Klinisk farmakogenomik och osteoporos
![En kvinna tittar in i ett farmakogenomiskt forskningsinstrument när en man pippeterar.](/images/200.7630b4f918f153429f713679/1714320327238/Mia%20Wadelius_MG_7135-Fo%CC%88rba%CC%88ttrad-NR_1932x828.jpg)
Varför reagerar olika människor så olika på samma läkemedel? Och varför är förekomsten av benskörhetsfrakturer i Sverige och Norge högst i världen? Detta är två frågor som vi i vår forskargrupp försöker besvara.
Beskrivning av vår forskning
I Sverige drabbas cirka 14 000 personer per år av höftfraktur, den allvarligaste konsekvensen av osteoporos. Målsättningen med vår osteoporosforskning är att identifiera och studera faktorer som kan förklara den höga förekomsten av benskörhetsfrakturer och att utveckla nya behandlingsprinciper för denna sjukdom.
En annan del av forskargruppen fokuserar på läkemedelsbiverkningar. Att hitta rätt läkemedel och optimal dos innebär en balans för att maximera den positiva effekten och minimera de negativa konsekvenserna av behandlingen – biverkningarna. Ibland spelar ärftliga faktorer en avgörande roll för varför enstaka personer drabbas av allvarliga biverkningar. Målet med forskningen är att anpassa behandlingen till patienten genom precisionsmedicin.
Publikationer
Identification of risk factors for adverse drug reactions in a pharmacovigilance database
Ingår i Pharmacoepidemiology and Drug Safety, 2024
No link between type I interferon autoantibody positivity and adverse reactions to COVID-19 vaccines
Ingår i NPJ VACCINES, 2024
- DOI för No link between type I interferon autoantibody positivity and adverse reactions to COVID-19 vaccines
- Ladda ner fulltext (pdf) av No link between type I interferon autoantibody positivity and adverse reactions to COVID-19 vaccines
Genomic Analysis of Adverse Drug Reactions
2024
Whole genome case-control study of central nervous system toxicity due to antimicrobial drugs
Ingår i PLOS ONE, 2024
- DOI för Whole genome case-control study of central nervous system toxicity due to antimicrobial drugs
- Ladda ner fulltext (pdf) av Whole genome case-control study of central nervous system toxicity due to antimicrobial drugs
Identification of risk factors for adverse drug reactions in a pharmacovigilance database
Ingår i Pharmacoepidemiology and Drug Safety, s. 1431-1438, 2023
- DOI för Identification of risk factors for adverse drug reactions in a pharmacovigilance database
- Ladda ner fulltext (pdf) av Identification of risk factors for adverse drug reactions in a pharmacovigilance database
Ingår i British Journal of Clinical Pharmacology, s. 1575-1587, 2023
- DOI för Risk factors for and preventability of drug‐related hospital revisits in older patients: A post‐hoc analysis of a randomized clinical trial
- Ladda ner fulltext (pdf) av Risk factors for and preventability of drug‐related hospital revisits in older patients: A post‐hoc analysis of a randomized clinical trial
Vitamin D and bone metabolism in Graves’ disease: a prospective study
Ingår i Journal of Endocrinological Investigation, s. 425-433, 2023
- DOI för Vitamin D and bone metabolism in Graves’ disease: a prospective study
- Ladda ner fulltext (pdf) av Vitamin D and bone metabolism in Graves’ disease: a prospective study
Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy
Ingår i Nature Communications, 2023
- DOI för Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy
- Ladda ner fulltext (pdf) av Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy
Ingår i Journal of Internal Medicine, s. 616-627, 2023
- DOI för Elevated low-density lipoprotein cholesterol: An inverse marker of morbidity and mortality in patients with myocardial infarction
- Ladda ner fulltext (pdf) av Elevated low-density lipoprotein cholesterol: An inverse marker of morbidity and mortality in patients with myocardial infarction
Ingår i Frontiers in Genetics, 2022
- DOI för Genetic determinants of apixaban plasma levels and their relationship to bleeding and thromboembolic events
- Ladda ner fulltext (pdf) av Genetic determinants of apixaban plasma levels and their relationship to bleeding and thromboembolic events
Ingår i British Journal of Clinical Pharmacology, s. 4985-4996, 2022
Ingår i Journal of Bone and Joint Surgery, s. 610-620, 2022
- DOI för Risk of Revision After Arthroplasty Associated withSpecific Gene Loci: A Genomewide Association Study of Single-Nucleotide Polymorphisms in 1,130 TwinsTreated with Arthroplasty
- Ladda ner fulltext (pdf) av Risk of Revision After Arthroplasty Associated withSpecific Gene Loci: A Genomewide Association Study of Single-Nucleotide Polymorphisms in 1,130 TwinsTreated with Arthroplasty
Ingår i Pharmacogenomics (London), s. 813-820, 2022
- DOI för Genome-wide association study of liver enzyme elevation in an extended cohort of rheumatoid arthritis patients starting low-dose methotrexate
- Ladda ner fulltext (pdf) av Genome-wide association study of liver enzyme elevation in an extended cohort of rheumatoid arthritis patients starting low-dose methotrexate
Ingår i Clinical Pharmacology and Therapeutics, s. 1007-1021, 2022
Implementing precision medicine in a regionally organized healthcare system in Sweden.
Ingår i Nature Medicine, s. 1980-1982, 2022
Mast cell chymase has a negative impact on human osteoblasts
Ingår i Matrix Biology, s. 1-19, 2022
- DOI för Mast cell chymase has a negative impact on human osteoblasts
- Ladda ner fulltext (pdf) av Mast cell chymase has a negative impact on human osteoblasts
Ingår i Frontiers in Genetics, 2022
- DOI för Molecular Genetic Screening in Patients With ACE Inhibitor/Angiotensin Receptor Blocker-Induced Angioedema to Explore the Role of Hereditary Angioedema Genes
- Ladda ner fulltext (pdf) av Molecular Genetic Screening in Patients With ACE Inhibitor/Angiotensin Receptor Blocker-Induced Angioedema to Explore the Role of Hereditary Angioedema Genes
Ingår i Tietz Textbook of Laboratory Medicine, 7th Edition, Elsevier, 2022
Ingår i BMC Medicine, 2022
- DOI för The impact and causal directions for the associations between diagnosis of ADHD, socioeconomic status, and intelligence by use of a bi-directional two-sample Mendelian randomization design
- Ladda ner fulltext (pdf) av The impact and causal directions for the associations between diagnosis of ADHD, socioeconomic status, and intelligence by use of a bi-directional two-sample Mendelian randomization design
Ingår i Respiratory Medicine, 2022
- DOI för Changes in critical inhaler technique errors in inhaled COPD treatment: A one-year follow-up study in Sweden
- Ladda ner fulltext (pdf) av Changes in critical inhaler technique errors in inhaled COPD treatment: A one-year follow-up study in Sweden
HLA variants associated with azathioprine-induced pancreatitis in patients with Crohn's disease
Ingår i Clinical and Translational Science, s. 1249-1256, 2022
- DOI för HLA variants associated with azathioprine-induced pancreatitis in patients with Crohn's disease
- Ladda ner fulltext (pdf) av HLA variants associated with azathioprine-induced pancreatitis in patients with Crohn's disease
Melphalan flufenamide inhibits osteoclastogenesis by suppressing proliferation of monocytes
Ingår i Bone Reports, 2021
Ingår i Läkartidningen, 2021
Technological readiness and implementation of genomic-driven precision medicine for complex diseases
Ingår i Journal of Internal Medicine, s. 602-620, 2021
- DOI för Technological readiness and implementation of genomic-driven precision medicine for complex diseases
- Ladda ner fulltext (pdf) av Technological readiness and implementation of genomic-driven precision medicine for complex diseases
Ingår i Journal of the American College of Cardiology, s. 696-709, 2021
Ingår i Pharmacogenomics (London), s. 973-982, 2021
- DOI för Genome-wide association study of liver enzyme elevation in rheumatoid arthritis patients starting methotrexate
- Ladda ner fulltext (pdf) av Genome-wide association study of liver enzyme elevation in rheumatoid arthritis patients starting methotrexate
Ingår i JAMA Network Open, 2021
- DOI för Effects of Hospital-Based Comprehensive Medication Reviews Including Postdischarge Follow-up on Older Patients' Use of Health Care: A Cluster Randomized Clinical Trial
- Ladda ner fulltext (pdf) av Effects of Hospital-Based Comprehensive Medication Reviews Including Postdischarge Follow-up on Older Patients' Use of Health Care: A Cluster Randomized Clinical Trial
Ingår i Journal of the American Heart Association, 2021
- DOI för Factor V Leiden Does Not Modify the Phenotype of Acute Coronary Syndrome or the Extent of Myocardial Necrosis
- Ladda ner fulltext (pdf) av Factor V Leiden Does Not Modify the Phenotype of Acute Coronary Syndrome or the Extent of Myocardial Necrosis
2021
Ingår i Journal of Clinical Endocrinology and Metabolism, s. 2840-2854, 2021
- DOI för Type 2 Diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Swedish Men and Women Older Than 55 Years
- Ladda ner fulltext (pdf) av Type 2 Diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Swedish Men and Women Older Than 55 Years
Ingår i International Journal of Epidemiology, s. 234-244, 2021
- DOI för Is the Effect of Mediterranean Diet on Hip Fracture Mediated Through Type 2 Diabetes and Body Mass Index?
- Ladda ner fulltext (pdf) av Is the Effect of Mediterranean Diet on Hip Fracture Mediated Through Type 2 Diabetes and Body Mass Index?
Fasting glucose, bone area and bone mineral density: a Mendelian randomisation study
Ingår i Diabetologia, s. 1348-1357, 2021
- DOI för Fasting glucose, bone area and bone mineral density: a Mendelian randomisation study
- Ladda ner fulltext (pdf) av Fasting glucose, bone area and bone mineral density: a Mendelian randomisation study
Ingår i Clinical Pharmacology and Therapeutics, s. 1125-1135, 2021
- DOI för Genetic Risk Factors in Drug-Induced Liver Injury Due to Isoniazid-Containing Antituberculosis Drug Regimens
- Ladda ner fulltext (pdf) av Genetic Risk Factors in Drug-Induced Liver Injury Due to Isoniazid-Containing Antituberculosis Drug Regimens
Pharmacogenetics of angiotensin-converting enzyme inhibitor-induced angioedema
Ingår i Pharmacogenomics (London), s. 319-321, 2021
Ingår i European Heart Journal, s. 243-252, 2021
- DOI för Low-density lipoprotein cholesterol reduction and statin intensity in myocardial infarction patients and major adverse outcomes: a Swedish nationwide cohort study
- Ladda ner fulltext (pdf) av Low-density lipoprotein cholesterol reduction and statin intensity in myocardial infarction patients and major adverse outcomes: a Swedish nationwide cohort study
Ingår i Läkartidningen, 2021
Ingår i npj Primary Care Respiratory Medicine, 2021
- DOI för Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations
- Ladda ner fulltext (pdf) av Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations
Ingår i Frontiers in Genetics, 2020
- DOI för High-Throughput Sequencing to Investigate Associations Between HLA Genes and Metamizole-Induced Agranulocytosis
- Ladda ner fulltext (pdf) av High-Throughput Sequencing to Investigate Associations Between HLA Genes and Metamizole-Induced Agranulocytosis
Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations
Ingår i Genes, 2020
- DOI för Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations
- Ladda ner fulltext (pdf) av Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations
Ingår i The Pharmacogenomics Journal, s. 579-585, 2020
- DOI för SWEDEGENE: a Swedish nation-wide DNA sample collection for pharmacogenomic studies of serious adverse drug reactions
- Ladda ner fulltext (pdf) av SWEDEGENE: a Swedish nation-wide DNA sample collection for pharmacogenomic studies of serious adverse drug reactions
Ingår i Pharmacogenomics (London), s. 337-346, 2020
Ingår i Journal of Clinical Pharmacy and Therapeutics, s. 1021-1029, 2020
- DOI för Intervention fidelity and process outcomes of medication reviews including post-discharge follow-up in older hospitalized patients: Process evaluation of the MedBridge trial.
- Ladda ner fulltext (pdf) av Intervention fidelity and process outcomes of medication reviews including post-discharge follow-up in older hospitalized patients: Process evaluation of the MedBridge trial.
Ingår i Journal of Evaluation In Clinical Practice, s. 149-157, 2020
Ingår i European Journal of Clinical Pharmacology, s. 775-784, 2020
- DOI för Facilitators and barriers for performing comprehensive medication reviews and follow-up by multiprofessional teams in older hospitalised patients
- Ladda ner fulltext (pdf) av Facilitators and barriers for performing comprehensive medication reviews and follow-up by multiprofessional teams in older hospitalised patients
Ingår i Clinical Pharmacology and Therapeutics, s. 1195-1202, 2020
- DOI för Exome sequencing reveals common and rare variants in F5 associated with ACE inhibitor and angiotensin receptor blocker-induced angioedema
- Ladda ner fulltext (pdf) av Exome sequencing reveals common and rare variants in F5 associated with ACE inhibitor and angiotensin receptor blocker-induced angioedema
Ingår i PLoS Medicine, 2020
- DOI för Combined associations of body mass index and adherence to a Mediterranean-like diet with all-cause and cardiovascular mortality: A cohort study
- Ladda ner fulltext (pdf) av Combined associations of body mass index and adherence to a Mediterranean-like diet with all-cause and cardiovascular mortality: A cohort study
Ingår i Cardiovascular Drugs and Therapy, s. 549-559, 2020
Ingår i The Pharmacogenomics Journal, s. 770-783, 2020
- DOI för Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment.
- Ladda ner fulltext (pdf) av Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment.
Daytime melatonin levels in saliva are associated with inflammatory markers and anxiety disorders
Ingår i Psychoneuroendocrinology, 2020
- DOI för Daytime melatonin levels in saliva are associated with inflammatory markers and anxiety disorders
- Ladda ner fulltext (pdf) av Daytime melatonin levels in saliva are associated with inflammatory markers and anxiety disorders
Ingår i The Pharmacogenomics Journal, s. 306-319, 2020
Våra forskningsinriktningar
Klinisk farmakogenomik
Vi försöker hitta svaren på varför olika människor reagerar så olika på samma läkemedel.
![](/images/200.64989fef18fa42499d625c0/1716476152217/Klin%20farm_105112_JZ9_1820_1200x800.jpg)
Osteoporos
Vi försöker hitta svaren på varför förekomsten av benskörhetsfrakturer i Sverige och Norge är högst i världen.
![](/images/200.64989fef18fa42499d625d2/1716476303120/Osteoporos_U4A9927_1200x800.jpg)