acetate positron emission tomography in cardiac amyloidosis
Ingår i Clinical Kidney Journal, 2024
- DOI för Associations between inflammatory and angiogenic proteomic biomarkers, and cardiovascular events and mortality in relation to kidney function
- Ladda ner fulltext (pdf) av Associations between inflammatory and angiogenic proteomic biomarkers, and cardiovascular events and mortality in relation to kidney function
Thromboembolic and bleeding events after valvular intervention in patients with atrial fibrillation
Ingår i Open heart, 2024
- DOI för Thromboembolic and bleeding events after valvular intervention in patients with atrial fibrillation
- Ladda ner fulltext (pdf) av Thromboembolic and bleeding events after valvular intervention in patients with atrial fibrillation
Ingår i Clinical Chemistry and Laboratory Medicine, s. 729-739, 2024
- DOI för Prognostic significance of chronic myocardial injury diagnosed by three different cardiac troponin assays in patients admitted with suspected acute coronary syndrome
- Ladda ner fulltext (pdf) av Prognostic significance of chronic myocardial injury diagnosed by three different cardiac troponin assays in patients admitted with suspected acute coronary syndrome
Ingår i Upsala Journal of Medical Sciences, 2024
- DOI för A retrospective nationwide analysis of evolocumab use in Sweden and its effect on low-density lipoprotein cholesterol levels
- Ladda ner fulltext (pdf) av A retrospective nationwide analysis of evolocumab use in Sweden and its effect on low-density lipoprotein cholesterol levels
Ingår i JAMA Network Open, 2024
- DOI för Application of the Universal Definition of Myocardial Infarction in Clinical Practice in Scotland and Sweden
- Ladda ner fulltext (pdf) av Application of the Universal Definition of Myocardial Infarction in Clinical Practice in Scotland and Sweden
Ingår i European Journal of Clinical Investigation, 2024
Comorbidities in childhood atopic dermatitis: A population-based study
Ingår i Journal of the European Academy of Dermatology and Venereology, s. 354-364, 2024
- DOI för Comorbidities in childhood atopic dermatitis: A population-based study
- Ladda ner fulltext (pdf) av Comorbidities in childhood atopic dermatitis: A population-based study
Ingår i Circulation, s. 290-292, 2024
Ingår i IJC Heart & Vasculature, 2024
- DOI för Provision of professional interpreters and Heart School attendance for foreign-born compared with native-born myocardial infarction patients in Sweden
- Ladda ner fulltext (pdf) av Provision of professional interpreters and Heart School attendance for foreign-born compared with native-born myocardial infarction patients in Sweden
Ingår i Implementation Science, 2024
- DOI för The effect of audit and feedback and implementation support on guideline adherence and patient outcomes in cardiac rehabilitation: a study protocol for an open-label cluster-randomized effectiveness-implementation hybrid trial
- Ladda ner fulltext (pdf) av The effect of audit and feedback and implementation support on guideline adherence and patient outcomes in cardiac rehabilitation: a study protocol for an open-label cluster-randomized effectiveness-implementation hybrid trial
Ingår i European Heart Journal - Quality of Care and Clinical Outcomes, s. 529-536, 2023
Providers, peers and patients. How do physicians?: practice environments affect patient outcomes?
Ingår i Journal of Health Economics, 2023
The role of imaging in the selection of patients for HFpEF therapy
Ingår i European Heart Journal Cardiovascular Imaging, s. 1343-1351, 2023
- DOI för The role of imaging in the selection of patients for HFpEF therapy
- Ladda ner fulltext (pdf) av The role of imaging in the selection of patients for HFpEF therapy
Ingår i European Heart Journal - Quality of Care and Clinical Outcomes, s. 609-620, 2023
- DOI för Data standards for atrial fibrillation/flutter and catheter ablation: The European Unified Registries for Heart Care Evaluation and Randomized Trials (EuroHeart)
- Ladda ner fulltext (pdf) av Data standards for atrial fibrillation/flutter and catheter ablation: The European Unified Registries for Heart Care Evaluation and Randomized Trials (EuroHeart)
Plasma angiopoietin-2 and its association with heart failure in patients with atrial fibrillation
Ingår i Europace, 2023
- DOI för Plasma angiopoietin-2 and its association with heart failure in patients with atrial fibrillation
- Ladda ner fulltext (pdf) av Plasma angiopoietin-2 and its association with heart failure in patients with atrial fibrillation
Outcomes of patients with atrial fibrillation and ischemic stroke while on oral anticoagulation
Ingår i European Heart Journal, s. 1807-1814, 2023
Ingår i Atherosclerosis, s. 46-54, 2023
- DOI för Body weight at age 20 and in midlife is more important than weight gain for coronary atherosclerosis: Results from SCAPIS
- Ladda ner fulltext (pdf) av Body weight at age 20 and in midlife is more important than weight gain for coronary atherosclerosis: Results from SCAPIS
Ingår i Circulation, s. 1207-1219, 2023
Loci for insulin processing and secretion provide insight into type 2 diabetes risk.
Ingår i American Journal of Human Genetics, s. 284-299, 2023
Ingår i Scientific Reports, 2023
- DOI för Association between high-sensitivity C-reactive protein and coronary atherosclerosis in a general middle-aged population
- Ladda ner fulltext (pdf) av Association between high-sensitivity C-reactive protein and coronary atherosclerosis in a general middle-aged population
A machine learning based approach to identify carotid subclinical atherosclerosis endotypes
Ingår i Cardiovascular Research, s. 2594-2606, 2023
Ingår i Journal of Cardiovascular Translational Research, s. 244-254, 2023
- DOI för Screening for Biomarkers Associated with Left Ventricular Function During Follow-up After Acute Coronary Syndrome
- Ladda ner fulltext (pdf) av Screening for Biomarkers Associated with Left Ventricular Function During Follow-up After Acute Coronary Syndrome
Ingår i European Heart Journal - Cardiovascular Pharmacotherapy, s. 399-400, 2023
Ingår i Cardiovascular Research, s. 1596-1605, 2023
Ingår i HEART RHYTHM O2, s. 200-206, 2023
- DOI för Prognostic value of early sustained ventricular arrhythmias in ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention: A substudy of VALIDATE-SWEDEHEART trial
- Ladda ner fulltext (pdf) av Prognostic value of early sustained ventricular arrhythmias in ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention: A substudy of VALIDATE-SWEDEHEART trial
Ingår i European Journal of Heart Failure, s. 2107-2129, 2023
- DOI för Interaction of heart failure and stroke: A clinical consensus statement of the ESC Council on Stroke, the Heart Failure Association (HFA) and the ESC Working Group on Thrombosis
- Ladda ner fulltext (pdf) av Interaction of heart failure and stroke: A clinical consensus statement of the ESC Council on Stroke, the Heart Failure Association (HFA) and the ESC Working Group on Thrombosis
Ingår i Scientific Reports, 2023
- DOI för Management and outcome trends in type 2 myocardial infarction: an investigation from the SWEDEHEART registry
- Ladda ner fulltext (pdf) av Management and outcome trends in type 2 myocardial infarction: an investigation from the SWEDEHEART registry