Neurologi
![Gruppbild på medlemmarna i forskargruppen för neurologi.](/images/200.7630b4f918f153429f71219/1714063980507/Gruppbild_221216_1932x828.jpg)
Forskningsaktiviteten på enheten för neurologi är starkt patientorienterad. I den kliniska verksamheten väcks dagligen vetenskapliga frågor vilka vi försöker lösa med stöd av resultat från bl.a. interventions-, observations- och epidemiologiska studier samt translationella studier där material från biobank används.
Beskrivning av vår forskning
Våra forskningsområden inkluderar vanliga neurologiska sjukdomar som epilepsi, motorikstörningar, akut stroke och multipel skleros, men också sömnsjukdomar, som narkolepsi, och ännu mer ovanliga tillstånd som neurogenetiska sjukdomar, till exempel Huntingtons sjukdom och låggradiga gliom. Områden som störningar i autonoma nervsystemet och utveckling av behandlingar har varit framträdande sedan länge.
Ett gemensamt fokus kan innefattas i begreppet ”Neuroterapi”, där vår enhet sedan länge befäst en stark ställning för att utveckla behandling vid sjukdom. Sådana exempel är läkemedelsbehandling med pump vid svår Parkinsons sjukdom, epilepsikirurgi och stamcellstransplantation mot MS, vidare avancerad bilddiagnostik vid kartläggning av hjärntumörer, samt shuntoperation vid normaltryckshydrocefalus (NPH).
Forskningsprojekt
- Huntingtons sjukdom och andra neurogenetiska sjukdomar
- ALS och andra motorneuronsjukdomar
- Epilepsi
- MS och andra neuroinflammatoriska sjukdomar
- Normaltryckshydrocefalus och andra likvorcirkulationsstörinngar
- Parkinsons sjukdom och andra rörelsestörningar
- Stroke och andra cerebrovaskulära sjukdomar
Publikationer
Ingår i iScience, 2024
- DOI för Cerebrospinal fluid and plasma concentrations of the inflammatory marker soluble CD27 in a large surgical population
- Ladda ner fulltext (pdf) av Cerebrospinal fluid and plasma concentrations of the inflammatory marker soluble CD27 in a large surgical population
Ingår i Journal of the Neurological Sciences, 2024
- DOI för Cerebrospinal fluid glial fibrillary acidic protein, in contrast to amyloid beta protein, is associated with disease symptoms in Huntington's disease
- Ladda ner fulltext (pdf) av Cerebrospinal fluid glial fibrillary acidic protein, in contrast to amyloid beta protein, is associated with disease symptoms in Huntington's disease
Ingår i Multiple Sclerosis and Related Disorders, 2024
- DOI för Cerebrospinal fluid mtDNA concentrations are increased in multiple sclerosis and were normalized after intervention with autologous hematopoietic stem cell transplantation
- Ladda ner fulltext (pdf) av Cerebrospinal fluid mtDNA concentrations are increased in multiple sclerosis and were normalized after intervention with autologous hematopoietic stem cell transplantation
Characterization of the Increase in Narcolepsy following the 2009 H1N1 Pandemic in Sweden
Ingår i Journal of Clinical Medicine, 2024
- DOI för Characterization of the Increase in Narcolepsy following the 2009 H1N1 Pandemic in Sweden
- Ladda ner fulltext (pdf) av Characterization of the Increase in Narcolepsy following the 2009 H1N1 Pandemic in Sweden
Ingår i Physica medica (Testo stampato), 2024
- DOI för Comparison of quantitative [11C]PE2I brain PET studies between an integrated PET/MR and a stand-alone PET system
- Ladda ner fulltext (pdf) av Comparison of quantitative [11C]PE2I brain PET studies between an integrated PET/MR and a stand-alone PET system
Evaluation of [11C]UCB-A positron emission tomography in human brains
Ingår i EJNMMI Research, 2024
- DOI för Evaluation of [11C]UCB-A positron emission tomography in human brains
- Ladda ner fulltext (pdf) av Evaluation of [11C]UCB-A positron emission tomography in human brains
Evoked potentials after autologous hematopoietic stem cell transplantation for multiple sclerosis
Ingår i Multiple Sclerosis and Related Disorders, 2024
- DOI för Evoked potentials after autologous hematopoietic stem cell transplantation for multiple sclerosis
- Ladda ner fulltext (pdf) av Evoked potentials after autologous hematopoietic stem cell transplantation for multiple sclerosis
Ingår i International Journal of Laboratory Hematology, s. 42-49, 2024
- DOI för Extracellular vesicles in plasma and cerebrospinal fluid in patients with COVID-19 and neurological symptoms
- Ladda ner fulltext (pdf) av Extracellular vesicles in plasma and cerebrospinal fluid in patients with COVID-19 and neurological symptoms
Ingår i BMJ Open, 2024
- DOI för Factors associated with changes in walking performance in individuals 3 months after stroke or TIA: secondary analyses from a randomised controlled trial of SMS-delivered training instructions in Sweden
- Ladda ner fulltext (pdf) av Factors associated with changes in walking performance in individuals 3 months after stroke or TIA: secondary analyses from a randomised controlled trial of SMS-delivered training instructions in Sweden
Habitual short sleepers with pre-existing medical conditions are at higher risk of Long COVID
Ingår i Journal of Clinical Sleep Medicine (JCSM), s. 111-119, 2024
Ingår i Journal of Neurology, Neurosurgery and Psychiatry, s. 125-133, 2024
- DOI för Haematopoietic stem cell transplantation for treatment of relapsing-remitting multiple sclerosis in Sweden: an observational cohort study
- Ladda ner fulltext (pdf) av Haematopoietic stem cell transplantation for treatment of relapsing-remitting multiple sclerosis in Sweden: an observational cohort study
Ingår i BMC Neurology, 2024
- DOI för Large variations in atrial fibrillation screening practice after ischemic stroke and transient ischemic attack in Sweden: a survey study
- Ladda ner fulltext (pdf) av Large variations in atrial fibrillation screening practice after ischemic stroke and transient ischemic attack in Sweden: a survey study
Reduced long-term mortality after successful resective epilepsy surgery: a population-based study
Ingår i Journal of Neurology, Neurosurgery and Psychiatry, s. 249-255, 2024
- DOI för Reduced long-term mortality after successful resective epilepsy surgery: a population-based study
- Ladda ner fulltext (pdf) av Reduced long-term mortality after successful resective epilepsy surgery: a population-based study
Ingår i Journal of Neurosurgery, s. 1493-1500, 2024
- DOI för Volumetric effect of shunt adjustments in normal pressure hydrocephalus: a randomized, double-blind trial
- Ladda ner fulltext (pdf) av Volumetric effect of shunt adjustments in normal pressure hydrocephalus: a randomized, double-blind trial
A comprehensive diagnostic approach in suspected neurosarcoidosis
Ingår i Scientific Reports, 2023
- DOI för A comprehensive diagnostic approach in suspected neurosarcoidosis
- Ladda ner fulltext (pdf) av A comprehensive diagnostic approach in suspected neurosarcoidosis
Absence of Oligoclonal Bands in Multiple Sclerosis: A Call for Differential Diagnosis
Ingår i Journal of Clinical Medicine, 2023
- DOI för Absence of Oligoclonal Bands in Multiple Sclerosis: A Call for Differential Diagnosis
- Ladda ner fulltext (pdf) av Absence of Oligoclonal Bands in Multiple Sclerosis: A Call for Differential Diagnosis
Ingår i PLOS ONE, 2023
- DOI för Anti-Müllerian hormone and pregnancy after autologous hematopoietic stem cell transplantation for multiple sclerosis
- Ladda ner fulltext (pdf) av Anti-Müllerian hormone and pregnancy after autologous hematopoietic stem cell transplantation for multiple sclerosis
Ingår i Fluids and Barriers of the CNS, 2023
- DOI för Association between ventricular CSF biomarkers and outcome after shunt surgery in idiopathic normal pressure hydrocephalus
- Ladda ner fulltext (pdf) av Association between ventricular CSF biomarkers and outcome after shunt surgery in idiopathic normal pressure hydrocephalus
Ingår i BMC Public Health, 2023
- DOI för Associations between changes in habitual sleep duration and lower self-rated health among COVID-19 survivors: findings from a survey across 16 countries/regions
- Ladda ner fulltext (pdf) av Associations between changes in habitual sleep duration and lower self-rated health among COVID-19 survivors: findings from a survey across 16 countries/regions
Ingår i Frontiers in Genetics, 2023
- DOI för Case report: a novel deep intronic splice-altering variant in DMD as a cause of Becker muscular dystrophy
- Ladda ner fulltext (pdf) av Case report: a novel deep intronic splice-altering variant in DMD as a cause of Becker muscular dystrophy
Ingår i Brain Communications, 2023
- DOI för Cerebrospinal fluid cytokines after autologous haematopoietic stem cell transplantation and intrathecal rituximab treatment for multiple sclerosis
- Ladda ner fulltext (pdf) av Cerebrospinal fluid cytokines after autologous haematopoietic stem cell transplantation and intrathecal rituximab treatment for multiple sclerosis
Ingår i European Journal of Neurology, s. 3256-3264, 2023
- DOI för Clinically relevant increases in serum neurofilament light chain and glial fibrillary acidic protein in patients with Susac syndrome
- Ladda ner fulltext (pdf) av Clinically relevant increases in serum neurofilament light chain and glial fibrillary acidic protein in patients with Susac syndrome
Ingår i Neurology, 2023
- DOI för Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Drug-Resistant Epilepsy in the MORE Multicenter Patient Registry
- Ladda ner fulltext (pdf) av Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Drug-Resistant Epilepsy in the MORE Multicenter Patient Registry
Ingår i Journal of Rehabilitation Medicine, 2023
- DOI för Development of a Swedish short version of the Montreal Cognitive Assessment for cognitive screening in patients with stroke
- Ladda ner fulltext (pdf) av Development of a Swedish short version of the Montreal Cognitive Assessment for cognitive screening in patients with stroke
Early-onset hereditary isolated non-neurogenic orthostatic hypotension in a Swedish family
Ingår i Clinical Autonomic Research, s. 421-432, 2023
- DOI för Early-onset hereditary isolated non-neurogenic orthostatic hypotension in a Swedish family
- Ladda ner fulltext (pdf) av Early-onset hereditary isolated non-neurogenic orthostatic hypotension in a Swedish family
Experiences in implementing immunopsychiatry in real life
Ingår i Journal of Affective Disorders Reports, 2023
- DOI för Experiences in implementing immunopsychiatry in real life
- Ladda ner fulltext (pdf) av Experiences in implementing immunopsychiatry in real life
Ingår i Journal of the Neurological Sciences, 2023
- DOI för Genetic screening for Huntington disease phenocopies in Sweden: A tertiary center case series focused on short tandem repeat (STR) disorders
- Ladda ner fulltext (pdf) av Genetic screening for Huntington disease phenocopies in Sweden: A tertiary center case series focused on short tandem repeat (STR) disorders
Hematopoietic Stem Cell Transplantation for Treatment of Multiple Sclerosis in Sweden
2023
Image-derived input functions from dynamic O-15-water PET scans using penalised reconstruction
Ingår i EJNMMI Physics, 2023
- DOI för Image-derived input functions from dynamic O-15-water PET scans using penalised reconstruction
- Ladda ner fulltext (pdf) av Image-derived input functions from dynamic O-15-water PET scans using penalised reconstruction
Immune response in blood before and after epileptic and psychogenic non-epileptic seizures
Ingår i Heliyon, 2023
- DOI för Immune response in blood before and after epileptic and psychogenic non-epileptic seizures
- Ladda ner fulltext (pdf) av Immune response in blood before and after epileptic and psychogenic non-epileptic seizures
Ingår i PLOS ONE, 2023
- DOI för Inventory study of an early pandemic COVID-19 cohort in South-Eastern Sweden, focusing on neurological manifestations
- Ladda ner fulltext (pdf) av Inventory study of an early pandemic COVID-19 cohort in South-Eastern Sweden, focusing on neurological manifestations
Ingår i Fluids and Barriers of the CNS, 2023
- DOI för Levels of inflammatory cytokines MCP-1, CCL4, and PD-L1 in CSF differentiate idiopathic normal pressure hydrocephalus from neurodegenerative diseases
- Ladda ner fulltext (pdf) av Levels of inflammatory cytokines MCP-1, CCL4, and PD-L1 in CSF differentiate idiopathic normal pressure hydrocephalus from neurodegenerative diseases
Ingår i Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, s. 727-735, 2023
- DOI för Living with a parent with ALS: adolescents' need for professional support from the adolescents' and the parents' perspectives
- Ladda ner fulltext (pdf) av Living with a parent with ALS: adolescents' need for professional support from the adolescents' and the parents' perspectives
Ingår i BMC Geriatrics, 2023
- DOI för Longitudinal neuropsychological trajectories in idiopathic normal pressure hydrocephalus: a population-based study
- Ladda ner fulltext (pdf) av Longitudinal neuropsychological trajectories in idiopathic normal pressure hydrocephalus: a population-based study
Long-term follow up of patients with WHO grade 2 oligodendroglioma.
Ingår i Journal of Neuro-Oncology, s. 65-74, 2023
Meningioma classification by immunohistochemistry: A replicability study
Ingår i BRAIN AND SPINE, 2023
- DOI för Meningioma classification by immunohistochemistry: A replicability study
- Ladda ner fulltext (pdf) av Meningioma classification by immunohistochemistry: A replicability study
Ingår i Nutrition and Cancer, s. 112-122, 2023
- DOI för Methodological Approaches to Ketogenic Dietary Treatments in Glioma Patients from a Nutritional Point of View
- Ladda ner fulltext (pdf) av Methodological Approaches to Ketogenic Dietary Treatments in Glioma Patients from a Nutritional Point of View
Ingår i BMJ Open, 2023
- DOI för Multicentre, national, investigator-initiated, randomised, parallel-group, register-based superiority trial to compare extended ECG monitoring versus standard ECG monitoring in elderly patients with ischaemic stroke or transient ischaemic attack and the effect on stroke, death and intracerebral bleeding: the AF SPICE protocol
- Ladda ner fulltext (pdf) av Multicentre, national, investigator-initiated, randomised, parallel-group, register-based superiority trial to compare extended ECG monitoring versus standard ECG monitoring in elderly patients with ischaemic stroke or transient ischaemic attack and the effect on stroke, death and intracerebral bleeding: the AF SPICE protocol
Ingår i European Journal of Neurology, s. 3142-3148, 2023
- DOI för Myoclonus in patients with COVID-19: Findings of autoantibodies against brain structures in cerebrospinal fluid
- Ladda ner fulltext (pdf) av Myoclonus in patients with COVID-19: Findings of autoantibodies against brain structures in cerebrospinal fluid
Ingår i Palliative & Supportive Care, 2023
- DOI för Pain in patients with motor neuron disease: Variation of pain and association with disease severity, health-related quality of life and depression – A longitudinal study
- Ladda ner fulltext (pdf) av Pain in patients with motor neuron disease: Variation of pain and association with disease severity, health-related quality of life and depression – A longitudinal study
Ingår i BMC Medical Ethics, 2023
- DOI för Patients accept therapy using embryonic stem cells for Parkinson's disease: a discrete choice experiment
- Ladda ner fulltext (pdf) av Patients accept therapy using embryonic stem cells for Parkinson's disease: a discrete choice experiment
Ingår i Translational Psychiatry, s. 32, 2023
- DOI för Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals.
- Ladda ner fulltext (pdf) av Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals.
Phosphorylated α-synuclein in skin Schwann cells: a new biomarker for multiple system atrophy
Ingår i Brain, s. 1065-1074, 2023
Physical Activity Trajectories and Functional Recovery After Acute Stroke Among Adults in Sweden
Ingår i JAMA Network Open, 2023
- DOI för Physical Activity Trajectories and Functional Recovery After Acute Stroke Among Adults in Sweden
- Ladda ner fulltext (pdf) av Physical Activity Trajectories and Functional Recovery After Acute Stroke Among Adults in Sweden
Plasma neurofilament light chain is elevated after transcatheter aortic valve implantation
Ingår i Cardiology, s. 478-483, 2023
- DOI för Plasma neurofilament light chain is elevated after transcatheter aortic valve implantation
- Ladda ner fulltext (pdf) av Plasma neurofilament light chain is elevated after transcatheter aortic valve implantation
Ingår i International Journal of Stroke, s. 543-554, 2023
- DOI för Predictors of post-stroke cognitive impairment using acute structural MRI neuroimaging: A systematic review and meta-analysis
- Ladda ner fulltext (pdf) av Predictors of post-stroke cognitive impairment using acute structural MRI neuroimaging: A systematic review and meta-analysis
Ingår i Journal of Neurology, s. 3315-3328, 2023
Ingår i Lancet Neurology, s. 117-126, 2023
Ingår i Chronobiology International, s. 114-122, 2023
Ingår i Journal of Sleep Research, 2023
- DOI för Sleep symptoms are essential features of long-COVID - Comparing healthy controls with COVID-19 cases of different severity in the international COVID sleep study (ICOSS-II)
- Ladda ner fulltext (pdf) av Sleep symptoms are essential features of long-COVID - Comparing healthy controls with COVID-19 cases of different severity in the international COVID sleep study (ICOSS-II)